Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q: What does CUSIP 48576U106 represent in this 13F holders report?

CUSIP 48576U106 is the security identifier for KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in Q4 2021?

138 institutional investors reported KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share for Q4 2021. Use the holders table for investor-level position and value details.

CUSIP: 48576U106

Q4 2021 13F Holders as of 31 Dec 2021

Type / Class: Equity / Common Stock, par value $0.0001 per share
Shares outstanding: 22,242,217
Total 13F shares: 54,170,305
Share change: -565,704
Total reported value: $347,414,468
Put/Call ratio: 342%
Price per share: $6.43
Number of holders: 138
Value change: -$3,383,122
Number of buys: 73
Number of sells: 62

Quarterly Holders Quick Answers

What is CUSIP 48576U106?
CUSIP 48576U106 identifies KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in SEC institutional holdings data.

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Explore More Reporting Periods

Jump to adjacent filing periods for faster comparison and easier crawl discovery.

Newer quarter: Q1 2022
Previous quarter: Q3 2021

Recent filing periods for CUSIP 48576U106:

Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024 Q1 2024

Top shareholders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
BlackRock Finance, Inc.	13F	Company	40%	8,790,318	$51,160,000	—	30 Sep 2021	13F
STATE STREET CORP	13F	Company	36%	8,019,999	$46,676,000	—	30 Sep 2021	13F
Palo Alto Investors LP	13F	Company	24%	5,383,052	$31,329,000	—	30 Sep 2021	13F
VANGUARD GROUP INC	13F	Company	16%	3,642,699	$21,201,000	—	30 Sep 2021	13F
Rubric Capital Management LP	13F	Company	15%	3,375,758	$19,647,000	—	30 Sep 2021	13F
Delphi Management Partners VIII, L.L.C.	13F	Company	10%	2,263,006	$13,170,000	—	30 Sep 2021	13F
ALKEON CAPITAL MANAGEMENT LLC	13F	Company	8.8%	1,961,588	$11,416,000	—	30 Sep 2021	13F
MORGAN STANLEY	13F	Company	8.5%	1,892,933	$11,017,000	—	30 Sep 2021	13F
Lombard Odier Asset Management (Switzerland) SA	13F	Company	6.8%	1,517,804	$8,834,000	—	30 Sep 2021	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	6.3%	1,407,157	$8,189,000	—	30 Sep 2021	13F
RICE HALL JAMES & ASSOCIATES, LLC	13F	Company	6.3%	1,401,861	$8,159,000	—	30 Sep 2021	13F
C WorldWide Group Holding A/S	13F	Company	5.4%	1,200,000	$6,984,000	—	30 Sep 2021	13F
Nuveen Asset Management, LLC	13F	Company	5%	1,119,008	$6,792,000	—	30 Sep 2021	13F
FRONTIER CAPITAL MANAGEMENT CO LLC	13F	Company	5%	1,102,427	$6,416,000	—	30 Sep 2021	13F
TWO SIGMA INVESTMENTS, LP	13F	Company	4.9%	1,096,683	$6,383,000	—	30 Sep 2021	13F
TWO SIGMA ADVISERS, LP	13F	Company	4.9%	1,082,000	$6,297,000	—	30 Sep 2021	13F
GOLDMAN SACHS GROUP INC	13F	Company	4.4%	985,382	$5,735,000	—	30 Sep 2021	13F
NORTHERN TRUST CORP	13F	Company	3.4%	767,018	$4,464,000	—	30 Sep 2021	13F
S.c.a. Candriam	13F	Individual	3.2%	717,624	$4,176,000	—	30 Sep 2021	13F
UBS Group AG	13F	Company	2.7%	608,485	$3,541,000	—	30 Sep 2021	13F
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F	Company	2.4%	540,393	$3,145,000	—	30 Sep 2021	13F
RENAISSANCE TECHNOLOGIES LLC	13F	Company	2.2%	495,400	$2,883,000	—	30 Sep 2021	13F
