Key facts
- MIST - Milestone Pharmaceuticals Inc. has 17 insiders with reported activity on this page.
- Net insider value flow over the last year: -$1,176,157.
- Recent transaction rows are available for direct filing-level review.
Insider Transactions Reported by 17 Insiders of Milestone Pharmaceuticals Inc.
- Symbol
- MIST on Nasdaq
- Location
- Montreal, Quebec, Canada
Change
- Buy value: ; sell value: $1,176,157.
- Net share flow: -523,079.
Research use
- This page gives a plain-language issuer insider context before you inspect transaction-level evidence.
- Use the filing links below to verify timestamps, codes, and ownership impacts directly from SEC forms.
Evidence
Filed on Form 4
See Original Filing
Issuer insider activity is sourced from SEC Forms 3, 4, and 5.
Insider trading overview
Last 12 monthsNet insider flow leans to selling over the last 12 months. Net value: -$1,176,157.
Buys
$0
Shares: 0
Insiders: 0
Sells
$1,176,157
Shares: 523,079
Insiders: 5
Net
-$1,176,157
Shares: -523,079
Insiders: -5
| Window (months) | Buy shares | Sell shares | Buy $ | Sell $ | Net $ |
|---|---|---|---|---|---|
| 0-3 | 0 | 36,500 | $0 | $82,490 | -$82,490 |
| 3-6 | 0 | 486,579 | $0 | $1,093,667 | -$1,093,667 |
| 6-9 | 0 | 0 | $0 | $0 | $0 |
| 9-12 | 0 | 0 | $0 | $0 | $0 |
Milestone Pharmaceuticals Inc. executives and other stock owners filed with the SEC include:
| Name | Relationship | Holdings Value | Past Year Net Change | Change % | Valuation | Report Date |
|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 10%+ Owner | $28,360,648 | Mixed | 22 Mar 2023 | ||
| Joseph Oliveto | President and CEO, Director | $1,008,511 | -$555,680 | -36% | Filing P/S | 16 Apr 2026 |
| Lorenz Muller | Chief Commercial Officer | $396,433 | -$145,851 | -27% | Filing P/S | 02 Feb 2026 |
| Paul F. Truex | Director | $383,548 | Mixed | 31 May 2022 | ||
| David Bharucha | Chief Medical Officer | $218,439 | -$158,209 | -42% | Filing P/S | 02 Feb 2026 |
| Amit Hasija | CFO & EVP of Corp. Development | $192,706 | -$158,209 | -45% | Filing P/S | 02 Feb 2026 |
| Joseph C. Papa | Director | $137,000 | Mixed | 11 Jul 2025 | ||
| Jeffrey Edward Nelson | Chief Operating Officer | $96,206 | -$158,209 | -62% | Filing P/S | 02 Feb 2026 |
| Robert James Wills | Director | $89,050 | Mixed | 11 Jul 2025 | ||
| Debra K. Liebert | Director | $42,186 | Mixed | 11 Jul 2025 | ||
| David I. Sandoval | GC & Chief Compliance Officer | Mixed | 17 Mar 2026 | |||
| Stuart Duty | Director | Mixed | 10 Jun 2025 | |||
| Andrew Saik | Director | Mixed | 10 Jun 2025 | |||
| Seth H. Z. Fischer | Director | Mixed | 10 Jun 2025 | |||
| Michael John Tomsicek | Director | Mixed | 10 Jun 2025 | |||
| Lisa M. Giles | Director | Mixed | 10 Jun 2025 | |||
| Richard C. Pasternak | Director | Mixed | 07 Jun 2023 |
Top shareholders of Milestone Pharmaceuticals Inc. (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP |
3/4/5
13D/G
13F
|
10%+ Owner · Company |
9.9%
from 13D/G
|
3,256,102
|
$28,360,648 | — | 22 Mar 2023 | |
| Propel Bio Management, LLC |
13D/G
13F
|
Company |
9.9%
|
8,861,186
|
$21,001,011 | $0 | 11 Jul 2025 | |
| Adage Capital Management, L.P. |
13D/G
|
— |
6.4%
|
8,000,000
|
$16,000,000 | -$1,318,128 | 31 Mar 2026 | |
| Trails Edge Capital Partners, LP |
13D/G
|
— |
4.3%
|
5,333,333
|
$9,013,333 | -$6,226,884 | 20 Mar 2026 | |
| INTEGRATED CORE STRATEGIES (US) LLC |
