Mahkam Zanganeh - 02 Jan 2026 Form 4 Insider Report for Summit Therapeutics Inc. (SMMT)

Role: Co-Chief Executive Officer, Director, 10%+ Owner
Signature: /s/ Mahkam Zanganeh
Issuer symbol: SMMT
Transactions as of: 02 Jan 2026
Net transactions value: +$98,392
Form type: 4
Filing time: 06 Jan 2026, 19:52:54 UTC
Previous filing: 23 Oct 2025
SEC: View on sec.gov

Reporting Owners (1)

Name	Relationship	Address	Signature	Signature date	CIK
Zanganeh Mahkam	Co-Chief Executive Officer, Director, 10%+ Owner	C/O SUMMIT THERAPEUTICS INC., 601 BRICKELL KEY DRIVE, SUITE 1000, MIAMI	/s/ Mahkam Zanganeh	06 Jan 2026	0001507650

Derivative Securities (e.g., puts, calls, warrants, options, convertible securities)

Type	Sym	Class	Transaction	Value $	Shares	Change %	* Price $	Shares After	Date	Underlying Class	Amount	Exercise Price	Ownership	Footnotes
transaction	SMMT	Stock Option (right to buy)	Award	$98,392	+11,232		$8.76	11,232	02 Jan 2026	Common Stock	11,232	$17.52	By Spouse	F1, F2, F3

* An asterisk sign (*) next to the price indicates that the price is likely invalid.

Explanation of Responses:

Id	Content
F1	The option was granted on January 2, 2026. The shares underlying the option shall vest in four quarterly installments on March 31, June 30, September 30 and December 31 following election, subject to the reporting person's spouse remaining as a non-salaried director on each such vesting date.
F2	The option was issued to the reporting person's spouse pursuant to the issuer's Director Retainer Option Election Plan in lieu of retainer fees of $98,400.
F3	The reporting person disclaims beneficial ownership of these securities, except to the extent of her pecuniary interest therein, if any, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all the reported shares for purposes of Section 16 or any other purpose.