Insider Transactions Reported by 17 Insiders of 89bio, Inc.

Location: San Francisco, CA

Quick Takeaways

89bio, Inc. has 17 insiders with reported activity on this page.
Net insider value flow over the last year: -$206,488.
Recent transaction rows are available for direct filing-level review.

What Changed

Buy value: ; sell value: $206,487.
Net share flow: -25,790.

Why This Matters

This page gives a plain-language issuer insider context before you inspect transaction-level evidence.
Use the filing links below to verify timestamps, codes, and ownership impacts directly from SEC forms.

Official SEC Source

Filed on Form 4

Issuer insider activity is sourced from SEC Forms 3, 4, and 5.

See Original Filing

Insider trading overview

Last 12 months

Net insider flow leans to selling over the last 12 months. Net value: -$206,488.

Buys

Shares: 0

Insiders: 0

Sells

$206,488

Shares: 25,790

Insiders: 1

Net

-$206,488

Shares: -25,790

Insiders: -1

Window (months)	Sell shares	Buy $	Sell $	Net $
0-3	0	$0	$0	$0
3-6	0	$0	$0	$0
6-9	10,461	$0	$115,280	-$115,280
9-12	15,329	$0	$91,208	-$91,208

89bio, Inc. executives and other stock owners filed with the SEC include:

Name	Relationship	Holdings Value	Past Year Net Change	Change %	Valuation	Report Date
RA CAPITAL MANAGEMENT, L.P.	Director, 10%+ Owner	$36,809,857			Mixed	30 Oct 2025
ORBIMED ADVISORS LLC	10%+ Owner	$21,093,397			Mixed	25 Jan 2022
Ram Waisbourd	Chief Operating Officer and Chief Business Officer	$100,888			Mixed	17 Feb 2022
Charles McWherter	Director	$0			Mixed	30 Oct 2025
Quoc Le-Nguyen	Chief Technical Operations Officer	$0	-$206,488	-100%	Mixed	30 Oct 2025
Michael R. Hayden	Director	$0			Mixed	30 Oct 2025
Francis Willard Sarena	Chief Operating Officer	$0			Mixed	30 Oct 2025
Harry H. Mansbach	Chief Medical Officer	$0			Mixed	30 Oct 2025
Rohan Palekar	Chief Executive Officer, Director	$0			Mixed	30 Oct 2025
Ryan Martins	Chief Financial Officer	$0			Mixed	30 Oct 2025
Gregory Grunberg	Director, 10%+ Owner				Mixed	09 Feb 2023
Derek DiRocco	Director				Mixed	30 Oct 2025
Lota S. Zoth	Director				Mixed	30 Oct 2025
Martin Babler	Director				Mixed	30 Oct 2025
Kathleen Laporte	Director				Mixed	30 Oct 2025
Edward Morrow Atkinson III	Director				Mixed	30 Oct 2025
Steven M. Altschuler	Director				Mixed	30 Oct 2025

Top shareholders of 89bio, Inc. (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
SUVRETTA CAPITAL MANAGEMENT, LLC	13D/G	—	5.6%	8,280,000	$121,716,000	-$93,071,712	30 Sep 2025	13D/G
VANGUARD GROUP INC	13D/G	The Vanguard Group	5.6%	8,242,154	$80,937,952	$0	30 Jun 2025	13D/G
JANUS HENDERSON GROUP PLC	13D/G	—	3.6%	5,378,185	$79,060,933	-$226,534,240	30 Sep 2025	13D/G
RA CAPITAL MANAGEMENT, L.P.	3/4/5	Director, 10%+ Owner	—	—	$36,809,857	—	30 Oct 2025	3/4/5
BIOTECHNOLOGY VALUE FUND L P	13D/G	BVF PARTNERS L P/IL	3.6%	4,333,885	$29,903,806	$0	31 Dec 2024	13D/G
ORBIMED ADVISORS LLC	3/4/5	10%+ Owner	— class O/S missing	1,829,436	$21,093,397	—	25 Jan 2022	3/4/5
RTW INVESTMENTS, LP	13D/G	—	1.3%	1,967,527	$13,575,936	$0	31 Mar 2025	13D/G
Deutsche Girozentrale DekaBank	13F	Individual	0.06%	90,000	$1,107,000	—	31 Dec 2025	13F
Ram Waisbourd	3/4/5	Chief Operating Officer and Chief Business Officer	— mixed-class rows	33,750 mixed-class rows	$100,888	—	17 Feb 2022	3/4/5
IFP Advisors, Inc	13F	Company	0%	17	$252	—	31 Dec 2025	13F
Gregory Grunberg	3/4/5	Director, 10%+ Owner	— class O/S missing	27,400	—	—	09 Feb 2023	3/4/5

Recent Insider Transactions by Companies or Individuals for 89bio, Inc.

Showing up to 300 most recent insider transactions from the last 12 months.

