Nello Mainolfi - 08 Dec 2025 Form 4 Insider Report for Kymera Therapeutics, Inc. (KYMR)

Signature
/s/ Bruce Jacobs, as Attorney-in-Fact
Issuer symbol
KYMR
Transactions as of
08 Dec 2025
Net transactions value
-$8,709,000
Form type
4
Filing time
08 Dec 2025, 18:09:20 UTC
Previous filing
29 Oct 2025
Next filing
17 Dec 2025

Reporting Owners (1)

Name Relationship Address Signature Signature date CIK
Mainolfi Nello Chief Executive Officer, Director C/O KYMERA THERAPEUTICS, INC., 500 NORTH BEACON STREET, 4TH FLOOR, WATERTOWN /s/ Bruce Jacobs, as Attorney-in-Fact 08 Dec 2025 0001821189

Transactions Table

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Ownership Footnotes
transaction KYMR Common Stock Options Exercise $208,000 +100,000 +15% $2.08 760,482 08 Dec 2025 Direct F1
transaction KYMR Common Stock Sale $8,917,000 -100,000 -13% $89.17 660,482 08 Dec 2025 Direct F1

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type Sym Class Transaction Value $ Shares Change % * Price $ Shares After Date Underlying Class Amount Exercise Price Ownership Footnotes
transaction KYMR Stock Option (Right to Buy) Options Exercise $0 -100,000 -25% $0.000000 305,559 08 Dec 2025 Common Stock 100,000 $2.08 Direct F1, F2
* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.

Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).

Explanation of Responses:

Id Content
F1 These transactions were effected pursuant to a Rule 10b5-1 trading plan dated September 6, 2024 adopted by the reporting person.
F2 The shares underlying this stock option are fully vested and exercisable.