| Insiders | Shares | % | Avg Price | Total $ | |
|---|---|---|---|---|---|
| Buys | 2 | +3,633,980 | 80% | $67.18 | +$244,139,200 |
| Sells | 8 | -890,353 | 20% | $78.25 | -$69,673,554 |
| Net | -6 | +2,743,627 | 61% | +$174,465,646 |
| Name | Relationship | Holdings Value | Past Year Net Change | Change % | Report Date |
|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | Director, 10%+ Owner | $1,134,150,081 | +$230,183,852 | +25% | 11 Dec 2025 |
| Atlas Venture Fund X, L.P. | 10%+ Owner | $235,830,130 | 11 Mar 2024 | ||
| ATLAS VENTURE ASSOCIATES X, L.P. | 10%+ Owner | $173,161,222 | 11 Aug 2021 | ||
| Nello Mainolfi | Chief Executive Officer, Director | $62,282,570 | -$18,736,489 | -23% | 02 Mar 2026 |
| Bruce Booth | Director | $60,868,484 | -$29,077,626 | -32% | 02 Mar 2026 |
| Bruce N. Jacobs | Chief Financial Officer | $20,147,865 | -$5,052,611 | -20% | 02 Mar 2026 |
| BVF PARTNERS L P/IL | Director, Other* | $18,823,193 | +$13,955,348 | +287% | 25 Jun 2025 |
| Jared Gollob | Chief Medical Officer | $10,146,697 | -$9,134,595 | -47% | 02 Mar 2026 |
| Jeremy G. Chadwick | Chief Operating Officer | $5,697,279 | -$2,736,703 | -32% | 11 Mar 2026 |
| Noah Goodman | Chief Business Officer | $4,982,926 | 02 Mar 2026 | ||
| Brian Adams | Chief Legal Officer | $4,757,632 | 02 Mar 2026 | ||
| Ellen Chiniara | Chief Legal Officer | $2,483,003 | 03 Mar 2025 | ||
| Elaine Caughey | Chief Business Officer | $570,472 | 01 Mar 2023 | ||
| Elena Ridloff | Director | $0 | -$778,200 | -100% | 25 Jun 2025 |
| Jeffrey W. Albers | Director | $0 | -$1,055,873 | -100% | 08 Dec 2025 |
| Pamela Esposito | Director | $0 | -$3,101,457 | -100% | 20 Feb 2026 |
| Dr. Joanna Horobin | Director | $0 | 07 Jun 2024 | ||
| JOHN MARAGANORE | Director | 25 Jun 2025 | |||
| Gorjan Hrustanovic | Director | 25 Jun 2025 | |||
| Leigh Morgan | Director | 18 Jun 2024 | |||
| Richard Chesworth | Chief Scientific Officer | 27 Aug 2021 | |||
| Victor Sandor | Director | 25 Jun 2025 | |||
| Steven Edward Hall | Director | 16 Jun 2021 | |||
| Donald William Nicholson | Director | 15 Jun 2022 |
| Insider | Symbol | Class | Transaction | % | Value $ | * Price $ | Shares | Shares Owned | Date | Ownership |
|---|