TWO SIGMA INVESTMENTS, LP

Holdings History for Prime Medicine, Inc. - COMMON STOCK (PRME)

Symbol: PRME on Nasdaq
Investment type: Equity / COMMON STOCK

Shares, Excluding Options vs Price

Value, Excluding Options

Holdings date	Weight	Change	Value $	Shares	Change	Activity %	Price	All Holders
31 Dec 2025	0.01%	+0.01%	$5,653,754	1,629,324	+1,181,657	+264%	$3.47	Q4 2025
30 Sep 2025	0%	+0%	$2,480,075	447,667	+189,244	+73%	$5.54	Q3 2025
30 Jun 2025	0%	-0%	$638,305	258,423	-347	-0.13%	$2.47	Q2 2025
31 Mar 2025	0%	+0%	$514,952	258,770	+92,571		$1.99	Q1 2025
31 Dec 2024	0%	-0%	$485,301	166,199	-152,374	-48%	$2.92	Q4 2024
30 Sep 2024	0%	-0%	$1,232,878	318,573	-362,903	-53%	$3.87	Q3 2024
30 Jun 2024	0.01%	+0%	$3,502,787	681,476	+173,398	+34%	$5.14	Q2 2024
31 Mar 2024	0.01%	+0%	$3,556,546	508,078	+239,716	+89%	$7.00	Q1 2024
31 Dec 2023	0.01%	+0%	$2,377,687	268,362	+175,369	+189%	$8.86	Q4 2023
30 Sep 2023	0%	+0%	$887,153	92,993	+92,993	NEW	$9.54	Q3 2023

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.