| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 10.7% | 6.65M | 0 | 6.65M | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VII LLC | 10.7% | 6.65M | 0 | 6.65M | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001760648 |