Security key
48576U106
Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)
CUSIP: 48576U106
Q1 2022 13F Holders as of 31 Mar 2022
- Security type / class
- Equity / Common Stock, par value $0.0001 per share
- Total 13F shares
- 68,286,528
- Total 13F value
- $501,776,522
- Share change
- +14,250,811
- Put/Call ratio
- 45%
- SEC-reported price per share
- $7.37
- Number of holders
- 134
- Value change
- +$108,241,216
- Number of buys
- 65
- Number of sells
- 69
- Shares outstanding
- 22,658,403
Holder snapshot
7 signals
Open additional details 1 more signal available
Security identity
Names, identifiers, and filing context for this profile.
1 source field
Report period
Q1 2022
Institutions
134
Top holders
10
KPTI full security history
Ownership snapshot
Full 13F holder table
Newer quarter: Q3 2025
Karyopharm Therapeutics Inc. SEC filings
Karyopharm Therapeutics Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 48576U106
Recent filing periods:
Ownership snapshot
Top reported holders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
BlackRock Finance, Inc.
Disclosed value leader
BlackRock Finance, Inc.
Comparable rows
15/15
Latest evidence
31 Dec 2021
13F
Lead comparable stake: 39%
Showing 1-6 of 15 holder rows.
Quick read
BlackRock Finance, Inc. leads the comparable SEC ownership view at 39%.
15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens BlackRock Finance, Inc.'s linked filing trail.
Comparable ownership
Top 5
BlackRock Finance, Inc.
39%
STATE STREET CORP
24%
Palo Alto Investors LP
24%
VANGUARD GROUP INC
15%
Rubric Capital Management LP
12%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| BlackRock Finance, Inc. |
13F
Company
|
39%
|
$57,343,000
8,918,206 shares
|
— | 31 Dec 2021 |
| STATE STREET CORP |
13F
Company
|
24%
|
$35,453,000
5,513,680 shares
|
— | 31 Dec 2021 |
| Palo Alto Investors LP |
13F
Company
|
24%
|
$35,175,000
5,470,452 shares
|
— | 31 Dec 2021 |
| VANGUARD GROUP INC |
13F
Company
|
15%
|
$21,597,000
3,358,807 shares
|
— | 31 Dec 2021 |
| Rubric Capital Management LP |
13F
Company
|
12%
|
$17,891,000
2,782,443 shares
|
— | 31 Dec 2021 |
| ALKEON CAPITAL MANAGEMENT LLC |
13F
Company
|
8.7%
|
$12,613,000
1,961,588 shares
|
— | 31 Dec 2021 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q1 2022
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
134
Shares
68,286,528
Rows available
134
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q1 2022 vs Q4 2025 Across Filers
Q4 2025 holders
0
Q1 2022 holders
134
Holder diff
134
| Investor | Q4 2025 Shares | Q1 2022 Shares | Share Diff | Share Chg % | Q4 2025 value | Q1 2022 value | Value change | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend