Krystal Biotech, Inc. - Common Stock, $0.00001 par value ("Common Stock") (KRYS)
CUSIP: 501147102
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Common Stock, $0.00001 par value ("Common Stock")
- Shares outstanding
- 29,463,330
- Total 13F shares
- 28,422,214
- Share change
- +281,754
- Total reported value
- $7,006,786,218
- Put/Call ratio
- 41%
- Price per share
- $246.54
- Number of holders
- 331
- Value change
- +$81,339,251
- Number of buys
- 171
- Number of sells
- 133
Quarterly Holders Quick Answers
What is CUSIP 501147102?
CUSIP 501147102 identifies KRYS - Krystal Biotech, Inc. - Common Stock, $0.00001 par value ("Common Stock") in SEC institutional holdings data.
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Recent filing periods for CUSIP 501147102:
Top shareholders of KRYS - Krystal Biotech, Inc. - Common Stock, $0.00001 par value ("Common Stock") (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| FMR LLC |
13F
|
Company |
15%
|
4,341,447
|
$766,395,653 | — | 30 Sep 2025 | |
| BlackRock, Inc. |
13F
|
Company |
13%
|
3,834,128
|
$676,838,615 | — | 30 Sep 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
9.5%
|
2,792,208
|
$492,908,477 | — | 30 Sep 2025 | |
| Avoro Capital Advisors LLC |
13F
|
Company |
9.4%
|
2,777,777
|
$490,360,974 | — | 30 Sep 2025 | |
| STATE STREET CORP |
13F
13D/G
|
Company · STATE STREET CORPORATION |
4.4%
from 13D/G
|
1,395,967
|
$246,430,055 | — | 30 Sep 2025 | |
| Soleus Capital Management, L.P. |
13F
|
Company |
3.5%
|
1,018,831
|
$179,854,236 | — | 30 Sep 2025 | |
| Capital World Investors |
13F
|
Company |
2.7%
|
809,240
|
$142,855,137 | — | 30 Sep 2025 | |
| Frazier Life Sciences Management, L.P. |
13F
|
Company |
2.3%
|
688,460
|
$121,533,844 | — | 30 Sep 2025 | |
| Redmile Group, LLC |
13F
|
Company |
2.2%
|
661,388
|
$116,754,824 | — | 30 Sep 2025 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
2.2%
|
636,988
|
$112,447,492 | — | 30 Sep 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
2.1%
|
611,244
|
$107,918,493 | — | 30 Sep 2025 | |
| Hood River Capital Management LLC |
13F
|
Company |
2.1%
|
606,946
|
$107,144,177 | — | 30 Sep 2025 | |
| DIMENSIONAL FUND ADVISORS LP |
13F
|
Company |
1.8%
|
533,964
|
$94,260,975 | — | 30 Sep 2025 | |
| BRAIDWELL LP |
13F
|
Company |
1.8%
|
520,401
|
$91,866,389 | — | 30 Sep 2025 | |
| PRICE T ROWE ASSOCIATES INC /MD/ |
13F
|
Company |
1.6%
|
467,058
|
$82,451,000 | — | 30 Sep 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
1.2%
|
348,250
|
$61,476,572 | — | 30 Sep 2025 | |
| FIRST TRUST ADVISORS LP |
13F
|
Company |
0.84%
|
248,392
|
$43,848,639 | — | 30 Sep 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.84%
|
248,165
|
$43,808,568 | — | 30 Sep 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.82%
|
242,863
|
$42,872,605 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
|
Company |
0.8%
|
234,578
|
$41,410,202 | — | 30 Sep 2025 | |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
13F
|
Company |
0.69%
|
202,589
|
$35,763,036 | — | 30 Sep 2025 | |
| Nuveen, LLC |
13F
|
Company |
0.67%
|
197,378
|
$34,843,139 | — | 30 Sep 2025 | |
| Pictet Asset Management Holding SA |
13F
|
Company |
0.67%
|
196,904
|
$34,759,463 | — | 30 Sep 2025 | |
| Bank of New York Mellon Corp |
13F
|
Company |
0.53%
|
155,553
|
