| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 9.5% | 5.92M | 0 | 5.92M | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VII LLC | 9.5% | 5.92M | 0 | 5.92M | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC | 0001760648 |