| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Perceptive Advisors LLC | 11.5% | 6,485,420 | 0 | 6,485,420 | /s/ Joseph Edelman | Joseph Edelman, Managing Member | 0001224962 |
| Joseph Edelman | 11.5% | 6,485,420 | 0 | 6,485,420 | /s/ Joseph Edelman | Joseph Edelman | 0001164426 |
| Perceptive Life Sciences Master Fund, Ltd. | 8.6% | 4,873,721 | 0 | 4,873,721 | /s/ Joseph Edelman | By: Perceptive Advisors LLC, By: Joseph Edelman, Managing Member | 0001249675 |
| Perceptive Xontogeny Venture Fund, L.P. | 2.9% | 1,611,699 | 0 | 1,611,699 | /s/ Joseph Edelman | By: Perceptive Xontogeny Ventures GP, LLC; By: Joseph Edelman, Managing Member | 0001757940 |