Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI)

Q: What does CUSIP 48576U106 represent in this 13F holders report?

CUSIP 48576U106 is the security identifier for KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share used to aggregate holder disclosures.

Q: How many institutions held KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in Q4 2015?

86 institutional investors reported KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share for Q4 2015. Use the holders table for investor-level position and value details.

CUSIP: 48576U106

Q4 2015 13F Holders as of 31 Dec 2015

Type / Class: Equity / Common Stock, par value $0.0001 per share
Shares outstanding: 22,658,403
Total 13F shares: 21,560,134
Share change: -2,086,243
Total reported value: $285,674,019
Put/Call ratio: 76%
Price per share: $13.25
Number of holders: 86
Value change: -$24,016,754
Number of buys: 45
Number of sells: 34

Quarterly Holders Quick Answers

What is CUSIP 48576U106?
CUSIP 48576U106 identifies KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share in SEC institutional holdings data.

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Newer quarter: Q1 2016
Previous quarter: Q3 2015

Recent filing periods for CUSIP 48576U106:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024 Q2 2024

Top shareholders of KPTI - Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
FRANKLIN RESOURCES INC	13F	Company	25%	5,614,726	$59,124,000	—	30 Sep 2015	13F
FMR LLC	13F	Company	24%	5,356,672	$56,406,000	—	30 Sep 2015	13F
Palo Alto Investors LP	13F	Company	14%	3,085,745	$32,493,000	—	30 Sep 2015	13F
BlackRock Fund Advisors	13F	Company	4.9%	1,115,412	$11,745,000	—	30 Sep 2015	13F
MILLENNIUM MANAGEMENT LLC	13F	Company	4.5%	1,025,731	$10,801,000	—	30 Sep 2015	13F
Tekla Capital Management LLC	13F	Company	4.1%	918,866	$9,676,000	—	30 Sep 2015	13F
SECTORAL ASSET MANAGEMENT INC	13F	Company	3.1%	712,968	$7,508,000	—	30 Sep 2015	13F
VANGUARD GROUP INC	13F	Company	3.1%	698,261	$7,353,000	—	30 Sep 2015	13F
CITADEL ADVISORS LLC	13F	Company	2.6%	578,452	$6,091,000	—	30 Sep 2015	13F
ALPS ADVISORS INC	13F	Company	0.25%	55,870	$5,883,000	—	30 Sep 2015	13F
BlackRock Institutional Trust Company, N.A.	13F	Company	2.3%	509,882	$5,369,000	—	30 Sep 2015	13F
STATE STREET CORP	13F	Company	1.4%	306,029	$3,222,000	—	30 Sep 2015	13F
Cormorant Asset Management, LP	13F	Company	1.3%	300,987	$3,169,000	—	30 Sep 2015	13F
NORTHERN TRUST CORP	13F	Company	1.1%	241,254	$2,541,000	—	30 Sep 2015	13F
BAKER BROS. ADVISORS LP	13F	Company	0.96%	216,990	$2,285,000	—	30 Sep 2015	13F
WELLINGTON MANAGEMENT GROUP LLP	13F	Company	0.75%	170,018	$1,791,000	—	30 Sep 2015	13F
S.c.a. Candriam	13F	Individual	0.71%	161,100	$1,696,000	—	30 Sep 2015	13F
First Light Asset Management, LLC	13F	Company	0.68%	154,710	$1,629,000	—	30 Sep 2015	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	0.6%	136,269	$1,434,000	—	30 Sep 2015	13F
A.R.T. Advisors, LLC	13F	Company	0.6%	136,109	$1,433,000	—	30 Sep 2015	13F
MORGAN STANLEY	13F	Company	0.59%	133,433	$1,405,000	—	30 Sep 2015	13F
GUGGENHEIM CAPITAL LLC	13F	Company	0.59%	132,621	$1,397,000	—	30 Sep 2015	13F
ASCEND CAPITAL, LLC	13F	Company	0.55%	124,780	$1,314,000	—	30 Sep 2015	13F
