Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR)
CUSIP: 86366E106
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Ordinary Shares, par value $0.0001 per share
- Shares outstanding
- 213,001,347
- Total 13F shares
- 65,776,439
- Share change
- +9,022,085
- Total reported value
- $4,580,197,295
- Put/Call ratio
- 27%
- Price per share
- $69.55
- Number of holders
- 197
- Value change
- +$791,360,837
- Number of buys
- 115
- Number of sells
- 88
Quarterly Holders Quick Answers
What is CUSIP 86366E106?
CUSIP 86366E106 identifies GPCR - Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share in SEC institutional holdings data.
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Recent filing periods for CUSIP 86366E106:
Top shareholders of GPCR - Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| FMR LLC |
13D/G
13F
|
Company |
15%
|
31,112,634
|
$2,163,883,695 | +$776,609,280 | 31 Dec 2025 | |
| WELLINGTON MANAGEMENT GROUP LLP |
13D/G
13F
|
Company |
10%
|
21,365,952
|
$1,481,942,431 | +$50,941,729 | 31 Dec 2025 | |
| Deep Track Capital, LP |
13D/G
13F
|
Company |
6%
|
12,335,346
|
$855,579,599 | -$21,646,354 | 31 Dec 2025 | |
| BIOTECHNOLOGY VALUE FUND L P |
13D/G
|
BVF PARTNERS L P/IL |
4.9%
|
10,437,066
|
$723,914,898 | +$57,243,848 | 31 Dec 2025 | |
| Avoro Capital Advisors LLC |
13D/G
13F
|
Company |
9.4%
|
16,216,665
|
$454,066,620 | $0 | 30 Sep 2025 | |
| Capital Research Global Investors |
13D/G
|
— |
3.8%
|
6,492,435
|
$168,218,991 | $0 | 31 Mar 2025 | |
| JANUS HENDERSON GROUP PLC |
13F
13D/G
|
Company |
7.7%
from 13D/G
|
4,448,826
|
$124,603,170 | — | 30 Sep 2025 | |
| BVF INC/IL |
13F
|
Company |
1.5%
|
3,203,917
|
$89,709,676 | — | 30 Sep 2025 | |
| BAKER BROS. ADVISORS LP |
13F
|
Company |
0.73%
|
1,556,109
|
$43,571,052 | — | 30 Sep 2025 | |
| Casdin Capital, LLC |
13F
|
Company |
0.73%
|
1,555,000
|
$43,540,000 | — | 30 Sep 2025 | |
| RA CAPITAL MANAGEMENT, L.P. |
13F
|
Company |
0.71%
|
1,517,418
|
$42,487,704 | — | 30 Sep 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.6%
|
1,274,551
|
$35,687,428 | — | 30 Sep 2025 | |
| AMERIPRISE FINANCIAL INC |
13F
|
Company |
0.57%
|
1,224,144
|
$34,276,032 | — | 30 Sep 2025 | |
| ORBIMED ADVISORS LLC |
13F
|
Company |
0.53%
|
1,139,300
|
$31,900,400 | — | 30 Sep 2025 | |
| TCG Crossover Management, LLC |
13F
|
Company |
0.5%
|
1,063,000
|
$29,764,000 | — | 30 Sep 2025 | |
| Siren, L.L.C. |
13F
|
Individual |
0.48%
|
1,026,811
|
$28,750,708 | — | 30 Sep 2025 | |
| Rock Springs Capital Management LP |
13F
|
Company |
0.45%
|
951,154
|
$26,632,312 | — | 30 Sep 2025 | |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
13F
|
Company |
0.41%
|
873,504
|
$24,458,112 | — | 30 Sep 2025 | |
| Logos Global Management LP |
13F
|
Company |
0.4%
|
850,000
|
$23,800,000 | — | 30 Sep 2025 | |
| PRINCIPAL FINANCIAL GROUP INC |
13F
|
Company |
0.37%
|
787,484
|
$22,049,552 | — | 30 Sep 2025 | |
| FRANKLIN RESOURCES INC |
13F
|
Company |
0.35%
|
745,734
|
$20,880,551 | — | 30 Sep 2025 | |
| PACIFIC HEIGHTS ASSET MANAGEMENT LLC |
13F
|
Company |
0.33%
|
700,000
|
$19,600,000 | — | 30 Sep 2025 | |
| Catalio Capital Management, LP |
13F
|
Company |
0.31%
|
651,810
|
$18,250,680 | — | 30 Sep 2025 | |
| Ramy Farid |
3/4/5
|
Director |
—
mixed-class rows
|
3,535,495
mixed-class rows
|
