Milestone Pharmaceuticals Inc. - Common Stock (MIST) Institutional Ownership

13F Institutional Holders and Ownership History from Q2 2019 to Q4 2025

Type / Class
Equity / Common Stock
Symbol
MIST on Nasdaq
Shares outstanding
89,506,929
Price per share
$2.02
All holders as of 30 Sep 2025
Q3 2025
Total 13F shares
34,138,461
Total reported value
$68,276,752
% of total 13F portfolios
0%
Share change
+22,320,755
Value change
+$44,826,873
Number of holders
61
Price from insider filings
$2.02
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Milestone Pharmaceuticals Inc. - Common Stock (MIST) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
RTW INVESTMENTS, LP 9.9% -0.9% $18,310,336 +$7,029,150 9,155,168 +62% RTW Investments, LP 30 Sep 2025
Trails Edge Capital Partners, LP 9.9% 0% $18,035,760 +$339,996 9,017,880 +1.9% Trails Edge Capital Partners, LP 30 Sep 2025
Propel Bio Management, LLC 9.9% $21,001,011 8,861,186 Propel Bio Management, LLC 11 Jul 2025
Adage Capital Management, L.P. 10% $17,318,128 8,659,064 Adage Capital Management, L.P. 30 Sep 2025
INTEGRATED CORE STRATEGIES (US) LLC 0.6% $396,161 322,082 Integrated Core Strategies (US) LLC 31 Mar 2025

As of 30 Sep 2025, 61 institutional investors reported holding 34,138,461 shares of Milestone Pharmaceuticals Inc. - Common Stock (MIST). This represents 38% of the company’s total 89,506,929 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Milestone Pharmaceuticals Inc. - Common Stock (MIST) together control 37% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
ADAGE CAPITAL PARTNERS GP, L.L.C. 7.8% 6,976,000 0.02% $13,952,000
Propel Bio Management, LLC 5.7% 5,124,890 +186% 10% $10,249,780
ORBIMED ADVISORS LLC 3.6% 3,221,828 0.15% $6,443,656
MORGAN STANLEY 3.3% 2,969,067 +262% 0% $5,938,134
Simplify Asset Management Inc. 3.2% 2,832,974 +186% 0.11% $5,665,948
RTW INVESTMENTS, LP 2.8% 2,506,102 0% 0.06% $5,012,204
Pathstone Holdings, LLC 1.1% 1,000,000 0.01% $2,000,000
SPHERA FUNDS MANAGEMENT LTD. 0.92% 820,000 0.39% $1,640,000
TORONTO DOMINION BANK 0.84% 750,000 0% 0% $1,500,000
Affinity Asset Advisors, LLC 0.74% 666,666 0.12% $1,333,332
Boxer Capital Management, LLC 0.74% 666,666 0.42% $1,333,332
TWO SIGMA INVESTMENTS, LP 0.74% 666,551 0% $1,333,102
Lion Point Capital, LP 0.74% 658,553 +20% 7.5% $1,317,106
CITADEL ADVISORS LLC 0.57% 512,067 0% $1,024,134
MARSHALL WACE, LLP 0.47% 425,028 0% $850,056
JANE STREET GROUP, LLC 0.46% 408,492 +1179% 0% $816,984
MILLENNIUM MANAGEMENT LLC 0.45% 401,559 0% $803,118
UBS Group AG 0.44% 397,534 +23% 0% $795,068
GOLDMAN SACHS GROUP INC 0.4% 356,567 +199% 0% $713,134
SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.29% 256,772 +305% 0% $513,544
TWO SIGMA ADVISERS, LP 0.26% 234,041 0% $468,082
AMH Equity Ltd 0.26% 231,671 0.58% $463,342
Quadrature Capital Ltd 0.25% 223,470 0.01% $448,057
Aptus Capital Advisors, LLC 0.23% 210,200 0% $420,400
GUARDIAN WEALTH ADVISORS, LLC / NC 0.23% 210,200 0.03% $420,400

Institutional Holders of Milestone Pharmaceuticals Inc. - Common Stock (MIST) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 126,536 $255,905 +$222,189 $2.02 3
2025 Q3 34,138,461 $68,276,752 +$44,826,873 $2.00 61
2025 Q2 11,817,806 $22,925,663 +$893,027 $1.94 43
2025 Q1 11,824,370 $9,461,152 -$26,033,743 $0.80 43
2024 Q4 24,552,580 $57,943,143 -$9,780,800 $2.36 46
2024 Q3 28,677,385 $43,589,418 -$2,288,268 $1.52 41
2024 Q2 30,178,631 $39,890,373 -$1,767,212 $1.32 39
2024 Q1 31,068,273 $55,610,121 +$23,911,141 $1.79 40
2023 Q4 17,804,637 $29,733,304 -$3,789,133 $1.67 40
2023 Q3 19,572,198 $60,672,803 -$3,310,719 $3.10 39
2023 Q2 20,687,365 $58,958,957 -$3,141,348 $2.85 48
2023 Q1 21,710,779 $85,540,237 -$9,705,873 $3.94 49
2022 Q4 23,737,827 $94,006,246 -$28,853,317 $3.96 55
2022 Q3 20,398,285 $187,452,026 +$10,127,011 $9.19 43
2022 Q2 20,825,690 $127,165,640 -$2,809,102 $6.15 29
2022 Q1 21,048,124 $135,124,913 +$5,027,454 $6.42 28
2021 Q4 20,243,658 $132,596,706 +$1,818,999 $6.55 27
2021 Q3 19,956,009 $113,947,594 -$1,093,248 $5.71 26
2021 Q2 20,148,798 $110,818,750 -$885,245 $5.50 26
2021 Q1 20,284,874 $117,447,374 -$1,995,259 $5.79 31
2020 Q4 20,571,334 $137,829,226 +$33,967,631 $6.70 33
2020 Q3 15,483,607 $113,344,014 +$42,783,062 $7.32 29
2020 Q2 9,754,497 $36,871,064 +$2,941,736 $3.78 23
2020 Q1 9,242,998 $17,005,883 -$32,694,365 $1.84 16
2019 Q4 14,399,976 $230,543,150 +$20,592,614 $16.01 25
2019 Q3 13,069,709 $239,626,222 -$2,837,983 $18.65 23
2019 Q2 13,080,914 $350,497,172 +$350,497,172 $27.15 25