STONERIDGE INVESTMENT PARTNERS LLC	13F	Company	0.46%	104,687	$1,102,000	—	30 Sep 2015	13F
Bank of New York Mellon Corp	13F	Company	0.46%	104,505	$1,100,000	—	30 Sep 2015	13F
DEUTSCHE BANK AG\	13F	Company	0.38%	86,873	$914,000	—	30 Sep 2015	13F
NEW YORK STATE COMMON RETIREMENT FUND	13F	Company	0.36%	81,226	$855,000	—	30 Sep 2015	13F
JPMORGAN CHASE & CO	13F	Company	0.35%	80,407	$846,000	—	30 Sep 2015	13F
BlackRock Investment Management, LLC	13F	Company	0.35%	79,646	$839,000	—	30 Sep 2015	13F
BANK OF AMERICA CORP /DE/	13F	Company	0.34%	76,786	$809,000	—	30 Sep 2015	13F
TIAA CREF INVESTMENT MANAGEMENT LLC	13F	Company	0.34%	76,208	$802,000	—	30 Sep 2015	13F
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F	Company	0.3%	67,699	$713,000	—	30 Sep 2015	13F
PICTET ASSET MANAGEMENT LTD	13F	Company	0.29%	64,600	$680,000	—	30 Sep 2015	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	0.25%	57,180	$603,000	—	30 Sep 2015	13F
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	13F	Company	0.24%	54,937	$578,000	—	30 Sep 2015	13F
D. E. Shaw & Co., Inc.	13F	Company	0.21%	48,700	$513,000	—	30 Sep 2015	13F
TCW GROUP INC	13F	Company	0.19%	42,481	$447,000	—	30 Sep 2015	13F
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	13F	Company	0.19%	42,080	$443,000	—	30 Sep 2015	13F
New Leaf Venture Partners, L.L.C.	13F	Company	0.18%	40,977	$431,000	—	30 Sep 2015	13F
Connor, Clark & Lunn Investment Management Ltd.	13F	Company	0.18%	40,075	$422,000	—	30 Sep 2015	13F
ALLIANCEBERNSTEIN L.P.	13F	Company	0.16%	37,027	$390,000	—	30 Sep 2015	13F
TEACHERS ADVISORS, LLC	13F	Company	0.15%	33,726	$355,000	—	30 Sep 2015	13F
HIGHBRIDGE CAPITAL MANAGEMENT LLC	13F	Company	0.15%	33,626	$354,000	—	30 Sep 2015	13F
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC)	13F	Company	0.13%	30,000	$316,000	—	30 Sep 2015	13F
TOCQUEVILLE ASSET MANAGEMENT L.P.	13F	Company	0.13%	30,000	$316,000	—	30 Sep 2015	13F
ProShare Advisors LLC	13F	Company	0.13%	29,441	$310,000	—	30 Sep 2015	13F
Swiss National Bank	13F	Company	0.12%	27,900	$294,000	—	30 Sep 2015	13F
RHUMBLINE ADVISERS	13F	Company	0.09%	20,746	$218,000	—	30 Sep 2015	13F
Deutsche Girozentrale DekaBank	13F	Individual	0.08%	18,000	$190,000	—	30 Sep 2015	13F
BALYASNY ASSET MANAGEMENT L.P.	13F	Company	0.08%	17,100	$180,000	—	30 Sep 2015	13F

Institutional Holders of Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) as of Q4 2015

As of 31 Dec 2015, Karyopharm Therapeutics Inc. - Common Stock, par value $0.0001 per share (KPTI) was held by 86 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 21,560,134 shares. The largest 10 holders included FMR LLC, FRANKLIN RESOURCES INC, Palo Alto Investors, LLC, MILLENNIUM MANAGEMENT LLC, BlackRock Fund Advisors, VANGUARD GROUP INC, BlackRock Institutional Trust Company, N.A., Tekla Capital Management LLC, STATE STREET CORP, and NORTHERN TRUST CORP. This page lists 86 institutional shareholders reporting positions in this security for the Q4 2015 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2015 vs Q3 2015 Across Filers

Q3 2015 holders

Q4 2015 holders

Holder diff

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Investor	Q3 2015 Shares	Q4 2015 Shares	Share Diff	Share Chg %	Q3 2015 Value $	Q4 2015 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.