$17,176,500 | — | 07 Feb 2023 | |
| Aberdeen Group plc |
13F
|
Company |
0.28%
|
586,869
|
$16,432,332 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.27%
|
577,741
|
$16,176,758 | — | 30 Sep 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
0.24%
|
504,396
|
$14,123,088 | — | 30 Sep 2025 | |
| AMERICAN CENTURY COMPANIES INC |
13F
|
Company |
0.23%
|
486,786
|
$13,630,183 | — | 30 Sep 2025 | |
| BALYASNY ASSET MANAGEMENT L.P. |
13F
|
Company |
0.22%
|
461,553
|
$12,923,484 | — | 30 Sep 2025 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.21%
|
443,800
|
$12,426,400 | — | 30 Sep 2025 | |
| Invesco Ltd. |
13F
|
Company |
0.21%
|
443,737
|
$12,424,636 | — | 30 Sep 2025 | |
| Point72 Asset Management, L.P. |
13F
|
Company |
0.19%
|
407,700
|
$11,415,600 | — | 30 Sep 2025 | |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
13F
|
Company |
0.18%
|
373,407
|
$10,455,396 | — | 30 Sep 2025 | |
| Paradigm Biocapital Advisors LP |
13F
|
Company |
0.18%
|
372,869
|
$10,440,332 | — | 30 Sep 2025 | |
| Nantahala Capital Management, LLC |
13F
|
Company |
0.17%
|
368,553
|
$10,319,484 | — | 30 Sep 2025 | |
| ArrowMark Colorado Holdings LLC |
13F
|
Company |
0.15%
|
323,166
|
$9,048,648 | — | 30 Sep 2025 | |
| Bellevue Group AG |
13F
|
Company |
0.15%
|
315,857
|
$8,843,996 | — | 30 Sep 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
0.14%
|
289,393
|
$8,104,000 | — | 30 Sep 2025 | |
| BlackRock, Inc. |
13F
|
Company |
0.12%
|
263,938
|
$7,390,264 | — | 30 Sep 2025 | |
| TWO SIGMA ADVISERS, LP |
13F
|
Company |
0.12%
|
249,299
|
$6,980,372 | — | 30 Sep 2025 | |
| Alyeska Investment Group, L.P. |
13F
|
Company |
0.11%
|
244,848
|
$6,855,744 | — | 30 Sep 2025 | |
| READYSTATE ASSET MANAGEMENT LP |
13F
|
Company |
0.11%
|
237,188
|
$6,641,264 | — | 30 Sep 2025 | |
| HighVista Strategies LLC |
13F
|
Company |
0.11%
|
236,236
|
$6,614,608 | — | 30 Sep 2025 | |
| SECTORAL ASSET MANAGEMENT INC |
13F
|
Company |
0.1%
|
221,872
|
$6,212,416 | — | 30 Sep 2025 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13F
|
Company |
0.1%
|
213,608
|
$5,981,024 | — | 30 Sep 2025 | |
| UBS Group AG |
13F
|
Company |
0.1%
|
208,092
|
$5,826,576 | — | 30 Sep 2025 | |
| Monashee Investment Management LLC |
13F
|
Company |
0.09%
|
200,000
|
$5,600,000 | — | 30 Sep 2025 | |
| Pier Capital, LLC |
13F
|
Company |
0.09%
|
197,509
|
$5,530,252 | — | 30 Sep 2025 | |
| First Light Asset Management, LLC |
13F
|
Company |
0.09%
|
197,350
|
$5,525,800 | — | 30 Sep 2025 | |
| TWO SIGMA INVESTMENTS, LP |
13F
|
Company |
0.09%
|
182,911
|
$5,121,508 | — | 30 Sep 2025 |
Institutional Holders of Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) as of Q4 2025
As of 31 Dec 2025,
Structure Therapeutics Inc. - Ordinary Shares, par value $0.0001 per share (GPCR) was held by
197 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
65,776,439 shares.
The largest 10 holders included
FMR LLC, WELLINGTON MANAGEMENT GROUP LLP, Avoro Capital Advisors LLC, JANUS HENDERSON GROUP PLC, Deep Track Capital, LP, BVF INC/IL, MORGAN STANLEY, PRICE T ROWE ASSOCIATES INC /MD/, Driehaus Capital Management LLC, and BAKER BROS. ADVISORS LP.
This page lists
197
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
155
Q4 2025 holders
197
Holder diff
42
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.