13D/G
|
— |
0.6%
|
322,082
|
$396,161 | $0 | 31 Mar 2025 | |
| TWO SIGMA INVESTMENTS, LP |
13F
|
Company |
1.9%
|
2,317,176
|
$2,757,439 | — | 31 Mar 2026 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
1.6%
|
2,000,025
|
$2,380,030 | — | 31 Mar 2026 | |
| MARSHALL WACE, LLP |
13F
|
Company |
1.6%
|
1,944,530
|
$2,313,991 | — | 31 Mar 2026 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
1.2%
|
1,544,325
|
$1,837,747 | — | 31 Mar 2026 | |
| Simplify Asset Management Inc. |
13F
|
Company |
1.2%
|
1,506,405
|
$1,792,622 | — | 31 Mar 2026 | |
| Point72 Asset Management, L.P. |
13F
|
Company |
0.87%
|
1,085,683
|
$1,291,963 | — | 31 Mar 2026 | |
| BALYASNY ASSET MANAGEMENT L.P. |
13F
|
Company |
0.68%
|
851,325
|
$1,013,077 | — | 31 Mar 2026 | |
| Lion Point Capital, LP |
13F
|
Company |
0.66%
|
820,000
|
$975,800 | — | 31 Mar 2026 | |
| TORONTO DOMINION BANK |
13F
|
Company |
0.6%
|
750,000
|
$892,500 | — | 31 Mar 2026 | |
| MORGAN STANLEY |
13F
|
Company |
0.58%
|
724,141
|
$861,727 | — | 31 Mar 2026 | |
| Boxer Capital Management, LLC |
13F
|
Company |
0.53%
|
666,666
|
$793,333 | — | 31 Mar 2026 | |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
13F
|
Company |
0.42%
|
519,046
|
$617,665 | — | 31 Mar 2026 | |
| UBS Group AG |
13F
|
Company |
0.4%
|
494,908
|
$588,940 | — | 31 Mar 2026 | |
| Squarepoint Ops LLC |
13F
|
Company |
0.27%
|
336,825
|
$400,822 | — | 31 Mar 2026 | |
| Seven Fleet Capital Management LP |
13F
|
Company |
0.27%
|
333,333
|
$396,666 | — | 31 Mar 2026 | |
| Aptus Capital Advisors, LLC |
13F
|
Company |
0.22%
|
280,250
|
$333,498 | — | 31 Mar 2026 | |
| GUARDIAN WEALTH ADVISORS, LLC / NC |
13F
|
Company |
0.22%
|
280,250
|
$333,498 | — | 31 Mar 2026 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.16%
|
196,696
|
$234,068 | — | 31 Mar 2026 | |
| LPL Financial LLC |
13F
|
Company |
0.15%
|
193,373
|
$230,114 | — | 31 Mar 2026 | |
| BNP PARIBAS FINANCIAL MARKETS |
13F
|
Company |
0.14%
|
176,504
|
$210,040 | — | 31 Mar 2026 | |
| BOOTHBAY FUND MANAGEMENT, LLC |
13F
|
Company |
0.14%
|
168,675
|
$200,723 | — | 31 Mar 2026 | |
| JANE STREET GROUP, LLC |
13F
|
Company |
0.13%
|
159,669
|
$190,006 | — | 31 Mar 2026 | |
| SIMPLEX TRADING, LLC |
13F
|
Company |
0.12%
|
149,291
|
$177,656 | — | 31 Mar 2026 | |
| Quadrature Capital Ltd |
13F
|
Company |
0.12%
|
149,105
|
$177,435 | — | 31 Mar 2026 | |
| Valeo Financial Advisors, LLC |
13F
|
Company |
0.1%
|
130,699
|
$155,532 | — | 31 Mar 2026 | |
| GROUP ONE TRADING LLC |
13F
|
Company |
0.1%
|
129,764
|
$154,419 | — | 31 Mar 2026 | |
| RENAISSANCE TECHNOLOGIES LLC |
13F
|
Company |
0.1%
|
129,705
|
$154,349 | — | 31 Mar 2026 | |
| XTX Topco Ltd |
13F
|
Company |
0.1%
|
120,602
|
$143,516 | — | 31 Mar 2026 | |
| ADAR1 Capital Management, LLC |
13F
|
Company |
0.08%
|
100,000
|
$119,000 | — | 31 Mar 2026 | |
| TRU INDEPENDENCE ASSET MANAGEMENT 2, LLC |
13F
|
Company |
0.08%
|
100,000
|
$119,000 | — | 31 Mar 2026 | |
| HRT FINANCIAL LP |
13F
|
Company |
0.05%
|
62,256
|
$74,000 | — | 31 Mar 2026 | |
| Cambridge Investment Research Advisors, Inc. |
13F
|
Company |
0.05%
|
59,620
|
$71,000 | — | 31 Mar 2026 | |
| October Effect Ltd |
13F
|
Company |
0.04%
|
51,950
|
$61,821 | — | 31 Mar 2026 | |
| SG Americas Securities, LLC |
13F
|
Company |
0.03%
|
42,512
|
$51,000 | — | 31 Mar 2026 | |
| Invesco Ltd. |
13F
|
Company |
0.03%
