| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 12% | 7.4M | 0 | 7.4M | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VII LLC | 12% | 7.4M | 0 | 7.4M | /s/ Carl L. Gordon | Carl L. Gordon/Member of the Managing Member | 0001760648 |
| ORBIMED CAPITAL LLC | 0% | 0 | 0 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001157524 |