| Name | Relationship | Address | Signature | Signature date | CIK |
|---|---|---|---|---|---|
| HENDERSON MICHAEL THOMAS | Chief Executive Officer, Director | C/O APOGEE THERAPEUTICS, INC., 221 CRESCENT ST., BLDG. 17, STE. 102B, WALTHAM | /s/ Matthew Batters, as attorney-in-fact for Michael Henderson | 16 Jan 2026 | 0001779990 |
| Type | Sym | Class | Transaction | Value $ | Shares | Change % | * Price $ | Shares After | Date | Ownership | Footnotes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| transaction | APGE | Common Stock | Sale | $113,242 | -1,440 | -0.12% | $78.64 | 1,211,547 | 14 Jan 2026 | Direct | F1, F2 |
| transaction | APGE | Common Stock | Sale | $676,554 | -8,476 | -0.7% | $79.82 | 1,203,071 | 14 Jan 2026 | Direct | F1, F3 |
| transaction | APGE | Common Stock | Sale | $192,294 | -2,374 | -0.2% | $81.00 | 1,200,697 | 14 Jan 2026 | Direct | F1, F4 |
| transaction | APGE | Common Stock | Sale | $152,788 | -1,854 | -0.15% | $82.41 | 1,198,843 | 14 Jan 2026 | Direct | F1, F5 |
| transaction | APGE | Common Stock | Sale | $447,900 | -5,386 | -0.45% | $83.16 | 1,193,457 | 14 Jan 2026 | Direct | F1, F6 |
| transaction | APGE | Common Stock | Sale | $39,381 | -470 | -0.04% | $83.79 | 1,192,987 | 14 Jan 2026 | Direct | F1, F7 |
Buy Plan / Sale Plan: These are also open market purchases/sales of shares, but in this case the transaction is part of a trading plan. Rule 10b5-1 allows insiders to setup a trading plan to buy/sell stocks over a certain period of time. Since the purchases/sales are predetermined, this protects the insiders from violating insider trading law.
Transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c).
| Id | Content |
|---|---|
| F1 | This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on August 13, 2025. |
| F2 | The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $78.16 to $79.10, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range. |
| F3 | The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $79.28 to $80.02, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. |
| F4 | The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $80.69 to $81.55, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. |
| F5 | The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $81.70 to $82.69, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. |
| F6 | The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $82.71 to $83.68, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. |
| F7 | The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $83.73 to $83.84, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. |