Nello Mainolfi - 17 Dec 2025 Form 4 Insider Report for Kymera Therapeutics, Inc. (KYMR)

Role: Chief Executive Officer, Director
Signature: /s/ Bruce Jacobs, as Attorney-in-Fact
Issuer symbol: KYMR
Transactions as of: 17 Dec 2025
Net transactions value: +$99,985
Form type: 4
Filing time: 17 Dec 2025, 18:07:57 UTC
Previous filing: 08 Dec 2025
Next filing: 31 Dec 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Mainolfi Nello	Chief Executive Officer, Director	C/O KYMERA THERAPEUTICS, INC., 500 NORTH BEACON STREET, 4TH FLOOR, WATERTOWN	/s/ Bruce Jacobs, as Attorney-in-Fact	17 Dec 2025	0001821189

Transactions Table

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Ownership	Footnotes
transaction	KYMR	Common Stock	Options Exercise	$99,985	+2,595	+0.39%	$38.53	663,077	17 Dec 2025	Direct

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	KYMR	Stock Option (Right to Buy)	Options Exercise	$0	-2,595	-0.94%	$0.000000	272,505	17 Dec 2025	Common Stock	2,595	$38.53	Direct	F1

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The shares underlying this stock option are fully vested and exercisable.