BNP PARIBAS FINANCIAL MARKETS	13F	Company	2.1%	468,241	$2,725,163	—	30 Sep 2021	13F
JPMORGAN CHASE & CO	13F	Company	2.1%	464,921	$2,705,000	—	30 Sep 2021	13F
Hennion & Walsh Asset Management, Inc.	13F	Company	1.8%	407,474	$2,371,000	—	30 Sep 2021	13F
MACQUARIE GROUP LTD	13F	Company	1.7%	382,041	$2,224,000	—	30 Sep 2021	13F
Rafferty Asset Management, LLC	13F	Company	1.7%	370,983	$2,159,000	—	30 Sep 2021	13F
Bank of New York Mellon Corp	13F	Company	1.4%	302,501	$1,760,000	—	30 Sep 2021	13F
PARAMETRIC PORTFOLIO ASSOCIATES LLC	13F	Company	1.3%	293,130	$1,706,000	—	30 Sep 2021	13F
JENNISON ASSOCIATES LLC	13F	Company	1.2%	270,092	$1,572,000	—	30 Sep 2021	13F
Birchview Capital, LP	13F	Company	1.1%	246,000	$1,432,000	—	30 Sep 2021	13F
CITIGROUP INC	13F	Company	1.1%	243,229	$1,416,000	—	30 Sep 2021	13F
BANK OF AMERICA CORP /DE/	13F	Company	1.1%	235,911	$1,373,000	—	30 Sep 2021	13F
DEUTSCHE BANK AG\	13F	Company	1%	224,636	$1,307,000	—	30 Sep 2021	13F
CITADEL ADVISORS LLC	13F	Company	0.99%	220,777	$1,285,000	—	30 Sep 2021	13F
BALYASNY ASSET MANAGEMENT L.P.	13F	Company	0.9%	200,412	$1,166,000	—	30 Sep 2021	13F
TUDOR INVESTMENT CORP ET AL	13F	Company	0.87%	192,931	$1,123,000	—	30 Sep 2021	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	0.85%	188,149	$1,096,000	—	30 Sep 2021	13F
GSA CAPITAL PARTNERS LLP	13F	Company	0.8%	176,996	$1,030,000	—	30 Sep 2021	13F
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC	13F	Company	0.65%	144,270	$840,000	—	30 Sep 2021	13F
AlphaCentric Advisors LLC	13F	Company	0.61%	136,000	$792,000	—	30 Sep 2021	13F
Allianz Asset Management GmbH	13F	Company	0.6%	132,948	$774,000	—	30 Sep 2021	13F
BARCLAYS PLC	13F	Company	0.6%	132,389	$770,000	—	30 Sep 2021	13F
Swiss National Bank	13F	Company	0.59%	131,650	$766,000	—	30 Sep 2021	13F
VIRGINIA RETIREMENT SYSTEMS ET Al	13F	Company	0.55%	122,300	$712,000	—	30 Sep 2021	13F
ALLIANCEBERNSTEIN L.P.	13F	Company	0.52%	115,830	$674,000	—	30 Sep 2021	13F
RHUMBLINE ADVISERS	13F	Company	0.43%	96,191	$560,000	—	30 Sep 2021	13F
Cubist Systematic Strategies, LLC	13F	Company	0.43%	95,994	$559,000	—	30 Sep 2021	13F
STATE OF WISCONSIN INVESTMENT BOARD	13F	Company	0.43%	95,400	$555,000	—	30 Sep 2021	13F
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	13F	Company	0.4%	87,951	$512,000	—	30 Sep 2021	13F

Institutional Holders of Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) as of Q4 2021

As of 31 Dec 2021, Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) was held by 138 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 54,170,305 shares. The largest 10 holders included BlackRock Inc., STATE STREET CORP, Palo Alto Investors LP, VANGUARD GROUP INC, Rubric Capital Management LP, ALKEON CAPITAL MANAGEMENT LLC, FRONTIER CAPITAL MANAGEMENT CO LLC, Lombard Odier Asset Management (Switzerland) SA, MILLENNIUM MANAGEMENT LLC, and C WorldWide Group Holding A/S. This page lists 138 institutional shareholders reporting positions in this security for the Q4 2021 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2021 vs Q3 2021 Across Filers

Q3 2021 holders

130

Q4 2021 holders

138

Holder diff

Investor	Q3 2021 Shares	Q4 2021 Shares	Share Diff	Share Chg %	Q3 2021 Value $	Q4 2021 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.