| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| Perceptive Advisors LLC | 10% | 12,594,211 | 0 | 12,594,211 | /s/ Joseph Edelman | Joseph Edelman, Managing Member | 0001224962 |
| Joseph Edelman | 10% | 12,594,211 | 0 | 12,594,211 | /s/ Joseph Edelman | Joseph Edelman | 0001164426 |
| Perceptive Life Sciences Master Fund, Ltd. | 9.9% | 12,428,351 | 0 | 12,428,351 | /s/ Joseph Edelman | By Perceptive Advisors LLC, by Joseph Edelman, Managing Member | 0001249675 |