| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Farallon Capital Partners, L.P. | 9.9% | $166M | 5.67M | Dapice Joshua J. | 31 Dec 2024 | |||
| BlackRock, Inc. | 7.8% | $150M | 4.51M | BlackRock, Inc. | 30 Jun 2025 | |||
| Paradigm Biocapital Advisors LP | 4.9% | -6% | $115M | -$6.2M | 2.87M | -5.1% | Paradigm BioCapital Advisors LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 63.5M | $2.55B | +$81.8M | $40.14 | 215 |
| 2025 Q2 | 61.7M | $2.05B | +$65.2M | $33.26 | 211 |
| 2025 Q1 | 60M | $1.76B | -$10.2M | $29.30 | 216 |
| 2024 Q4 | 59.8M | $1.97B | +$38M | $32.86 | 221 |
| 2024 Q3 | 58.1M | $2.58B | -$8.18M | $44.43 | 204 |
| 2024 Q2 | 58.1M | $2.51B | -$125M | $43.12 | 203 |
| 2024 Q1 | 61.9M | $1.81B | +$89.2M | $29.24 | 183 |
| 2023 Q4 | 59.9M | $1.33B | +$15.9M | $22.27 | 167 |
| 2023 Q3 | 59.1M | $1.46B | -$8.92M | $24.75 | 142 |
| 2023 Q2 | 59.4M | $1.68B | +$16.4M | $28.32 | 150 |
| 2023 Q1 | 59M | $1.36B | -$9.99M | $22.97 | 161 |
| 2022 Q4 | 59.4M | $1.67B | +$45.1M | $28.08 | 156 |
| 2022 Q3 | 58M | $1.64B | -$46.4M | $28.28 | 155 |
| 2022 Q2 | 59M | $1.31B | -$21.4M | $22.17 | 143 |
| 2022 Q1 | 59.9M | $1.74B | +$19.2M | $29.11 | 146 |
| 2021 Q4 | 59.2M | $1.95B | -$73.8M | $32.87 | 148 |
| 2021 Q3 | 60.9M | $2.81B | -$244M | $46.15 | 157 |
| 2021 Q2 | 65.9M | $3.63B | +$51.4M | $55.11 | 179 |
| 2021 Q1 | 65.2M | $3.37B | +$56.1M | $51.64 | 168 |
| 2020 Q4 | 65M | $2.82B | -$19.4M | $43.33 | 189 |
| 2020 Q3 | 65.9M | $2.3B | -$102M | $35.00 | 206 |
| 2020 Q2 | 67.5M | $3.61B | -$76.3M | $53.48 | 205 |
| 2020 Q1 | 69.4M | $2.46B | +$6.22M | $35.48 | 188 |
| 2019 Q4 | 69M | $3.3B | +$348M | $47.75 | 192 |
| 2019 Q3 | 61.9M | $2.01B | +$38.1M | $32.40 | 180 |
| 2019 Q2 | 60.7M | $3.03B | +$158M | $49.88 | 182 |
| 2019 Q1 | 60.1M | $4.06B | +$163M | $67.44 | 191 |
| 2018 Q4 | 58M | $2.67B | +$50M | $46.11 | 182 |
| 2018 Q3 | 55.6M | $4.29B | +$92.8M | $77.12 | 199 |
| 2018 Q2 | 54.4M | $4.58B | -$33.6M | $84.23 | 207 |
| 2018 Q1 | 54.8M | $4.48B | +$717M | $81.78 | 192 |
| 2017 Q4 | 47M | $2.69B | +$50.5M | $57.17 | 173 |
| 2017 Q3 | 46.1M | $3.07B | +$18M | $66.75 | 168 |
| 2017 Q2 | 46.1M | $2.37B | +$326M | $51.45 | 164 |
| 2017 Q1 | 41M | $2.39B | +$241M | $58.40 | 154 |
| 2016 Q4 | 39M | $1.63B | +$42.9M | $41.73 | 154 |
| 2016 Q3 | 37.8M | $2B | +$256M | $52.82 | 160 |
| 2016 Q2 | 34M | $1.42B | +$19.3M | $41.89 | 150 |
| 2016 Q1 | 33.8M | $1.37B | +$17.9M | $40.60 | 151 |
| 2015 Q4 | 33M | $2.14B | +$96.2M | $64.92 | 141 |
| 2015 Q3 | 31.4M | $2.22B | +$82.8M | $70.59 | 149 |
| 2015 Q2 | 30.1M | $3.35B | +$244M | $111.14 | 159 |
| 2015 Q1 | 28M | $2.64B | -$37M | $94.30 | 149 |
| 2014 Q4 | 27.7M | $3.1B | +$395M | $112.04 | 142 |
| 2014 Q3 | 24.5M | $1.5B | +$81.5M | $61.35 | 119 |
| 2014 Q2 | 23.6M | $1.08B | +$140M | $45.82 | 99 |
| 2014 Q1 | 20.5M | $804M | +$93.8M | $39.15 | 73 |