LEXICON PHARMACEUTICALS, INC. - Common Stock, par value $0.001 per share (LXRX)

Q: What does CUSIP 528872302 represent in this 13F holders report?

CUSIP 528872302 is the security identifier for LXRX - LEXICON PHARMACEUTICALS, INC. - Common Stock, par value $0.001 per share used to aggregate holder disclosures.

Q: How many institutions held LXRX - LEXICON PHARMACEUTICALS, INC. - Common Stock, par value $0.001 per share in Q1 2026?

133 institutional investors reported LXRX - LEXICON PHARMACEUTICALS, INC. - Common Stock, par value $0.001 per share for Q1 2026. Use the holders table for investor-level position and value details.

CUSIP: 528872302

Q1 2026 13F Holders as of 31 Mar 2026

Type / Class: Equity / Common Stock, par value $0.001 per share
Shares outstanding: 444,558,533
Total 13F shares: 323,297,986
Share change: +62,911,525
Total reported value: $504,337,136
Put/Call ratio: 8.3%
Price per share: $1.56
Number of holders: 133
Value change: +$98,507,875
Number of buys: 66
Number of sells: 41

Security key

528872302

Report period

Q1 2026

Institutions

133

Top holders

LXRX full security history Ownership snapshot Full 13F holder table Previous quarter: Q4 2025 LEXICON PHARMACEUTICALS, INC. SEC filings LEXICON PHARMACEUTICALS, INC. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 528872302

Previous quarter: Q4 2025

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top shareholders of LXRX - LEXICON PHARMACEUTICALS, INC. - Common Stock, par value $0.001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder

FMR LLC

13D/G signal

FMR LLC

Evidence rows

Latest as of

02 Feb 2026

13F 13D/G 3/4/5 Lead comparable stake: 10% 13D/G row: FMR LLC Showing first 8 of 50 holder rows. Open remaining rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
FMR LLC	13F 13D/G Company 13F 13D/G	10% from 13D/G	$43,509,338 37,834,207 shares	—	31 Dec 2025
Avicenna Life Sci Master Fund LP	3/4/5 Director, 10%+ Owner 3/4/5	0.35%	$1,815,385 1,538,462 shares	—	02 Feb 2026
Artal Group S.A.	13F Company 13F	31%	$156,607,553 136,180,481 shares	—	31 Dec 2025
Siren, L.L.C.	3/4/5 13F Director, 10%+ Owner · Individual 3/4/5 13F	8.8% from 13F	$92,755,045 35,402,689 shares	—	25 Jul 2024
VANGUARD GROUP INC	13F Company 13F	2.2%	$11,047,532 9,606,549 shares	—	31 Dec 2025
MILLENNIUM MANAGEMENT LLC	13F Company 13F	1.1%	$5,544,993 4,821,733 shares	—	31 Dec 2025
BlackRock, Inc.	13F Company 13F	0.72%	$3,671,316 3,192,448 shares	—	31 Dec 2025
UBS Group AG	13F Company 13F	0.68%	$3,458,322 3,007,237 shares	—	31 Dec 2025

