Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q: What does CUSIP 48576U106 represent in this 13F holders report?

CUSIP 48576U106 is the security identifier for KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in Q4 2021?

138 institutional investors reported KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share for Q4 2021. Use the holders table for investor-level position and value details.

CUSIP: 48576U106

Q4 2021 13F Holders as of 31 Dec 2021

Security type / class: Equity / Common Stock, par value $0.0001 per share
Total 13F shares: 54,170,305
Total 13F value: $347,414,468
Share change: -565,704
Put/Call ratio: 342%
SEC-reported price per share: $6.43
Number of holders: 138
Value change: -$3,383,122
Number of buys: 73
Number of sells: 62
Shares outstanding: 22,658,403

Security key

48576U106

Report period

Q4 2021

Institutions

138

Top holders

KPTI full security history Ownership snapshot Full 13F holder table Newer quarter: Q3 2025 Karyopharm Therapeutics Inc. SEC filings Karyopharm Therapeutics Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 48576U106

Newer quarter: Q3 2025

Recent filing periods:

Q2 2026 Q1 2026 Q4 2025 Q3 2025

Ownership snapshot

Top reported holders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

BlackRock Finance, Inc.

Disclosed value leader

BlackRock Finance, Inc.

Comparable rows

0/15

Latest evidence

30 Sep 2021

13F Highest disclosed value: $51,160,000 15 rows are not safely comparable across share classes. Showing 1-6 of 15 holder rows.

Quick read

BlackRock Finance, Inc. has the largest disclosed position value at $51.16M.

0 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens BlackRock Finance, Inc.'s linked filing trail.

Disclosed position value Top 5

BlackRock Finance, Inc. $51.16M

STATE STREET CORP $46.68M

Palo Alto Investors LP $31.33M

VANGUARD GROUP INC $21.2M

Rubric Capital Management LP $19.65M

Value bars compare disclosed positions; verify each figure against the linked filing evidence.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
BlackRock Finance, Inc.	13F Company 13F	— denominator unverified	$51,160,000 8,790,318 shares	—	30 Sep 2021
STATE STREET CORP	13F Company 13F	— denominator unverified	$46,676,000 8,019,999 shares	—	30 Sep 2021
Palo Alto Investors LP	13F Company 13F	— denominator unverified	$31,329,000 5,383,052 shares	—	30 Sep 2021
VANGUARD GROUP INC	13F Company 13F	— denominator unverified	$21,201,000 3,642,699 shares	—	30 Sep 2021
Rubric Capital Management LP	13F Company 13F	— denominator unverified	$19,647,000 3,375,758 shares	—	30 Sep 2021
Delphi Management Partners VIII, L.L.C.	13F Company 13F	— denominator unverified	$13,170,000 2,263,006 shares	—	30 Sep 2021

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2021

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

138

54,170,305

Rows available

138

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2021 vs Q1 2026 Across Filers

Q1 2026 holders

Q4 2021 holders

138

Holder diff

137

Investor	Q1 2026 Shares	Q4 2021 Shares	Share Diff	Share Chg %	Q1 2026 value	Q4 2021 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend