13F Filings History of Siren, L.L.C.
- Latest 13F filing
- Q1 2026 - 14 May 2026
- Latest reported 13F value
- $3,607,379,030
- Largest 13F holdings
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SRRK KYMR ERAS EWTX ONC TNGX BCAX RVMD ARWR MANE XENE OLMA
+8 more
CRNX LXRX COGT STOK RCUS GPCR IRON RYTM - Form 13F summary
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- Siren, L.L.C. Form 13F history summarizes parsed U.S.-listed equity disclosures for this manager.
- Form 13F is generally due within 45 days after each calendar quarter ends.
- Siren, L.L.C. reported 100 equity holdings with a total reported market value of $3,607,379,030 for Q1 2026. Top reported holdings included SRRK, KYMR, ERAS, EWTX, and ONC.
- Manager signature
- Raymond Debbane - President
- Manager location
- Greenwich, CT
13F snapshot
Latest parsed holdings, value, and filing-period context.
1 signal
Manager
Names, identifiers, and filing context for this profile.
2 identity fields
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Holdings Value
Form 13F evidence
Quarterly portfolio filings
SEC-reported 13F quarters for this filer, ordered by the latest accepted filing.
Latest quarter
Q1 2026
Latest value
$3,607,379,030
Quarter delta
+$254,954,431
Accepted
14 May 2026, 14:07
Rows shown
1-7 of 7
| Quarter | Holdings | SEC-reported value | Bought | Sold | Net | Top Holdings | Form Type | Accepted by SEC |
|---|---|---|---|---|---|---|---|---|
| Q1 2026 | 100 | $3,607,379,030 | +$642,965,260 | -$640,612,811 | +$2,352,449 | SRRK, KYMR, ERAS, EWTX, ONC | 13F-HR | 14 May 2026, 14:07 |
| Q4 2025 | 113 | $3,352,424,599 | +$616,013,790 | -$402,720,859 | +$213,292,931 | SRRK, KYMR, ONC, EWTX, RVMD | 13F-HR | 13 Feb 2026, 10:16 |
| Q3 2025 | 115 | $2,556,293,148 | +$279,194,732 | -$214,328,056 | +$64,866,676 | SRRK, KYMR, ONC, ARWR, BCAX | 13F-HR | 13 Nov 2025, 11:06 |
| Q2 2025 | 110 | $1,932,435,966 | +$208,494,499 | -$221,396,329 | -$12,901,830 | SRRK, KYMR, ONC, IRON, CRNX | 13F-HR | 13 Aug 2025, 10:36 |
| Q1 2025 | 116 | $1,772,780,355 | +$315,053,015 | -$319,363,391 | -$4,310,376 | SRRK, ONC, KYMR, BPMC, CRNX | Restatement | 22 May 2025, 18:45 |
| Q4 2024 | 117 | $2,263,301,059 | +$418,212,788 | -$279,591,231 | +$138,621,557 | SRRK, ONC, KYMR, APLS, CRNX | 13F-HR | 14 Feb 2025, 11:06 |
| Q3 2024 | 109 | $1,998,086,577 | $0 | $0 | $0 | KYMR, BGNE, SRRK, BCAX, ARGX | 13F-HR | 13 Nov 2024, 14:52 |