Security key
48576U106
Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)
CUSIP: 48576U106
Q1 2025 13F Holders as of 31 Mar 2025
- Security type / class
- Equity / Common Stock, par value $0.0001 per share
- Total 13F shares
- 352,017
- Total 13F value
- $1,316,544
- Share change
- -59,247,038
- SEC-reported price per share
- $3.74
- Number of holders
- 2
- Value change
- -$55,318,808
- Number of sells
- 86
- Shares outstanding
- 22,658,403
Holder snapshot
5 signals
Security identity
Names, identifiers, and filing context for this profile.
1 source field
Report period
Q1 2025
Institutions
2
Top holders
2
KPTI full security history
Ownership snapshot
Full 13F holder table
Newer quarter: Q3 2025
Karyopharm Therapeutics Inc. SEC filings
Karyopharm Therapeutics Inc. company facts
Broader feeds
Reporting periods
Holder history for CUSIP 48576U106
Recent filing periods:
Ownership snapshot
Top reported holders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
VANGUARD GROUP INC
Disclosed value leader
VANGUARD GROUP INC
Comparable rows
15/15
Latest evidence
31 Dec 2024
13F
Lead comparable stake: 34%
Showing 1-6 of 15 holder rows.
Quick read
VANGUARD GROUP INC leads the comparable SEC ownership view at 34%.
15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens VANGUARD GROUP INC's linked filing trail.
Comparable ownership
Top 5
VANGUARD GROUP INC
34%
ADAGE CAPITAL PARTNERS GP, L.L.C.
28%
Palo Alto Investors LP
22%
BlackRock, Inc.
17%
MORGAN STANLEY
16%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-6 of 15 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| VANGUARD GROUP INC |
13F
Company
|
34%
|
$5,174,430
7,654,482 shares
|
— | 31 Dec 2024 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
13F
Company
|
28%
|
$4,274,109
6,319,842 shares
|
— | 31 Dec 2024 |
| Palo Alto Investors LP |
13F
Company
|
22%
|
$3,318,605
4,907,001 shares
|
— | 31 Dec 2024 |
| BlackRock, Inc. |
13F
Company
|
17%
|
$2,548,889
3,768,875 shares
|
— | 31 Dec 2024 |
| MORGAN STANLEY |
13F
Company
|
16%
|
$2,375,969
3,513,188 shares
|
— | 31 Dec 2024 |
| CITADEL ADVISORS LLC |
13F
Company
|
14%
|
$2,099,011
3,103,669 shares
|
— | 31 Dec 2024 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
13F holder rows
Institutional holders as of Q1 2025
Investor-level positions for this CUSIP, loaded as an interactive table.
Institutions
2
Shares
352,017
Rows available
2
| Investor | Option | Weight % | Change % | SEC-reported value | * Price | Shares | Share Change | Activity | Report Period |
|---|
* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.
Compare Q1 2025 vs Q1 2026 Across Filers
Q1 2026 holders
1
Q1 2025 holders
2
Holder diff
1
| Investor | Q1 2026 Shares | Q1 2025 Shares | Share Diff | Share Chg % | Q1 2026 value | Q1 2025 value | Value change | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend