| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 4.4% | $218,154,766 | 1,278,975 | STATE STREET CORPORATION | 31 Dec 2024 |
As of 30 Sep 2025, 281 institutional investors reported holding 27,965,720 shares of Krystal Biotech, Inc. - COMMON STOCK (KRYS). This represents 96% of the company’s total 29,067,614 outstanding shares.
The largest institutional shareholders of Krystal Biotech, Inc. - COMMON STOCK (KRYS) together control 82% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| FMR LLC | 15% | 4,341,447 | +0.15% | 0.04% | $766,395,653 |
| BlackRock, Inc. | 13% | 3,834,128 | -0.29% | 0.01% | $676,838,615 |
| VANGUARD GROUP INC | 9.6% | 2,792,208 | -1.1% | 0.01% | $492,908,477 |
| Avoro Capital Advisors LLC | 9.6% | 2,777,777 | +4.4% | 6.3% | $490,360,974 |
| STATE STREET CORP | 4.8% | 1,395,967 | +3% | 0.01% | $246,430,055 |
| Soleus Capital Management, L.P. | 3.5% | 1,018,831 | +10% | 9.6% | $179,854,236 |
| Capital World Investors | 2.8% | 809,240 | -14% | 0.02% | $142,855,137 |
| Frazier Life Sciences Management, L.P. | 2.4% | 688,460 | 0% | 3.6% | $121,533,844 |
| Redmile Group, LLC | 2.3% | 661,388 | -0.31% | 11% | $116,754,824 |
| CITADEL ADVISORS LLC | 2.2% | 636,988 | +1743% | 0.09% | $112,447,492 |
| GEODE CAPITAL MANAGEMENT, LLC | 2.1% | 611,244 | -1.3% | 0.01% | $107,918,493 |
| Hood River Capital Management LLC | 2.1% | 606,946 | +14% | 1.3% | $107,144,177 |
| DIMENSIONAL FUND ADVISORS LP | 1.8% | 533,964 | +5.5% | 0.02% | $94,260,975 |
| BRAIDWELL LP | 1.8% | 520,401 | -28% | 2.7% | $91,866,389 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.6% | 467,058 | +79% | 0.01% | $82,451,000 |
| GOLDMAN SACHS GROUP INC | 1.2% | 348,250 | -34% | 0.01% | $61,476,572 |
| FIRST TRUST ADVISORS LP | 0.85% | 248,392 | +12% | 0.03% | $43,848,639 |
| NORTHERN TRUST CORP | 0.85% | 248,165 | -1.3% | 0.01% | $43,808,568 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.84% | 242,863 | -1.3% | 0.01% | $42,872,605 |
| MORGAN STANLEY | 0.81% | 234,577 | +0.07% | 0% | $41,409,913 |
| UBS AM, A DISTINCT BUSINESS UNIT OF UBS ASSET MANAGEMENT AMERICAS LLC | 0.7% | 202,589 | -14% | 0.01% | $35,763,036 |
| Nuveen, LLC | 0.68% | 197,378 | +5% | 0.01% | $34,843,139 |
| Pictet Asset Management Holding SA | 0.68% | 196,904 | +51% | 0.03% | $34,759,463 |
| Bank of New York Mellon Corp | 0.54% | 155,553 | -3.1% | 0% | $27,459,720 |
| Woodline Partners LP | 0.52% | 150,616 | 0% | 0.13% | $26,588,242 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 141,584 | $34,912,829 | -$160,520 | $246.54 | 30 |
| 2025 Q3 | 27,965,720 | $4,936,826,319 | +$83,533,504 | $176.53 | 281 |
| 2025 Q2 | 27,659,439 | $3,802,977,476 | -$846,440 | $137.46 | 274 |
| 2025 Q1 | 27,342,861 | $4,929,918,497 | -$51,223,771 | $180.30 | 298 |
| 2024 Q4 | 27,774,030 | $4,351,782,009 | -$92,533,890 | $156.66 | 264 |
| 2024 Q3 | 28,280,954 | $5,147,915,246 | -$55,463,849 | $182.03 | 281 |
| 2024 Q2 | 28,529,838 | $5,239,051,095 | +$658,436,118 | $183.64 | 245 |
| 2024 Q1 | 25,223,190 | $4,487,798,716 | +$175,442,652 | $177.93 | 233 |
| 2023 Q4 | 24,418,337 | $3,029,453,570 | +$42,716,131 | $124.06 | 194 |
| 2023 Q3 | 23,797,985 | $2,760,663,293 | +$92,606,023 | $116.00 | 187 |
| 2023 Q2 | 23,039,160 | $2,704,675,917 | +$256,730,169 | $117.40 | 182 |
| 2023 Q1 | 20,979,177 | $1,678,957,589 | +$9,326,151 | $80.06 | 159 |
| 2022 Q4 | 20,961,146 | $1,660,575,264 | -$15,716,124 | $79.22 | 153 |
| 2022 Q3 | 20,879,536 | $1,455,390,527 | +$2,509,281 | $69.70 | 141 |
| 2022 Q2 | 20,782,487 | $1,364,495,044 | +$17,501,639 | $65.66 | 129 |
| 2022 Q1 | 20,551,109 | $1,367,525,309 | +$24,889,158 | $66.54 | 129 |
| 2021 Q4 | 19,309,579 | $1,350,723,574 | +$209,084,528 | $69.95 | 135 |
| 2021 Q3 | 16,287,424 | $850,358,590 | -$12,114,445 | $52.21 | 112 |
| 2021 Q2 | 16,400,636 | $1,115,239,700 | -$7,228,383 | $68.00 | 113 |
| 2021 Q1 | 16,474,358 | $1,268,577,569 | +$201,515,888 | $77.04 | 113 |
| 2020 Q4 | 13,913,023 | $835,272,340 | -$16,214,267 | $60.00 | 107 |
| 2020 Q3 | 14,383,109 | $619,123,442 | +$11,279,105 | $43.05 | 98 |
| 2020 Q2 | 14,124,381 | $585,026,548 | +$106,373,347 | $41.42 | 108 |
| 2020 Q1 | 11,507,819 | $497,600,700 | -$9,385,943 | $43.24 | 88 |
| 2019 Q4 | 11,391,925 | $630,888,478 | +$15,766,941 | $55.38 | 89 |
| 2019 Q3 | 11,182,639 | $388,328,616 | +$48,273,351 | $34.73 | 83 |
| 2019 Q2 | 9,765,134 | $393,197,420 | +$130,560,730 | $40.27 | 75 |
| 2019 Q1 | 6,652,555 | $218,869,000 | +$15,470,940 | $32.90 | 56 |
| 2018 Q4 | 6,208,589 | $129,016,000 | +$73,086,744 | $20.78 | 45 |
| 2018 Q3 | 2,717,290 | $47,597,000 | +$6,006,830 | $17.58 | 21 |
| 2018 Q2 | 2,390,244 | $35,543,000 | -$7,828,421 | $14.87 | 16 |
| 2018 Q1 | 3,076,255 | $31,040,000 | -$1,629,988 | $10.09 | 12 |
| 2017 Q4 | 3,236,349 | $34,047,000 | +$1,027,245 | $10.52 | 13 |
| 2017 Q3 | 3,142,571 | $31,331,000 | +$31,331,000 | $9.97 | 13 |