| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 11% | 17,122,563 | 0 | 17,122,563 | Kristin Mariani | Head of North America Compliance, CCO | |
| Janus Henderson Biotech Innovation Master Fund Ltd | 10% | 15,589,805 | 0 | 15,589,805 | Kristin Mariani | Head of North America Compliance, CCO |