Opaleye Management Inc.

Holdings History for AGIOS PHARMACEUTICALS, INC. - Common stock, par value $0.0001 per share (AGIO)

Symbol: AGIO on Nasdaq
Investment type: Equity / Common stock, par value $0.0001 per share

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2018		-2.6%	$0	0	-130,000	-100%	$28.32	Q4 2018
30 Sep 2018	2.6%	0%	$10,025,000	130,000	0		$77.12	Q3 2018
30 Jun 2018	2.9%	0%	$10,949,000	130,000	0		$84.22	Q2 2018
31 Mar 2018	3%	0%	$10,631,000	130,000	0		$81.78	Q1 2018
31 Dec 2017	2.4%	0%	$7,432,000	130,000	0		$57.17	Q4 2017
30 Sep 2017	3.1%	0%	$8,677,000	130,000	0		$66.75	Q3 2017
30 Jun 2017	2.8%	0%	$6,688,000	130,000	0		$51.45	Q2 2017
31 Mar 2017	3.8%	0%	$7,592,000	130,000	0		$58.40	Q1 2017
31 Dec 2016	3.2%	0%	$5,425,000	130,000	0		$41.73	Q4 2016
30 Sep 2016	3.6%	+1.2%	$6,867,000	130,000	+45,000	+53%	$52.82	Q3 2016
30 Jun 2016	2.4%	-0.56%	$3,561,000	85,000	-20,000	-19%	$41.89	Q2 2016
31 Mar 2016	2.9%	+2.9%	$4,263,000	105,000	+105,000	NEW	$40.60	Q1 2016
30 Jun 2015		-3.9%	$0	0	-90,000	-100%	$28.32	Q2 2015
31 Mar 2015	3.9%	-1%	$8,487,000	90,000	-23,500	-21%	$94.30	Q1 2015
31 Dec 2014	6.4%	0%	$12,717,000	113,500	0		$112.04	Q4 2014
30 Sep 2014	5.4%	-0.07%	$6,963,225	113,500	-1,500	-1.3%	$61.35	Q3 2014
30 Jun 2014	4.5%	+4.5%	$5,269,000	115,000	+115,000	NEW	$45.82	Q2 2014

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.