Third Rock Ventures V, L.P. - Insider Trading & Ownership

Location: 29 Newbury Street, 3 Rd Floor, Boston, MA
Summary: The estimated value of insider holdings of Third Rock Ventures V, L.P. is at least $189M dollars as of October 28, 2024. Third Rock Ventures V, L.P. is the 10%+ Owner of Rapport Therapeutics, Inc. and owns shares of Rapport Therapeutics, Inc. (RAPP) stock worth about $80.9M. Third Rock Ventures V, L.P. is the 10%+ Owner of Septerna, Inc. and owns shares of Septerna, Inc. (SEPN) stock worth about $54.8M. Third Rock Ventures V, L.P. is the 10%+ Owner of CARGO Therapeutics, Inc. and owns shares of CARGO Therapeutics, Inc. (CRGX) stock worth about $53.2M.
Signature: /s/ Kevin Gillis, Chief Operating Officer of TRV GP V, LLC, general partner of Third Rock Ventures GP V, L.P., general partner of Third Rock Ventures V, L.P.
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Ownership of Third Rock Ventures V, L.P.

Symbol	Company	Relationship	Holdings Value	Report Period
RAPP	Rapport Therapeutics, Inc.	10%+ Owner	$80.9M	Jun 10, 2024
SEPN	Septerna, Inc.	10%+ Owner	$54.8M	Oct 28, 2024
CRGX	CARGO Therapeutics, Inc.	10%+ Owner	$53.2M	Nov 14, 2023

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Insider Transactions Reported by Third Rock Ventures V, L.P.:

Sym	Company	Class	Transaction	%	Value $	* Price $	Shares	Shares After	Date	Ownership
SEPN	Septerna, Inc.	Common Stock	Purchase	+9.73%	$5.03M	18.00	+280K	3.15M	10/28/2024	See Footnotes
SEPN	Septerna, Inc.	Common Stock	Purchase	+6.34%	$6.67M	18.00	+371K	6.22M	10/28/2024	Direct
SEPN	Septerna, Inc.	Common Stock	Conversion of derivative security		$0	0.00	+2.87M	2.87M	10/28/2024	See Footnotes
SEPN	Septerna, Inc.	Common Stock	Conversion of derivative security	+454.4%	$0	0.00	+4.79M	5.85M	10/28/2024	Direct
SEPN	Septerna, Inc.	Series B Preferred Stock	Conversion of derivative security	-100%	$0	0.00	-24.7M	0	10/28/2024	See Footnotes
SEPN	Septerna, Inc.	Series A Preferred Stock	Conversion of derivative security	-100%	$0	0.00	-41.3M	0	10/28/2024	Direct
RAPP	Rapport Therapeutics, Inc.	Common Stock	Conversion of derivative security		$0	0.00	+969K	969K	6/10/2024	By Third Rock Ventures VI, L.P.
RAPP	Rapport Therapeutics, Inc.	Common Stock	Conversion of derivative security	+1122.2%	$0	0.00	+6.55M	7.14M	6/10/2024	Direct
RAPP	Rapport Therapeutics, Inc.	Series B Preferred Stock	Conversion of derivative security	-100%	$0	0.00^*	-298K	0	6/10/2024	By Third Rock Ventures VI, L.P.
RAPP	Rapport Therapeutics, Inc.	Series A Preferred Stock	Conversion of derivative security	-100%	$0	0.00^*	-8M	0	6/10/2024	By Third Rock Ventures VI, L.P.
RAPP	Rapport Therapeutics, Inc.	Series A Preferred Stock	Conversion of derivative security	-100%	$0	0.00^*	-56.1M	0	6/10/2024	Direct
CRGX	CARGO Therapeutics, Inc.	Common Stock	Purchase	+281.4%	$20M	15.00^*	+1.33M	1.81M	11/14/2023	See Footnotes
CRGX	CARGO Therapeutics, Inc.	Common Stock	Conversion of derivative security		$0		+1.74M	1.74M	11/14/2023	Direct
CRGX	CARGO Therapeutics, Inc.	Common Stock	Conversion of derivative security		$0		+474K	474K	11/14/2023	See Footnotes
CRGX	CARGO Therapeutics, Inc.	Series A-1 Preferred Stock	Conversion of derivative security	-100%	$0	0.00^*	-6.43M	0	11/14/2023	See Footnotes
CRGX	CARGO Therapeutics, Inc.	Series A-1 Preferred Stock	Conversion of derivative security	-100%	$0	0.00^*	-23.6M	0	11/14/2023	Direct

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* An asterisk sign (*) next to the price indicates that the price is likely invalid.