| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| Northpond Ventures, LP | 6.9% | $136M | 54.5M | Michael P. Rubin | Jun 4, 2025 | |||
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.62% | $114M | 43.6M | Adage Capital Management, L.P. | Dec 31, 2024 | |||
| MANGROVE PARTNERS IM, LLC | 4.9% | $80.2M | 39M | Mangrove Partners IM, LLC | Sep 30, 2025 | |||
| Rock Springs Capital Management LP | 4.2% | $87.2M | 33.4M | Rock Springs Capital Management LP | Mar 31, 2025 | |||
| Frazier Life Sciences Public Fund, L.P. | 4.1% | -20% | $52.2M | -$12.7M | 32.4M | -19.6% | Frazier Life Sciences Public Fund, L.P. | Jun 30, 2025 |
| JANUS HENDERSON GROUP PLC | 10.2% | -8.18% | $33.6M | -$2.88M | 16.3M | -7.91% | JANUS HENDERSON GROUP PLC | Sep 30, 2025 |
| Adage Capital Management, L.P. | 1.07% | $22.2M | 8.5M | Adage Capital Management, L.P. | Mar 31, 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 99.5M | $205M | -$1.64M | $2.06 | 82 |
| 2025 Q2 | 98.6M | $268M | -$28.7M | $2.71 | 85 |
| 2025 Q1 | 111M | $250M | -$12.6M | $2.25 | 87 |
| 2024 Q4 | 115M | $403M | +$29.7M | $3.50 | 90 |
| 2024 Q3 | 106M | $435M | +$21.8M | $4.11 | 76 |
| 2024 Q2 | 101M | $362M | +$59.8M | $3.60 | 76 |
| 2024 Q1 | 84M | $277M | +$19.4M | $3.30 | 77 |
| 2023 Q4 | 78.5M | $181M | +$20.4M | $2.31 | 61 |
| 2023 Q3 | 69.9M | $90.2M | +$9.89M | $1.29 | 52 |
| 2023 Q2 | 63.6M | $84M | +$9.81M | $1.32 | 49 |
| 2023 Q1 | 60.8M | $43M | -$604K | $0.71 | 56 |
| 2022 Q4 | 61.4M | $46.1M | -$7.74M | $0.75 | 57 |
| 2022 Q3 | 68M | $58.5M | -$7.13M | $0.86 | 56 |
| 2022 Q2 | 73.6M | $82.5M | -$16.9M | $1.12 | 58 |
| 2022 Q1 | 88.9M | $99.6M | -$3.07M | $1.12 | 55 |
| 2021 Q4 | 90.9M | $145M | -$12.2M | $1.60 | 67 |
| 2021 Q3 | 87.5M | $212M | -$26.7M | $2.42 | 58 |
| 2021 Q2 | 89.6M | $284M | -$2.19M | $3.17 | 68 |
| 2021 Q1 | 90.2M | $304M | +$111M | $3.37 | 65 |
| 2020 Q4 | 57.1M | $205M | +$139M | $3.58 | 44 |
| 2020 Q3 | 14.3M | $38.1M | +$18.6M | $2.62 | 22 |
| 2020 Q2 | 7.28M | $22.3M | +$12.6M | $3.06 | 20 |
| 2020 Q1 | 3.28M | $3.42M | +$2.08M | $1.04 | 8 |
| 2019 Q4 | 1.24M | $4.08M | -$2.39M | $3.28 | 10 |
| 2019 Q3 | 1.78M | $5.21M | -$42.9K | $2.98 | 14 |
| 2019 Q2 | 1.8M | $4.38M | +$4.38M | $2.52 | 15 |