Insider	Symbol	Class	Transaction	%	Value $	* Price $	Shares	Shares Owned	Date	Ownership
Ra Capital Management, L.P.	ETNB	Common Stock	Disposed to Issuer	-100%			-19,889,683	0	30 Oct 2025	See Footnotes
Ra Capital Management, L.P.	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-180,450	0	30 Oct 2025	See footnotes
Ra Capital Management, L.P.	ETNB	Pre-Funded Warrants (Right to Buy)	Disposed to Issuer	-100%			-4,331,081	0	30 Oct 2025	See footnotes
Kathleen LaPorte	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-166,450	0	30 Oct 2025	Direct
Michael R. Hayden	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-165,516	0	30 Oct 2025	See footnote
Michael R. Hayden	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-80,904	0	30 Oct 2025	Direct
Michael R. Hayden	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-233,760	0	30 Oct 2025	Direct
Ryan Martins	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-374,295	0	30 Oct 2025	Direct
Ryan Martins	ETNB	Common Stock	Award	10.3%			35,000	374,295	30 Oct 2025	Direct
Ryan Martins	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-738,102	0	30 Oct 2025	Direct
Steven M. Altschuler	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-213,450	0	30 Oct 2025	Direct
Rohan Palekar	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-934,273	0	30 Oct 2025	Direct
Rohan Palekar	ETNB	Common Stock	Award	15.4%			125,000	934,273	30 Oct 2025	Direct
Rohan Palekar	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-2,599,223	0	30 Oct 2025	Direct
Charles McWherter	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-25,000	0	30 Oct 2025	Direct
Charles McWherter	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-124,100	0	30 Oct 2025	Direct
Edward Morrow Atkinson III	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-148,950	0	30 Oct 2025	Direct
Lota S. Zoth	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-186,450	0	30 Oct 2025	Direct
Quoc Le-Nguyen	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-13,694	0	30 Oct 2025	By Spouse
Quoc Le-Nguyen	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-351,684	0	30 Oct 2025	Direct
Quoc Le-Nguyen	ETNB	Common Stock	Award	16.6%			50,000	351,684	30 Oct 2025	Direct
Quoc Le-Nguyen	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-43,900	0	30 Oct 2025	By Spouse
Quoc Le-Nguyen	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-829,875	0	30 Oct 2025	Direct
Martin Babler	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-124,100	0	30 Oct 2025	Direct
Derek DiRocco	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-19,500	0	30 Oct 2025	See footnote
Derek DiRocco	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-160,950	0	30 Oct 2025	Direct
Francis Willard Sarena	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-75,310	0	30 Oct 2025	Direct
Francis Willard Sarena	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-565,000	0	30 Oct 2025	Direct
Harry H. Mansbach	ETNB	Common Stock	Disposition pursuant to a tender of shares in a change of control transaction	-100%			-352,656	0	30 Oct 2025	Direct
Harry H. Mansbach	ETNB	Common Stock	Award	16.5%			50,000	352,656	30 Oct 2025	Direct
Harry H. Mansbach	ETNB	Stock Option (Right to Buy)	Disposed to Issuer	-100%			-954,741	0	30 Oct 2025	Direct
Ryan Martins	ETNB	Common Stock	Options Exercise	31.3%			80,799	339,295	22 Oct 2025	Direct
Ryan Martins	ETNB	Stock Option (Right to Buy)	Options Exercise	-100%			-80,799	0	22 Oct 2025	Direct
Francis Willard Sarena	ETNB	Common Stock	Tax liability	-3.86%			-2,979	74,231	05 Aug 2025	Direct
Quoc Le-Nguyen	ETNB	Common Stock	Tax liability	-3.67%			-522	13,694	01 Aug 2025	By Spouse
Quoc Le-Nguyen	ETNB	Common Stock	Tax liability	-2.48%			-7,680	301,684	01 Aug 2025	Direct
Harry H. Mansbach	ETNB	Common Stock	Tax liability	-2.47%			-7,680	302,656	01 Aug 2025	Direct
Ryan Martins	ETNB	Common Stock	Tax liability	-2.94%			-7,680	253,496	01 Aug 2025	Direct
Francis Willard Sarena	ETNB	Common Stock	Tax liability	-3.99%			-3,206	77,210	01 Aug 2025	Direct
Rohan Palekar	ETNB	Common Stock	Tax liability	-6.46%			-55,836	808,070	01 Aug 2025	Direct
Quoc Le-Nguyen	ETNB	Common Stock	Sale	-3.27%	$115,280	$11.02	-10,461	309,364	15 Jul 2025	Direct
Ryan Martins	ETNB	Common Stock	Tax liability	-3.15%			-8,498	261,176	12 Jun 2025	Direct
Harry H. Mansbach	ETNB	Common Stock	Tax liability	-2.67%			-8,498	310,336	12 Jun 2025	Direct
Quoc Le-Nguyen	ETNB	Common Stock	Tax liability	-3.62%			-534	14,216	12 Jun 2025	By Spouse
Quoc Le-Nguyen	ETNB	Common Stock	Tax liability	-2.59%			-8,498	319,825	12 Jun 2025	Direct
Quoc Le-Nguyen	ETNB	Common Stock	Sale	-4.46%	$91,208	$5.95	-15,329	328,323	15 Apr 2025	Direct

* An asterisk sign (*) next to the price indicates that the price is likely invalid.