RTW INVESTMENTS, LP - 31 Dec 2025 SCHEDULE 13G/A Report for TAYSHA GENE THERAPIES, INC. Common Stock, par value $0.00001 per share (TSHA)

Filing Manager: RTW INVESTMENTS, LP
Reporting Manager: RTW Investments, LP
Security: TAYSHA GENE THERAPIES, INC. Common Stock, par value $0.00001 per share
Symbol: TSHA
Shares outstanding: 282,013,651 shares
Disclosed Ownership: 23,407,133 shares
Ownership: 8.3%
Form type: SCHEDULE 13G/A
Filing time: 17 Feb 2026, 08:49:15 UTC
Date of event: 31 Dec 2025
Previous filing: 14 Aug 2025
SEC: View on sec.gov

Reporting Managers (2)

Name	Ownership	Shares Owned	sole voting power	shared voting power	Signature	Title	CIK
RTW Investments, LP	8.3%	23,407,133	0	23,407,133	/s/ Roderick Wong, M.D.	Roderick Wong, M.D., Managing Partner
Roderick Wong	8.3%	23,407,133	0	23,407,133	s/ Roderick Wong, M.D.	Roderick Wong, M.D.