Security key
48576U205
Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)
CUSIP: 48576U205
Q1 2026 13F Holders as of 31 Mar 2026
- Security type / class
- Equity / Common Stock, par value $0.0001 per share
- Total 13F shares
- 17,581,515
- Total 13F value
- $97,927,900
- Share change
- +7,822,113
- Put/Call ratio
- 55%
- SEC-reported price per share
- $5.57
- Number of holders
- 76
- Value change
- +$39,559,074
- Number of buys
- 51
- Number of sells
- 23
- Shares outstanding
- 22,759,596
Holder snapshot
7 signals
Open additional details 1 more signal available
Security identity
Names, identifiers, and filing context for this profile.
1 source field
Report period
Q1 2026
Institutions
76
Top holders
10
KPTI full security history
Ownership snapshot
Full 13F holder table
Karyopharm Therapeutics Inc. SEC filings
Karyopharm Therapeutics Inc. company facts
Broader feeds
Ownership snapshot
Top reported holders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
RA CAPITAL MANAGEMENT, L.P.
Disclosed value leader
T. Rowe Price Investment ...
Comparable rows
15/15
Latest evidence
31 Mar 2026
13D/G
13F
3/4/5
Lead comparable stake: 9.9%
13D/G row: RA CAPITAL MANAGEMENT, L.P.
Showing 1-6 of 15 holder rows.
Quick read
RA CAPITAL MANAGEMENT, L.P. leads the comparable SEC ownership view at 9.9%.
15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens RA CAPITAL MANAGEMENT, L.P.'s linked filing trail.
Comparable ownership
Top 5
RA CAPITAL MANAGEMENT, L.P.
9.9%
Commodore Capital LP
9.9%
Affinity Asset Advisors, LLC
8.6%
Adage Capital Management, L.P.
8.1%
GOLDMAN SACHS GROUP INC
5.1%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. |
13D/G
|
9.9%
|
$1,247,348
2,078,913 shares
|
$0 | 26 Mar 2026 |
| Commodore Capital LP |
13D/G
|
9.9%
|
$1,170,000
1,950,000 shares
|
$0 | 26 Mar 2026 |
| Affinity Asset Advisors, LLC |
13F
13D/G
Company
|
8.6%
from 13D/G
|
$6,547,272
889,575 shares
|
— | 31 Dec 2025 |
| Adage Capital Management, L.P. |
13D/G
|
8.1%
|
$1,093,042
1,821,736 shares
|
-$2,837,591 | 31 Mar 2026 |
| GOLDMAN SACHS GROUP INC |
13D/G
THE GOLDMAN SACHS GROUP, INC.
|
5.1%
|
$594,818
991,364 shares
|
$0 | 31 Mar 2026 |
| J. WOOD CAPITAL ADVISORS LLC |
13D/G
|
5%
|
$6,546,231
1,000,708 shares
|
$0 | 14 Oct 2025 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q1 2026
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
76
Shares
17,581,515
Rows available
76
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q1 2026 vs Q1 2026 Across Filers
Q1 2026 holders
76
Q1 2026 holders
76
Holder diff
0
| Investor | Q1 2026 Shares | Q1 2026 Shares | Share Diff | Share Chg % | Q1 2026 value | Q1 2026 value | Value change | Value Chg % |
|---|