Opaleye Management Inc. - 03 Dec 2025 SCHEDULE 13G/A Report for Codexis, Inc. Common Stock, par value $0.0001 per share (CDXS)

Filing Manager: Opaleye Management Inc.
Reporting Manager: Opaleye Management Inc.
Security: Codexis, Inc. Common Stock, par value $0.0001 per share
Symbol: CDXS
Shares outstanding: 90.3M shares
Disclosed Ownership: 8.99M shares
Ownership: 9.95%
Form type: SCHEDULE 13G/A
Filing time: 05 Dec 2025, 16:05:02 UTC
Date of event: 03 Dec 2025
SEC: View on sec.gov

Reporting Managers (3)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
Opaleye Management Inc.	9.95%	8.99M	0	8.99M	/s/ James Silverman	President
Opaleye, L.P.	9.75%	8.81M	0	8.81M	/s/ James Silverman	General Partner
James Silverman	9.95%	8.99M	0	8.99M	/s/ James Silverman	Individually