Comparable stake leader
Invus Global Management, LLC
SEC ownership of LEXICON PHARMACEUTICALS, INC.
Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001062822.
Disclosed value leader
Artal Participations S.a r.l.
Comparable rows
50/50
Latest evidence
30 Jun 2026
- Public ticker
- LXRX on Nasdaq
- Parsed ownership sources
-
13D/G, 3/4/5, and 13F
Source: Parsed SEC ownership filingsUse: Compare filing families carefully
- Largest SEC-reported holder
-
Invus Global Management, LLC
Ranking: Comparable ownership first, then disclosed value
- Comparable ownership rows
-
50 of 50
Meaning: Rows with safely comparable ownership %
- Latest 13D/G holder
-
Invus Global Management, LLC
Source: Latest parsed Schedule 13D/G stake
- Latest parsed ownership date
-
30 Jun 2026
Freshness: Most recent filing date in this holder set
- Issuer CIK
- 0001062822
- Issuer location
- The Woodlands, TX
Ownership snapshot
CIK-linked ownership evidence from parsed SEC filings.
3 signals
Issuer
Names, identifiers, and filing context for this profile.
2 identity fields
Ownership snapshot
Top shareholders of LEXICON PHARMACEUTICALS, INC. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
Invus Global Management, LLC
Disclosed value leader
Artal Participations S.a ...
Comparable rows
50/50
Latest evidence
30 Jun 2026
13D/G
3/4/5
13F
Lead comparable stake: 39%
13D/G row: Invus Global Management, LLC
Showing 1-8 of 50 holder rows.
Quick read
Invus Global Management, LLC leads the comparable SEC ownership view at 39%.
50 of 50 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens Invus Global Management, LLC's linked filing trail.
Comparable ownership
Top 5
Invus Global Management, LLC
39%
FMR LLC
12%
Artal Participations S.a r.l.
40%
Administratiekantoor Westend Stic...
40%
Amaury Wittouck
40%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-8 of 50 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| Invus Global Management, LLC |
13D/G
3/4/5
Artal Participations S.a r.l. · Director, 10%+ Owner
|
39%
|
$273,243,457
175,156,062 shares
|
+$31,857,907 | 30 Apr 2026 |
| FMR LLC |
13D/G
13F
Company
|
12%
|
$124,276,907
51,782,045 shares
|
+$32,746,824 | 30 Jun 2026 |
| Artal Participations S.a r.l. |
3/4/5
Director, 10%+ Owner
|
40%
|
$299,791,711
175,156,062 shares
mixed-class rows
|
— | 30 Apr 2026 |
| Administratiekantoor Westend Stichting |
3/4/5
Director, 10%+ Owner
|
40%
|
$273,243,456
175,156,062 shares
|
— | 30 Apr 2026 |
| Amaury Wittouck |
3/4/5
Director, 10%+ Owner
|
40%
|
$273,243,456
175,156,062 shares
|
— | 30 Apr 2026 |
| Artal Group S.A. |
3/4/5
13F
Director, 10%+ Owner · Company
|
40%
|
$273,243,456
175,156,062 shares
|
— | 30 Apr 2026 |
| Artal International Management S.A. |
3/4/5
Director, 10%+ Owner
|
40%
|
$273,243,456
175,156,062 shares
|
— | 30 Apr 2026 |
| International S.c.a. Artal |
3/4/5
Director, 10%+ Owner
|
40%
|
$273,243,456
175,156,062 shares
|
— | 30 Apr 2026 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
Forms 3/4/5 flow
Insider trading overview
Net insider flow leans to buying over the last 12 months. Net value: +$2,722,625.
Buys
$2,722,625
Insiders: 2
Sells
$0
Insiders: 0
Net
+$2,722,625
Shares: +2,058,959
Window
Last 12 months
4 rolling buckets
Buy value
Sell value
Shares: 2,058,959
Shares: 0
| Window (months) | Buy shares | Sell shares | Buy value | Sell value | Net value |
|---|---|---|---|---|---|
| 0-3 | 0 | 0 | $0 | $0 | $0 |
| 3-6 | 520,497 | 0 | $722,624 | $0 | +$722,624 |
| 6-9 | 1,538,462 | 0 | $2,000,001 | $0 | +$2,000,001 |
| 9-12 | 0 | 0 | $0 | $0 | $0 |
Reporting owners
Insider holders from Forms 3/4/5
Showing 1-20 of 37 reporting-owner rows connected to LEXICON PHARMACEUTICALS, INC.. Open a relationship link for the CIK-to-CIK filing trail.
Rows
37
Largest Forms 3/4/5 holder
Artal Participations S.a r.l.
Net 12M change
+$2,722,625
Latest report
03 Jun 2026
Recent insider transactions for LEXICON PHARMACEUTICALS, INC.
Showing up to 300 recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | SEC-reported value | SEC-reported price | Shares | Shares owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Judith L. Swain | LXRX | Common Stock | Options Exercise | 104.9% | 89,312 | 174,486 | 03 Jun 2026 | Direct | ||
| Judith L. Swain | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Diane E. Sullivan | LXRX | Common Stock | Options Exercise | 242.6% | 89,312 | 126,122 | 03 Jun 2026 | Direct | ||
| Diane E. Sullivan | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Christopher J. Sobecki | LXRX | Common Stock | Options Exercise | 43.8% | 89,312 | 293,177 | 03 Jun 2026 | Direct | ||
| Christopher J. Sobecki | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Ivan H. Cheung | LXRX | Common Stock | Options Exercise | 89,312 | 89,312 | 03 Jun 2026 | Direct | |||
| Ivan H. Cheung | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Sam L. Barker | LXRX | Common Stock | Options Exercise | 71.8% | 89,312 | 213,771 | 03 Jun 2026 | Direct | ||
| Sam L. Barker | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Philippe J. Amouyal | LXRX | Common Stock | Options Exercise | 31.3% | 89,312 | 374,486 | 03 Jun 2026 | Direct | ||
| Philippe J. Amouyal | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Raymond Debbane | LXRX | Common Stock | Options Exercise | 4.69% | 89,312 | 1,995,498 | 03 Jun 2026 | Direct | ||
| Raymond Debbane | LXRX | Restricted Stock Units | Options Exercise | -100% | -89,312 | 0 | 03 Jun 2026 | Direct | ||
| Philippe J. Amouyal | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Philippe J. Amouyal | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Christopher J. Sobecki | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Christopher J. Sobecki | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Sam L. Barker | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Sam L. Barker | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Ivan H. Cheung | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Ivan H. Cheung | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Judith L. Swain | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Judith L. Swain | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Diane E. Sullivan | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Diane E. Sullivan | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Raymond Debbane | LXRX | Stock Option (Right to Buy) | Award | 43,478 | 43,478 | 01 May 2026 | Direct | |||
| Raymond Debbane | LXRX | Restricted Stock Units | Award | 35,714 | 35,714 | 01 May 2026 | Direct | |||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Common Stock | Options Exercise | 13.2% | 20,421,735 | 175,156,062 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Options Exercise | -100% | -408,435 | 0 | 30 Apr 2026 | See Footnotes | ||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Artal Participations S.a r.l. | LXRX | Series B Convertible Preferred Stock | Award | 408,435 | 408,435 | 30 Apr 2026 | See Footnotes | |||
| Wendy E. McDermott | LXRX | Common Stock | Tax liability | -19.7% | -68,107 | 277,945 | 28 Feb 2026 | Direct |
* marks a reported price that did not pass the local price check.