| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Opaleye Management Inc. | 11% | 2,388,638 | 0 | 2,388,638 | /s/ James Silverman | President | |
| Opaleye, L.P. | 11% | 2,308,638 | 0 | 2,308,638 | /s/ James Silverman | General Partner | |
| James Silverman | 11% | 2,388,638 | 0 | 2,388,638 | /s/ James Silverman | Individually |