Show 42 additional holder rows in the full holder list

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Sessa Capital IM, L.P.	13F Company 13F	0.67%	$3,450,000 3,000,000 shares	—	31 Dec 2025
GEODE CAPITAL MANAGEMENT, LLC	13F Company 13F	0.56%	$2,876,410 2,500,022 shares	—	31 Dec 2025
CIBC Private Wealth Group LLC	13F Company 13F	0.44%	$2,242,500 1,950,000 shares	—	31 Dec 2025
JANE STREET GROUP, LLC	13F Company 13F	0.39%	$1,982,950 1,724,304 shares	—	31 Dec 2025
CITADEL ADVISORS LLC	13F Company 13F	0.38%	$1,967,621 1,710,975 shares	—	31 Dec 2025
MARSHALL WACE, LLP	13F Company 13F	0.28%	$1,451,722 1,262,367 shares	—	31 Dec 2025
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F Company 13F	0.27%	$1,388,329 1,207,242 shares	—	31 Dec 2025
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F Company 13F	0.24%	$1,213,391 1,055,123 shares	—	31 Dec 2025
GSA CAPITAL PARTNERS LLP	13F Company 13F	0.22%	$1,146,000 996,235 shares	—	31 Dec 2025
GOLDMAN SACHS GROUP INC	13F Company 13F	0.21%	$1,059,385 921,204 shares	—	31 Dec 2025
Hennion & Walsh Asset Management, Inc.	13F Company 13F	0.2%	$1,036,405 901,222 shares	—	31 Dec 2025
STATE STREET CORP	13F Company 13F	0.2%	$1,017,449 884,738 shares	—	31 Dec 2025
Ishara Investments LP	13F Company 13F	0.2%	$1,012,000 880,000 shares	—	31 Dec 2025
ACADIAN ASSET MANAGEMENT LLC	13F Company 13F	0.14%	$732,000 640,130 shares	—	31 Dec 2025
TWO SIGMA INVESTMENTS, LP	13F Company 13F	0.14%	$732,904 637,308 shares	—	31 Dec 2025
Invesco Ltd.	13F Company 13F	0.13%	$684,115 594,883 shares	—	31 Dec 2025
NORTHERN TRUST CORP	13F Company 13F	0.09%	$473,989 412,164 shares	—	31 Dec 2025
Lombard Odier SCmA Compagnie	13F Individual 13F	0.09%	$471,500 410,000 shares	—	31 Dec 2025
Point72 Asset Management, L.P.	13F Company 13F	0.06%	$326,629 284,025 shares	—	31 Dec 2025
OMERS ADMINISTRATION Corp	13F Company 13F	0.06%	$314,870 273,800 shares	—	31 Dec 2025
ExodusPoint Capital Management, LP	13F Company 13F	0.06%	$308,698 268,433 shares	—	31 Dec 2025
RENAISSANCE TECHNOLOGIES LLC	13F Company 13F	0.06%	$302,742 263,254 shares	—	31 Dec 2025
GROUP ONE TRADING LLC	13F Company 13F	0.05%	$257,954 224,308 shares	—	31 Dec 2025
BARCLAYS PLC	13F Company 13F	0.04%	$223,954 194,743 shares	—	31 Dec 2025
MORGAN STANLEY	13F Company 13F	0.04%	$221,990 193,035 shares	—	31 Dec 2025
TWO SIGMA ADVISERS, LP	13F Company 13F	0.04%	$208,124 180,977 shares	—	31 Dec 2025
Ikarian Capital, LLC	13F Company 13F	0.04%	$189,376 164,674 shares	—	31 Dec 2025
Cerity Partners LLC	13F Company 13F	0.03%	$166,686 144,944 shares	—	31 Dec 2025
AQR CAPITAL MANAGEMENT LLC	13F Company 13F	0.03%	$166,520 144,800 shares	—	31 Dec 2025
Headlands Technologies LLC	13F Company 13F	0.03%	$156,530 136,113 shares	—	31 Dec 2025
Lighthouse Investment Partners, LLC	13F Company 13F	0.03%	$145,590 126,600 shares	—	31 Dec 2025
HRT FINANCIAL LP	13F Company 13F	0.03%	$135,000 117,549 shares	—	31 Dec 2025
Monaco Asset Management SAM	13F Company 13F	0.03%	$134,766 117,188 shares	—	31 Dec 2025
TWO SIGMA SECURITIES, LLC	13F Company 13F	0.03%	$131,827 114,632 shares	—	31 Dec 2025
Graham Capital Management, L.P.	13F Company 13F	0.02%	$126,385 109,900 shares	—	31 Dec 2025
BANK OF AMERICA CORP /DE/	13F Company 13F	0.02%	$117,412 102,097 shares	—	31 Dec 2025
Hudson Bay Capital Management LP	13F Company 13F	0.02%	$115,612 100,532 shares	—	31 Dec 2025
XTX Topco Ltd	13F Company 13F	0.02%	$110,504 96,090 shares	—	31 Dec 2025
Jefferies Financial Group Inc.	13F Company 13F	0.02%	$106,410 92,530 shares	—	31 Dec 2025
CITIGROUP INC	13F Company 13F	0.02%	$105,421 91,670 shares	—	31 Dec 2025
Quarry LP	13F Company 13F	0.02%	$101,200 88,000 shares	—	31 Dec 2025
LPL Financial LLC	13F Company 13F	0.02%	$100,116 87,057 shares	—	31 Dec 2025

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q1 2026

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

133

323,297,986

Rows loaded

133

Investor	Option	Weight %	Change %	Reported value	* Price	Shares	Share Change	Activity	Report Period

* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. An asterisk next to the price means the price is likely invalid.

Compare Q1 2026 vs Q4 2025 Across Filers

Q4 2025 holders

122

Q1 2026 holders

133

Holder diff

Investor	Q4 2025 Shares	Q1 2026 Shares	Share Diff	Share Chg %	Q4 2025 value	Q1 2026 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend