Comparable stake leader
VANGUARD GROUP INC
SEC ownership of 89bio, Inc.
Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001785173.
Disclosed value leader
SUVRETTA CAPITAL MANAGEMENT, LLC
Comparable rows
5/9
Latest evidence
30 Oct 2025
- Parsed ownership sources
-
13D/G and 3/4/5
Source: Parsed SEC ownership filingsUse: Compare filing families carefully
- Largest SEC-reported holder
-
VANGUARD GROUP INC
Ranking: Comparable ownership first, then disclosed value
- Comparable ownership rows
-
5 of 9
Meaning: Rows with safely comparable ownership %
- Latest 13D/G holder
-
VANGUARD GROUP INC
Source: Latest parsed Schedule 13D/G stake
- Latest parsed ownership date
-
30 Oct 2025
Freshness: Most recent filing date in this holder set
- Issuer CIK
- 0001785173
- Issuer location
- San Francisco, CA
Ownership snapshot
CIK-linked ownership evidence from parsed SEC filings.
3 signals
Issuer
Names, identifiers, and filing context for this profile.
2 identity fields
Ownership snapshot
Top shareholders of 89bio, Inc. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
VANGUARD GROUP INC
Disclosed value leader
SUVRETTA CAPITAL MANAGEME...
Comparable rows
5/9
Latest evidence
30 Oct 2025
13D/G
3/4/5
Lead comparable stake: 5.6%
4 rows are not safely comparable across share classes.
13D/G row: VANGUARD GROUP INC
Showing 1-8 of 9 holder rows.
Quick read
VANGUARD GROUP INC leads the comparable SEC ownership view at 5.6%.
5 of 9 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens VANGUARD GROUP INC's linked filing trail.
Comparable ownership
Top 5
VANGUARD GROUP INC
5.6%
SUVRETTA CAPITAL MANAGEMENT, LLC
5.6%
JANUS HENDERSON GROUP PLC
3.6%
BIOTECHNOLOGY VALUE FUND L P
3.6%
RTW INVESTMENTS, LP
1.3%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-8 of 9 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| VANGUARD GROUP INC |
13D/G
The Vanguard Group
|
5.6%
|
$80,937,952
8,242,154 shares
|
$0 | 30 Jun 2025 |
| SUVRETTA CAPITAL MANAGEMENT, LLC |
13D/G
|
5.6%
|
$121,716,000
8,280,000 shares
|
-$93,071,712 | 30 Sep 2025 |
| JANUS HENDERSON GROUP PLC |
13D/G
|
3.6%
|
$79,060,933
5,378,185 shares
|
-$226,534,240 | 30 Sep 2025 |
| BIOTECHNOLOGY VALUE FUND L P |
13D/G
BVF PARTNERS L P/IL
|
3.6%
|
$29,903,806
4,333,885 shares
|
$0 | 31 Dec 2024 |
| RTW INVESTMENTS, LP |
13D/G
|
1.3%
|
$13,575,936
1,967,527 shares
|
$0 | 31 Mar 2025 |
| RA CAPITAL MANAGEMENT, L.P. |
3/4/5
Director, 10%+ Owner
|
— |
$36,809,857
|
— | 30 Oct 2025 |
| ORBIMED ADVISORS LLC |
3/4/5
10%+ Owner
|
—
class O/S missing
|
$21,093,397
1,829,436 shares
|
— | 25 Jan 2022 |
| Gregory Grunberg |
3/4/5
Director, 10%+ Owner
|
—
class O/S missing
|
—
27,400 shares
|
— | 09 Feb 2023 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
Forms 3/4/5 flow
Insider trading overview
Net insider flow leans to selling over the last 12 months. Net value: -$115,280.
Buys
$0
Insiders: 0
Sells
$115,280
Insiders: 1
Net
-$115,280
Shares: -10,461
Window
Last 12 months
4 rolling buckets
Buy value
Sell value
Shares: 0
Shares: 10,461
| Window (months) | Buy shares | Sell shares | Buy value | Sell value | Net value |
|---|---|---|---|---|---|
| 0-3 | 0 | 0 | $0 | $0 | $0 |
| 3-6 | 0 | 0 | $0 | $0 | $0 |
| 6-9 | 0 | 0 | $0 | $0 | $0 |
| 9-12 | 0 | 10,461 | $0 | $115,280 | -$115,280 |
Reporting owners
Insider holders from Forms 3/4/5
Showing 1-17 of 17 reporting-owner rows connected to 89bio, Inc.. Open a relationship link for the CIK-to-CIK filing trail.
Rows
17
Largest Forms 3/4/5 holder
RA CAPITAL MANAGEMENT, L.P.
Net 12M change
-$115,280
Latest report
30 Oct 2025
Recent insider transactions for 89bio, Inc.
Showing up to 300 recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | SEC-reported value | SEC-reported price | Shares | Shares owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | ETNB | Common Stock | Disposed to Issuer | -100% | -19,889,683 | 0 | 30 Oct 2025 | See Footnotes | ||
| Ra Capital Management, L.P. | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -180,450 | 0 | 30 Oct 2025 | See footnotes | ||
| Ra Capital Management, L.P. | ETNB | Pre-Funded Warrants (Right to Buy) | Disposed to Issuer | -100% | -4,331,081 | 0 | 30 Oct 2025 | See footnotes | ||
| Kathleen LaPorte | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -166,450 | 0 | 30 Oct 2025 | Direct | ||
| Michael R. Hayden | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -165,516 | 0 | 30 Oct 2025 | See footnote | ||
| Michael R. Hayden | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -80,904 | 0 | 30 Oct 2025 | Direct | ||
| Michael R. Hayden | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -233,760 | 0 | 30 Oct 2025 | Direct | ||
| Ryan Martins | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -374,295 | 0 | 30 Oct 2025 | Direct | ||
| Ryan Martins | ETNB | Common Stock | Award | 10.3% | 35,000 | 374,295 | 30 Oct 2025 | Direct | ||
| Ryan Martins | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -738,102 | 0 | 30 Oct 2025 | Direct | ||
| Steven M. Altschuler | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -213,450 | 0 | 30 Oct 2025 | Direct | ||
| Rohan Palekar | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -934,273 | 0 | 30 Oct 2025 | Direct | ||
| Rohan Palekar | ETNB | Common Stock | Award | 15.4% | 125,000 | 934,273 | 30 Oct 2025 | Direct | ||
| Rohan Palekar | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -2,599,223 | 0 | 30 Oct 2025 | Direct | ||
| Charles McWherter | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -25,000 | 0 | 30 Oct 2025 | Direct | ||
| Charles McWherter | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -124,100 | 0 | 30 Oct 2025 | Direct | ||
| Edward Morrow Atkinson III | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -148,950 | 0 | 30 Oct 2025 | Direct | ||
| Lota S. Zoth | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -186,450 | 0 | 30 Oct 2025 | Direct | ||
| Quoc Le-Nguyen | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -13,694 | 0 | 30 Oct 2025 | By Spouse | ||
| Quoc Le-Nguyen | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -351,684 | 0 | 30 Oct 2025 | Direct | ||
| Quoc Le-Nguyen | ETNB | Common Stock | Award | 16.6% | 50,000 | 351,684 | 30 Oct 2025 | Direct | ||
| Quoc Le-Nguyen | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -43,900 | 0 | 30 Oct 2025 | By Spouse | ||
| Quoc Le-Nguyen | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -829,875 | 0 | 30 Oct 2025 | Direct | ||
| Martin Babler | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -124,100 | 0 | 30 Oct 2025 | Direct | ||
| Derek DiRocco | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -19,500 | 0 | 30 Oct 2025 | See footnote | ||
| Derek DiRocco | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -160,950 | 0 | 30 Oct 2025 | Direct | ||
| Francis Willard Sarena | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -75,310 | 0 | 30 Oct 2025 | Direct | ||
| Francis Willard Sarena | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -565,000 | 0 | 30 Oct 2025 | Direct | ||
| Harry H. Mansbach | ETNB | Common Stock | Disposition pursuant to a tender of shares in a change of control transaction | -100% | -352,656 | 0 | 30 Oct 2025 | Direct | ||
| Harry H. Mansbach | ETNB | Common Stock | Award | 16.5% | 50,000 | 352,656 | 30 Oct 2025 | Direct | ||
| Harry H. Mansbach | ETNB | Stock Option (Right to Buy) | Disposed to Issuer | -100% | -954,741 | 0 | 30 Oct 2025 | Direct | ||
| Ryan Martins | ETNB | Common Stock | Options Exercise | 31.3% | 80,799 | 339,295 | 22 Oct 2025 | Direct | ||
| Ryan Martins | ETNB | Stock Option (Right to Buy) | Options Exercise | -100% | -80,799 | 0 | 22 Oct 2025 | Direct | ||
| Francis Willard Sarena | ETNB | Common Stock | Tax liability | -3.86% | -2,979 | 74,231 | 05 Aug 2025 | Direct | ||
| Quoc Le-Nguyen | ETNB | Common Stock | Tax liability | -3.67% | -522 | 13,694 | 01 Aug 2025 | By Spouse | ||
| Quoc Le-Nguyen | ETNB | Common Stock | Tax liability | -2.48% | -7,680 | 301,684 | 01 Aug 2025 | Direct | ||
| Harry H. Mansbach | ETNB | Common Stock | Tax liability | -2.47% | -7,680 | 302,656 | 01 Aug 2025 | Direct | ||
| Ryan Martins | ETNB | Common Stock | Tax liability | -2.94% | -7,680 | 253,496 | 01 Aug 2025 | Direct | ||
| Francis Willard Sarena | ETNB | Common Stock | Tax liability | -3.99% | -3,206 | 77,210 | 01 Aug 2025 | Direct | ||
| Rohan Palekar | ETNB | Common Stock | Tax liability | -6.46% | -55,836 | 808,070 | 01 Aug 2025 | Direct | ||
| Quoc Le-Nguyen | ETNB | Common Stock | Sale | -3.27% | $115,280 | $11.02 | -10,461 | 309,364 | 15 Jul 2025 | Direct |
* marks a reported price that did not pass the local price check.