Comparable stake leader
RTW INVESTMENTS, LP
SEC ownership of Milestone Pharmaceuticals Inc.
Top holders, 13D/G large-stake signals, insider positions, and transaction flow tied to CIK 0001408443.
Disclosed value leader
RTW INVESTMENTS, LP
Comparable rows
50/50
Latest evidence
31 Mar 2026
- Public ticker
- MIST on Nasdaq
- Parsed ownership sources
-
3/4/5, 13D/G, and 13F
Source: Parsed SEC ownership filingsUse: Compare filing families carefully
- Largest SEC-reported holder
-
RTW INVESTMENTS, LP
Ranking: Comparable ownership first, then disclosed value
- Comparable ownership rows
-
50 of 50
Meaning: Rows with safely comparable ownership %
- Latest 13D/G holder
-
RTW INVESTMENTS, LP
Source: Latest parsed Schedule 13D/G stake
- Latest parsed ownership date
-
31 Mar 2026
Freshness: Most recent filing date in this holder set
- Issuer CIK
- 0001408443
- Issuer location
- Montreal, Quebec, Canada
Ownership snapshot
CIK-linked ownership evidence from parsed SEC filings.
3 signals
Issuer
Names, identifiers, and filing context for this profile.
2 identity fields
Ownership snapshot
Top shareholders of Milestone Pharmaceuticals Inc. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.
Comparable stake leader
RTW INVESTMENTS, LP
Disclosed value leader
RTW INVESTMENTS, LP
Comparable rows
50/50
Latest evidence
31 Mar 2026
3/4/5
13D/G
13F
Lead comparable stake: 9.9%
13D/G row: RTW INVESTMENTS, LP
Showing 1-8 of 50 holder rows.
Quick read
RTW INVESTMENTS, LP leads the comparable SEC ownership view at 9.9%.
50 of 50 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.
Open SEC evidence
Opens RTW INVESTMENTS, LP's linked filing trail.
Comparable ownership
Top 5
RTW INVESTMENTS, LP
9.9%
Propel Bio Management, LLC
9.9%
Adage Capital Management, L.P.
6.4%
Trails Edge Capital Partners, LP
4.3%
INTEGRATED CORE STRATEGIES (US) LLC
0.6%
Ownership % is shown only when SEC disclosures are safely comparable across share classes.
Detailed SEC evidence table Showing 1-8 of 50 holder rows
| Holder | Evidence | Ownership % | Position | 12M Net Δ | As of |
|---|---|---|---|---|---|
| RTW INVESTMENTS, LP |
3/4/5
13D/G
13F
10%+ Owner · Company
|
9.9%
from 13D/G
|
$28,360,648
3,256,102 shares
|
— | 22 Mar 2023 |
| Propel Bio Management, LLC |
13D/G
13F
Company
|
9.9%
|
$21,001,011
8,861,186 shares
|
$0 | 11 Jul 2025 |
| Adage Capital Management, L.P. |
13D/G
|
6.4%
|
$16,000,000
8,000,000 shares
|
-$1,318,128 | 31 Mar 2026 |
| Trails Edge Capital Partners, LP |
13D/G
|
4.3%
|
$9,013,333
5,333,333 shares
|
-$6,226,884 | 20 Mar 2026 |
| INTEGRATED CORE STRATEGIES (US) LLC |
13D/G
|
0.6%
|
$396,161
322,082 shares
|
$0 | 31 Mar 2025 |
| TWO SIGMA INVESTMENTS, LP |
13F
Company
|
1.9%
|
$2,757,439
2,317,176 shares
|
— | 31 Mar 2026 |
| GOLDMAN SACHS GROUP INC |
13F
Company
|
1.6%
|
$2,380,030
2,000,025 shares
|
— | 31 Mar 2026 |
| MARSHALL WACE, LLP |
13F
Company
|
1.6%
|
$2,313,991
1,944,530 shares
|
— | 31 Mar 2026 |
How to read this table
Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
Forms 3/4/5 flow
Insider trading overview
Net insider flow leans to selling over the last 12 months. Net value: -$1,176,157.
