Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q: What does CUSIP 48576U106 represent in this 13F holders report?

CUSIP 48576U106 is the security identifier for KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in Q1 2020?

135 institutional investors reported KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share for Q1 2020. Use the holders table for investor-level position and value details.

CUSIP: 48576U106

Q1 2020 13F Holders as of 31 Mar 2020

Security type / class: Equity / Common Stock, par value $0.0001 per share
Shares outstanding: 22,658,403
Total 13F shares: 67,992,711
Share change: +11,296,204
Total reported value: $1,305,743,291
Put/Call ratio: 133%
Reported price per share: $19.21
Number of holders: 135
Value change: +$217,084,502
Number of buys: 80
Number of sells: 72

Security key

48576U106

Report period

Q1 2020

Institutions

135

Top holders

KPTI full security history Ownership snapshot Full 13F holder table Newer quarter: Q2 2020 Previous quarter: Q4 2019 Karyopharm Therapeutics Inc. SEC filings Karyopharm Therapeutics Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 48576U106

Newer quarter: Q2 2020 Previous quarter: Q4 2019

Recent filing periods:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Ownership snapshot

Top reported holders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder

Consonance Capital Manage...

13D/G signal

—

Evidence rows

Latest as of

31 Dec 2019

13F Lead comparable stake: 27% Showing 1-6 of 15 holder rows.

Rank 1 holder

Consonance Capital Management LP

13F

Ownership: 27%
Position: $117.46M

13F

Rank 2 holder

Avoro Capital Advisors LLC

13F

Ownership: 26%
Position: $113.1M

13F

Rank 3 holder

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Consonance Capital Management LP	13F Company 13F	27%	$117,463,000 6,127,434 shares	—	31 Dec 2019
Avoro Capital Advisors LLC	13F Company 13F	26%	$113,103,000 5,900,000 shares	—	31 Dec 2019
BlackRock Finance, Inc.	13F Company 13F	21%	$91,419,000 4,768,926 shares	—	31 Dec 2019
Palo Alto Investors LP	13F Company 13F	20%	$88,086,000 4,595,001 shares	—	31 Dec 2019
ADAGE CAPITAL PARTNERS GP, L.L.C.	13F Company 13F	17%	$72,597,000 3,787,000 shares	—	31 Dec 2019
STATE STREET CORP	13F Company 13F	14%	$61,888,000 3,228,366 shares	—	31 Dec 2019

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q1 2020

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

135

67,992,711

Rows available

135

Investor	Option	Weight %	Change %	Reported value	* Price	Shares	Share Change	Activity	Report Period

^* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that failed the local validity check.

Compare Q1 2020 vs Q4 2019 Across Filers

Q4 2019 holders

146

Q1 2020 holders

135

Holder diff

-11

Investor	Q4 2019 Shares	Q1 2020 Shares	Share Diff	Share Chg %	Q4 2019 value	Q1 2020 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend