| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Opaleye Management, Inc. | 4.8% | 4.11M | 0 | 4.11M | /s/ James Silverman | President | |
| Opaleye, L.P. | 4.8% | 4.11M | 0 | 4.11M | /s/ James Silverman | General Partner | |
| James Silverman | 4.8% | 4.11M | 0 | 4.11M | /s/ James Silverman | Individually |