|
41,356
|
$49,214 | — | 31 Mar 2026 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
0.03%
|
40,789
|
$48,538 | — | 31 Mar 2026 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.03%
|
38,779
|
$46,147 | — | 31 Mar 2026 | |
| Focus Partners Wealth |
13F
|
Company |
0.03%
|
36,000
|
$42,840 | — | 31 Mar 2026 | |
| Mariner, LLC |
13F
|
Company |
0.02%
|
30,830
|
$36,688 | — | 31 Mar 2026 | |
| Bay Rivers Group |
13F
|
Company |
0.02%
|
29,911
|
$35,594 | — | 31 Mar 2026 | |
| Federation Des Caisses Desjardins du Quebec |
13F
|
Individual |
0.02%
|
29,781
|
$35,439 | — | 31 Mar 2026 | |
| GSA CAPITAL PARTNERS LLP |
13F
|
Company |
0.02%
|
26,893
|
$32,000 | — | 31 Mar 2026 | |
| RAYMOND JAMES FINANCIAL INC |
13F
|
Company |
0.02%
|
26,600
|
$31,654 | — | 31 Mar 2026 | |
| Safeguard Investment Advisory Group, LLC |
13F
|
Company |
0.02%
|
25,044
|
$29,802 | — | 31 Mar 2026 | |
| WELCH & FORBES LLC |
13F
|
Company |
0.02%
|
25,000
|
$29,750 | — | 31 Mar 2026 |
Recent Insider Transactions by Companies or Individuals for Milestone Pharmaceuticals Inc.
Showing up to 300 most recent insider transactions from the last 12 months.
| Insider | Symbol | Class | Transaction | % | Value $ | * Price $ | Shares | Shares Owned | Date | Ownership |
|---|---|---|---|---|---|---|---|---|---|---|
| Joseph Oliveto | MIST | Common Shares | Sale | -7.56% | $82,490 | $2.26 | -36,500 | 446,244 | 16 Apr 2026 | Direct |
| Jeffrey Edward Nelson | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| David Bharucha | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| Amit Hasija | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| Lorenz Muller | MIST | Employee Stock Option (right to buy) | Award | 204,000 | 204,000 | 02 Feb 2026 | Direct | |||
| Joseph Oliveto | MIST | Employee Stock Option (right to buy) | Award | 679,000 | 679,000 | 02 Feb 2026 | Direct | |||
| Jeffrey Edward Nelson | MIST | Common Shares | Sale | -19.7% | $23,633 | $1.93 | -12,245 | 49,848 | 26 Jan 2026 | Direct |
| Jeffrey Edward Nelson | MIST | Common Shares | Options Exercise | 47.9% | 20,100 | 62,093 | 26 Jan 2026 | Direct | ||
| Jeffrey Edward Nelson | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| David Bharucha | MIST | Common Shares | Sale | -9.76% | $23,633 | $1.93 | -12,245 | 113,181 | 26 Jan 2026 | Direct |
| David Bharucha | MIST | Common Shares | Options Exercise | 19.1% | 20,100 | 125,426 | 26 Jan 2026 | Direct | ||
| David Bharucha | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| Amit Hasija | MIST | Common Shares | Sale | -10.9% | $23,633 | $1.93 | -12,245 | 99,848 | 26 Jan 2026 | Direct |
| Amit Hasija | MIST | Common Shares | Options Exercise | 21.8% | 20,100 | 112,093 | 26 Jan 2026 | Direct | ||
| Amit Hasija | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| Lorenz Muller | MIST | Common Shares | Sale | -5.16% | $21,577 | $1.93 | -11,180 | 205,406 | 26 Jan 2026 | Direct |
| Lorenz Muller | MIST | Common Shares | Options Exercise | 10.2% | 20,100 | 216,586 | 26 Jan 2026 | Direct | ||
| Lorenz Muller | MIST | Restricted Stock Units | Options Exercise | -25% | -20,100 | 60,300 | 26 Jan 2026 | Direct | ||
| Joseph Oliveto | MIST | Common Shares | Sale | -6.67% | $66,629 | $1.93 | -34,523 | 482,744 | 26 Jan 2026 | Direct |
| Joseph Oliveto | MIST | Common Shares | Options Exercise | 14.8% | 66,600 | 517,267 | 26 Jan 2026 | Direct | ||
