ORBIMED ADVISORS LLC

Holdings History for Upstream Bio, Inc. - Common Stock, par value $0.001 per share (UPB)

Symbol: UPB on Nasdaq
Investment type: Equity / Common Stock, par value $0.001 per share

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025	3.3%	0%	$154,580,941	5,693,589	0		$27.15	Q4 2025
30 Sep 2025	2.6%	0%	$107,096,409	5,693,589	0		$18.81	Q3 2025
30 Jun 2025	1.6%	0%	$62,515,607	5,693,589	0		$10.98	Q2 2025
31 Mar 2025	0.84%	0%	$34,844,765	5,693,589	0		$6.12	Q1 2025
31 Dec 2024	2%	+2%	$93,602,603	5,693,589	+5,693,589	NEW	$16.44	Q4 2024

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.