Buys
$0
Insiders: 0
Sells
$1,176,157
Insiders: 5
Net
-$1,176,157
Shares: -523,079
Window
Last 12 months
4 rolling buckets
Buy value
Sell value
Shares: 0
Shares: 523,079
| Window (months) | Buy shares | Sell shares | Buy value | Sell value | Net value |
|---|---|---|---|---|---|
| 0-3 | 0 | 0 | $0 | $0 | $0 |
| 3-6 | 0 | 36,500 | $0 | $82,490 | -$82,490 |
| 6-9 | 0 | 486,579 | $0 | $1,093,667 | -$1,093,667 |
| 9-12 | 0 | 0 | $0 | $0 | $0 |
Reporting owners
Insider holders from Forms 3/4/5
Showing 1-17 of 17 reporting-owner rows connected to Milestone Pharmaceuticals Inc.. Open a relationship link for the CIK-to-CIK filing trail.
Rows
17
Largest Forms 3/4/5 holder
RTW INVESTMENTS, LP
Net 12M change
-$1,176,158
Latest report
10 Jun 2026
| Name | Relationship | Holdings Value | Past Year Net Change | Change % | Valuation | Report Date |
|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 10%+ Owner | $28,360,648 | Mixed | 22 Mar 2023 | ||
| Joseph Oliveto | President and CEO, Director | $1,008,511 | -$555,680 | -36% | Filing P/S | 16 Apr 2026 |
| Lorenz Muller | Chief Commercial Officer | $396,433 | -$145,851 | -27% | Filing P/S | 02 Feb 2026 |
| Paul F. Truex | Director | $383,548 | Mixed | 31 May 2022 | ||
| David Bharucha | Chief Medical Officer | $218,439 | -$158,209 | -42% | Filing P/S | 02 Feb 2026 |
| Amit Hasija | CFO & EVP of Corp. Development | $192,706 | -$158,209 | -45% | Filing P/S | 02 Feb 2026 |
| Joseph C. Papa | Director | $137,000 | Mixed | 10 Jun 2026 | ||
| Jeffrey Edward Nelson | Chief Operating Officer | $96,206 | -$158,209 | -62% | Filing P/S | 02 Feb 2026 |
| Robert James Wills | Director | $89,050 | Mixed | 10 Jun 2026 | ||
| Debra K. Liebert | Director | $42,186 | Mixed | 11 Jul 2025 | ||
| David I. Sandoval | GC & Chief Compliance Officer | Mixed | 17 Mar 2026 | |||
| Stuart Duty | Director | Mixed | 10 Jun 2026 | |||
| Andrew Saik | Director | Mixed | 10 Jun 2026 | |||
| Seth H. Z. Fischer | Director | Mixed | 10 Jun 2026 | |||
| Richard C. Pasternak | Director | Mixed | 07 Jun 2023 | |||
| Michael John Tomsicek | Director | Mixed | 10 Jun 2026 | |||
| Lisa M. Giles | Director | Mixed | 10 Jun 2026 |
Recent insider transactions for Milestone Pharmaceuticals Inc.