| Joseph Oliveto | MIST | Restricted Stock Units | Options Exercise | -25% | -66,600 | 199,800 | 26 Jan 2026 | Direct | ||
| Joseph Oliveto | MIST | Common Shares | Sale | -12.4% | $96,750 | $2.25 | -43,000 | 303,721 | 08 Jan 2026 | Direct |
| Joseph Oliveto | MIST | Common Shares | Sale | -0.14% | $1,125 | $2.25 | -500 | 346,721 | 07 Jan 2026 | Direct |
| Jeffrey Edward Nelson | MIST | Common Shares | Sale | -58% | $134,576 | $2.32 | -58,007 | 41,993 | 15 Dec 2025 | Direct |
| David Bharucha | MIST | Common Shares | Sale | -35.5% | $134,576 | $2.32 | -58,007 | 105,326 | 15 Dec 2025 | Direct |
| Amit Hasija | MIST | Common Shares | Sale | -38.7% | $134,576 | $2.32 | -58,007 | 91,993 | 15 Dec 2025 | Direct |
| Lorenz Muller | MIST | Common Shares | Sale | -21.4% | $124,273 | $2.32 | -53,566 | 196,486 | 15 Dec 2025 | Direct |
| Joseph Oliveto | MIST | Common Shares | Sale | -22.8% | $308,685 | $2.32 | -133,054 | 450,667 | 15 Dec 2025 | Direct |
| Jeffrey Edward Nelson | MIST | Common Shares | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Jeffrey Edward Nelson | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| David Bharucha | MIST | Common Shares | Award | 157.9% | 100,000 | 163,333 | 12 Dec 2025 | Direct | ||
| David Bharucha | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Amit Hasija | MIST | Common Shares | Award | 200% | 100,000 | 150,000 | 12 Dec 2025 | Direct | ||
| Amit Hasija | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Lorenz Muller | MIST | Common Shares | Award | 66.6% | 100,000 | 250,052 | 12 Dec 2025 | Direct | ||
| Lorenz Muller | MIST | Employee Stock Option (right to buy) | Award | 100,000 | 100,000 | 12 Dec 2025 | Direct | |||
| Joseph Oliveto | MIST | Common Shares | Award | 92.2% | 280,000 | 583,721 | 12 Dec 2025 | Direct | ||
| Joseph Oliveto | MIST | Employee Stock Option (right to buy) | Award | 280,000 | 280,000 | 12 Dec 2025 | Direct | |||
| Lorenz Muller | MIST | Common Shares | Gift | -14.3% | -25,000 | 150,052 | 09 Dec 2025 | Direct | ||
| Debra K. Liebert | MIST | Common Shares | Award | 13122.8% | 16,666 | 16,793 | 11 Jul 2025 | Direct | ||
| Debra K. Liebert | MIST | Series B Common Warrants (right to buy) | Award | 16,793 | 16,793 | 11 Jul 2025 | Direct | |||
| Debra K. Liebert | MIST | Series A Common Warrants (right to buy) | Award | 16,793 | 16,793 | 11 Jul 2025 | Direct | |||
| Amit Hasija | MIST | Common Shares | Award | 50,000 | 50,000 | 11 Jul 2025 | Direct | |||
| Amit Hasija | MIST | Series B Common Warrants (right to buy) | Award | 50,000 | 50,000 | 11 Jul 2025 | Direct | |||
| Amit Hasija | MIST | Series A Common Warrants (right to buy) | Award | 50,000 | 50,000 | 11 Jul 2025 | Direct | |||
| Robert James Wills | MIST | Common Shares | Award | 333.3% | 50,000 | 65,000 | 11 Jul 2025 | Direct | ||
| Robert James Wills | MIST | Series B Common Warrants (right to buy) | Award | 50,000 | 50,000 | 11 Jul 2025 | Direct | |||
| Robert James Wills | MIST | Series A Common Warrants (right to buy) | Award | 50,000 | 50,000 | 11 Jul 2025 | Direct | |||
| David Bharucha | MIST | Common Shares | Award | 533.3% | 53,333 | 63,333 | 11 Jul 2025 | Direct | ||
| David Bharucha | MIST | Series B Common Warrants (right to buy) | Award | 53,333 | 53,333 | 11 Jul 2025 | Direct |
* An asterisk sign (*) next to the price indicates that the price is likely invalid.