| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Farallon Capital Partners, L.P. | 9.9% | $166,034,875 | 5,674,466 | Dapice Joshua J. | 31 Dec 2024 | |||
| BlackRock, Inc. | 7.8% | $150,100,362 | 4,513,170 | BlackRock, Inc. | 30 Jun 2025 | |||
| Paradigm Biocapital Advisors LP | 4.9% | -6% | $115,344,498 | -$6,198,499 | 2,873,555 | -5.1% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 63,492,585 | $2,545,823,532 | +$81,769,913 | $40.14 | 215 |
| 2025 Q2 | 61,683,672 | $2,051,725,997 | +$65,237,829 | $33.26 | 211 |
| 2025 Q1 | 59,963,279 | $1,757,322,194 | -$10,187,060 | $29.30 | 216 |
| 2024 Q4 | 59,832,436 | $1,966,429,716 | +$37,958,970 | $32.86 | 221 |
| 2024 Q3 | 58,096,571 | $2,582,267,784 | -$8,181,474 | $44.43 | 204 |
| 2024 Q2 | 58,132,966 | $2,506,935,894 | -$125,225,015 | $43.12 | 203 |
| 2024 Q1 | 61,946,791 | $1,811,267,450 | +$89,235,062 | $29.24 | 183 |
| 2023 Q4 | 59,884,422 | $1,333,701,271 | +$15,853,345 | $22.27 | 167 |
| 2023 Q3 | 59,110,077 | $1,463,036,585 | -$8,921,651 | $24.75 | 142 |
| 2023 Q2 | 59,366,269 | $1,679,785,246 | +$16,420,594 | $28.32 | 150 |
| 2023 Q1 | 58,996,438 | $1,355,139,176 | -$9,985,145 | $22.97 | 161 |
| 2022 Q4 | 59,442,573 | $1,669,125,079 | +$45,133,345 | $28.08 | 156 |
| 2022 Q3 | 57,972,960 | $1,639,524,356 | -$46,396,034 | $28.28 | 155 |
| 2022 Q2 | 59,017,906 | $1,308,562,484 | -$21,425,021 | $22.17 | 143 |
| 2022 Q1 | 59,895,743 | $1,743,443,247 | +$19,219,573 | $29.11 | 146 |
| 2021 Q4 | 59,210,281 | $1,947,305,194 | -$73,787,635 | $32.87 | 148 |
| 2021 Q3 | 60,890,488 | $2,810,077,563 | -$244,072,957 | $46.15 | 157 |
| 2021 Q2 | 65,926,694 | $3,632,531,095 | +$51,380,893 | $55.11 | 179 |
| 2021 Q1 | 65,233,267 | $3,366,007,585 | +$56,136,770 | $51.64 | 168 |
| 2020 Q4 | 64,981,734 | $2,817,090,446 | -$19,419,372 | $43.33 | 189 |
| 2020 Q3 | 65,869,834 | $2,304,359,620 | -$101,763,130 | $35.00 | 206 |
| 2020 Q2 | 67,492,943 | $3,609,431,770 | -$76,258,753 | $53.48 | 205 |
| 2020 Q1 | 69,390,256 | $2,461,883,479 | +$6,215,421 | $35.48 | 188 |
| 2019 Q4 | 69,034,713 | $3,296,545,303 | +$348,129,625 | $47.75 | 192 |
| 2019 Q3 | 61,888,248 | $2,005,330,307 | +$38,059,098 | $32.40 | 180 |
| 2019 Q2 | 60,668,045 | $3,025,896,532 | +$157,762,312 | $49.88 | 182 |
| 2019 Q1 | 60,134,445 | $4,055,728,260 | +$162,774,480 | $67.44 | 191 |
| 2018 Q4 | 58,006,486 | $2,674,145,349 | +$50,031,635 | $46.11 | 182 |
| 2018 Q3 | 55,625,309 | $4,289,793,406 | +$92,816,537 | $77.12 | 199 |
| 2018 Q2 | 54,418,427 | $4,583,658,355 | -$33,625,899 | $84.23 | 207 |
| 2018 Q1 | 54,830,882 | $4,483,993,749 | +$716,755,603 | $81.78 | 192 |
| 2017 Q4 | 46,986,627 | $2,686,172,197 | +$50,530,934 | $57.17 | 173 |
| 2017 Q3 | 46,056,523 | $3,074,218,539 | +$17,986,293 | $66.75 | 168 |
| 2017 Q2 | 46,127,851 | $2,373,318,886 | +$325,571,290 | $51.45 | 164 |
| 2017 Q1 | 40,972,190 | $2,392,699,790 | +$240,606,903 | $58.40 | 154 |
| 2016 Q4 | 39,019,883 | $1,628,427,134 | +$42,873,951 | $41.73 | 154 |
| 2016 Q3 | 37,828,945 | $1,997,518,488 | +$255,912,326 | $52.82 | 160 |
| 2016 Q2 | 33,999,654 | $1,424,491,193 | +$19,274,497 | $41.89 | 150 |
| 2016 Q1 | 33,779,727 | $1,371,223,373 | +$17,925,029 | $40.60 | 151 |
| 2015 Q4 | 33,010,570 | $2,143,167,128 | +$96,156,802 | $64.92 | 141 |
| 2015 Q3 | 31,391,017 | $2,215,769,820 | +$82,761,834 | $70.59 | 149 |
| 2015 Q2 | 30,124,596 | $3,347,682,014 | +$244,304,306 | $111.14 | 159 |
| 2015 Q1 | 27,958,847 | $2,636,827,051 | -$36,991,648 | $94.30 | 149 |
| 2014 Q4 | 27,657,103 | $3,098,842,918 | +$394,968,566 | $112.04 | 142 |
| 2014 Q3 | 24,482,713 | $1,502,054,443 | +$81,527,891 | $61.35 | 119 |
| 2014 Q2 | 23,591,425 | $1,080,804,790 | +$140,019,435 | $45.82 | 99 |
| 2014 Q1 | 20,545,950 | $804,373,483 | +$93,802,312 | $39.15 | 73 |