$27,459,720 | — | 30 Sep 2025 | |
| Woodline Partners LP |
13F
|
Company |
0.51%
|
150,616
|
$26,588,242 | — | 30 Sep 2025 | |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
13F
|
Company |
0.51%
|
149,302
|
$26,356,282 | — | 30 Sep 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
0.5%
|
148,713
|
$26,252,306 | — | 30 Sep 2025 | |
| JPMORGAN CHASE & CO |
13F
|
Company |
0.5%
|
146,354
|
$25,835,872 | — | 30 Sep 2025 | |
| PRINCIPAL FINANCIAL GROUP INC |
13F
|
Company |
0.48%
|
142,843
|
$25,216,074 | — | 30 Sep 2025 | |
| BANK OF AMERICA CORP /DE/ |
13F
|
Company |
0.47%
|
137,995
|
$24,360,258 | — | 30 Sep 2025 | |
| UBS Group AG |
13F
|
Company |
0.44%
|
130,173
|
$22,979,439 | — | 30 Sep 2025 | |
| MARSHALL WACE, LLP |
13F
|
Company |
0.44%
|
128,960
|
$22,765,310 | — | 30 Sep 2025 | |
| TimesSquare Capital Management, LLC |
13F
|
Company |
0.4%
|
118,514
|
$20,921,276 | — | 30 Sep 2025 | |
| S Squared Technology, LLC |
13F
|
Company |
0.37%
|
109,215
|
$19,279,724 | — | 30 Sep 2025 | |
| ORBIMED ADVISORS LLC |
13F
|
Company |
0.35%
|
102,745
|
$18,137,575 | — | 30 Sep 2025 | |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
13F
|
Company |
0.34%
|
100,431
|
$17,729,084 | — | 30 Sep 2025 | |
| VOYA INVESTMENT MANAGEMENT LLC |
13F
|
Company |
0.32%
|
93,908
|
$16,577,579 | — | 30 Sep 2025 | |
| C WorldWide Group Holding A/S |
13F
|
Company |
0.29%
|
85,809
|
$15,148,000 | — | 30 Sep 2025 | |
| SEGALL BRYANT & HAMILL, LLC |
13F
|
Company |
0.29%
|
85,263
|
$15,051,477 | — | 30 Sep 2025 | |
| BARCLAYS PLC |
13F
|
Company |
0.26%
|
75,896
|
$13,397,921 | — | 30 Sep 2025 | |
| RHUMBLINE ADVISERS |
13F
|
Company |
0.24%
|
70,552
|
$12,454,516 | — | 30 Sep 2025 | |
| READYSTATE ASSET MANAGEMENT LP |
13F
|
Company |
0.24%
|
70,349
|
$12,418,709 | — | 30 Sep 2025 | |
| Invesco Ltd. |
13F
|
Company |
0.23%
|
66,880
|
$11,806,327 | — | 30 Sep 2025 | |
| Handelsbanken Fonder AB |
13F
|
Company |
0.23%
|
66,800
|
$11,792,000 | — | 30 Sep 2025 | |
| Legal & General Group Plc |
13F
|
Company |
0.22%
|
65,815
|
$11,618,321 | — | 30 Sep 2025 | |
| RAYMOND JAMES FINANCIAL INC |
13F
|
Company |
0.22%
|
64,363
|
$11,362,000 | — | 30 Sep 2025 | |
| Skandinaviska Enskilda Banken AB (publ) |
13F
|
Company |
0.2%
|
59,978
|
$10,587,916 | — | 30 Sep 2025 | |
| Aberdeen Group plc |
13F
|
Company |
0.2%
|
59,372
|
$10,480,939 | — | 30 Sep 2025 | |
| AMERIPRISE FINANCIAL INC |
13F
|
Company |
0.19%
|
55,792
|
$9,848,960 | — | 30 Sep 2025 | |
| VICTORY CAPITAL MANAGEMENT INC |
13F
|
Company |
0.19%
|
54,816
|
$9,676,669 | — | 30 Sep 2025 |
Institutional Holders of Krystal Biotech, Inc. - Common Stock, $0.00001 par value ("Common Stock") (KRYS) as of Q4 2025
As of 31 Dec 2025,
Krystal Biotech, Inc. - Common Stock, $0.00001 par value ("Common Stock") (KRYS) was held by
331 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
28,422,214 shares.
The largest 10 holders included
FMR LLC, BlackRock, Inc., Avoro Capital Advisors LLC, VANGUARD GROUP INC, STATE STREET CORP, Soleus Capital Management, L.P., Capital World Investors, Redmile Group, LLC, Hood River Capital Management LLC, and GEODE CAPITAL MANAGEMENT, LLC.
This page lists
331
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
281
Q4 2025 holders
331
Holder diff
50
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.