Opaleye Management Inc.

Holdings History for KARYOPHARM THERAPEUTICS INC - NOTE 3.000%10/1

Investment type: Debt / NOTE 3.000%10/1

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Principal	Change	Activity %	Price	All Holders
31 Dec 2025		-0.65%	$0	0	-6,000,000	-100%		Q4 2025
30 Sep 2025	0.65%	0%	$4,630,842	6,000,000	0		77.18%	Q3 2025
30 Jun 2025	0.92%	0%	$4,556,052	6,000,000	0		75.93%	Q2 2025
31 Mar 2025	1%	0%	$4,556,892	6,000,000	0		75.95%	Q1 2025
31 Dec 2024	0.82%	0%	$4,669,560	6,000,000	0		77.83%	Q4 2024
30 Sep 2024	0.66%	0%	$3,960,672	6,000,000	0		66.01%	Q3 2024
30 Jun 2024	0.86%	+0.82%	$3,747,156	6,000,000	+6,000,000	NEW	62.45%	Q2 2024

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.