Showing up to 300 recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | SEC-reported value | SEC-reported price | Shares | Shares owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Lisa M. Giles | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Seth H. Z. Fischer | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Stuart Duty | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Robert James Wills | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Michael John Tomsicek | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Andrew Saik | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Joseph C. Papa | MIST | Stock Option (right to buy) | Award | 77,000 | 77,000 | 10 Jun 2026 | Direct | |||
| Joseph Oliveto | MIST | Common Shares | Sale | -7.56% | $82,490 | $2.26 | -36,500 | 446,244 | 16 Apr 2026 | Direct |
| Jeffrey Edward Nelson | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| David Bharucha | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| Amit Hasija | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| Lorenz Muller | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| Joseph Oliveto | MIST | Employee Stock Option (right to buy) | Award | 679,000 | 679,000 | 02 Feb 2026 | Direct | |||
| Jeffrey Edward Nelson | MIST | Common Shares | Sale | -19.7% | $23,633 | $1.93 | -12,245 | 49,848 | 26 Jan 2026 | Direct |
| Jeffrey Edward Nelson | MIST | Common Shares | Options Exercise | 47.9% | 20,100 | 62,093 | 26 Jan 2026 | Direct | ||
| Jeffrey Edward Nelson | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| David Bharucha | MIST | Common Shares | Sale | -9.76% | $23,633 | $1.93 | -12,245 | 113,181 | 26 Jan 2026 | Direct |
| David Bharucha | MIST | Common Shares | Options Exercise | 19.1% | 20,100 | 125,426 | 26 Jan 2026 | Direct | ||
| David Bharucha | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| Amit Hasija | MIST | Common Shares | Sale | -10.9% | $23,633 | $1.93 | -12,245 | 99,848 | 26 Jan 2026 | Direct |
| Amit Hasija | MIST | Common Shares | Options Exercise | 21.8% | 20,100 | 112,093 | 26 Jan 2026 | Direct | ||
| Amit Hasija | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| Lorenz Muller | MIST | Common Shares | Sale | -5.16% | $21,577 | $1.93 | -11,180 | 205,406 | 26 Jan 2026 | Direct |
| Lorenz Muller | MIST | Common Shares | Options Exercise | 10.2% | 20,100 | 216,586 | 26 Jan 2026 | Direct | ||
| Lorenz Muller | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| Joseph Oliveto | MIST | Common Shares | Sale | -6.67% | $66,629 | $1.93 | -34,523 | 482,744 | 26 Jan 2026 | Direct |
| Joseph Oliveto | MIST | Common Shares | Options Exercise | 14.8% | 66,600 | 517,267 | 26 Jan 2026 | Direct | ||
| Joseph Oliveto | MIST | Restricted Stock Units | Options Exercise | -25% | -66,600 | 199,800 | 26 Jan 2026 | Direct | ||
| Joseph Oliveto | MIST | Common Shares | Sale | -12.4% | $96,750 | $2.25 | -43,000 | 303,721 | 08 Jan 2026 | Direct |
| Joseph Oliveto | MIST | Common Shares | Sale | -0.14% | $1,125 | $2.25 | -500 | 346,721 | 07 Jan 2026 | Direct |
| Jeffrey Edward Nelson | MIST | Common Shares | Sale | -58% | $134,576 | $2.32 | -58,007 | 41,993 | 15 Dec 2025 | Direct |
| David Bharucha | MIST | Common Shares | Sale | -35.5% | $134,576 | $2.32 | -58,007 | 105,326 | 15 Dec 2025 | Direct |
| Amit Hasija | MIST | Common Shares | Sale | -38.7% | $134,576 | $2.32 | -58,007 | 91,993 | 15 Dec 2025 | Direct |
| Lorenz Muller | MIST | Common Shares | Sale | -21.4% | $124,273 | $2.32 | -53,566 | 196,486 | 15 Dec 2025 | Direct |
| Joseph Oliveto | MIST | Common Shares | Sale | -22.8% | $308,685 | $2.32 | -133,054 | 450,667 | 15 Dec 2025 | Direct |
| Jeffrey Edward Nelson | MIST | Common Shares | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Jeffrey Edward Nelson | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| David Bharucha | MIST | Common Shares | Award | 157.9% | 100,000 | 163,333 | 12 Dec 2025 | Direct | ||
| David Bharucha | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Amit Hasija | MIST | Common Shares | Award | 200% | 100,000 | 150,000 | 12 Dec 2025 | Direct | ||
| Amit Hasija | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Lorenz Muller | MIST | Common Shares | Award | 66.6% | 100,000 | 250,052 | 12 Dec 2025 | Direct | ||
| Lorenz Muller | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Joseph Oliveto | MIST | Common Shares | Award | 92.2% | 280,000 | 583,721 | 12 Dec 2025 | Direct | ||
| Joseph Oliveto | MIST | Employee Stock Option (right to buy) | Award | 280,000 | 280,000 | 12 Dec 2025 | Direct | |||
| Lorenz Muller | MIST | Common Shares | Gift | -14.3% | -25,000 | 150,052 | 09 Dec 2025 | Direct |
* marks a reported price that did not pass the local price check.