| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| Zanganeh Mahkam | Co-Chief Executive Officer, Director, 10%+ Owner | C/O SUMMIT THERAPEUTICS INC., 601 BRICKELL KEY DRIVE, SUITE 1000, MIAMI | /s/ Mahkam Zanganeh | 2025-10-23 | 0001507650 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | SMMT | Common Stock | Award | $5M | +267K | +1.05% | $18.74 | 25.7M | Oct 21, 2025 | By the Mahkam Zanganeh Revocable Trust, with the Reporting Person as Trustee | F1, F2 |
| transaction | SMMT | Common Stock | Purchase | $500K | +26.7K | +53.36% | $18.74 | 76.7K | Oct 21, 2025 | Immediate family member | F1, F2 |
| transaction | SMMT | Common Stock | Award | $262M | +14M | +2.51% | $18.74 | 570M | Oct 21, 2025 | By Spouse | F1, F2 |
| holding | SMMT | Common Stock | 10.2M | Oct 21, 2025 | By the Shaun Zanganeh Irrevocable Trust, with the Reporting Person as Trustee | F2 | |||||
| holding | SMMT | Common Stock | 31K | Oct 21, 2025 | Direct |
| Id | Content |
|---|---|
| F1 | Acquired in a private placement transaction pursuant to the terms of a definitive agreement, dated as of October 21, 2025, pursuant to which the Issuer agreed to sell shares of common stock to the Reporting Person and certain other parties at a purchase price of $18.74 per share. The transaction is anticipated to close on or about October 23, 2025. |
| F2 | The Reporting Person disclaims beneficial ownership of these securities, except to the extent of her pecuniary interest therein, if any, and the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 or for any other purpose. |