| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| ARCH Venture Fund XII, L.P. | 10% | $80,853,607 | 18,587,036 | Robert Nelsen | 07 Aug 2025 | |||
| GV 2019, L.P. | 12% | $91,756,239 | 16,562,498 | Alphabet Holdings LLC | 30 Sep 2025 | |||
| FMR LLC | 3.8% | $37,294,150 | 6,731,796 | FMR LLC | 30 Sep 2025 | |||
| Newpath Partners, L.P. | 4.7% | $9,769,086 | 6,105,679 | Newpath Partners, L.P. | 31 Dec 2024 | |||
| T. Rowe Price Investment Management, Inc. | 3.3% | -40% | $25,659,383 | -$13,874,784 | 5,995,183 | -35% | T. Rowe Price Investment Management, Inc. | 31 Dec 2025 |
As of 31 Dec 2025, 179 institutional investors reported holding 96,944,932 shares of Prime Medicine, Inc. - COMMON STOCK (PRME). This represents 53% of the company’s total 181,672,212 outstanding shares.
The largest institutional shareholders of Prime Medicine, Inc. - COMMON STOCK (PRME) together control 47% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| Alphabet Inc. | 9.1% | 16,562,498 | 0% | 2.2% | $57,471,868 |
| BlackRock, Inc. | 4.6% | 8,268,843 | +46% | 0% | $28,692,886 |
| VANGUARD GROUP INC | 3.6% | 6,467,872 | +31% | 0% | $22,443,516 |
| T. Rowe Price Investment Management, Inc. | 3.3% | 5,995,183 | -35% | 0.01% | $20,804,000 |
| ARK Investment Management LLC | 3% | 5,368,526 | -2% | 0.12% | $18,628,784 |
| STATE STREET CORP | 2.8% | 5,095,510 | +293% | 0% | $17,681,420 |
| Amova Asset Management Americas, Inc. | 1.8% | 3,245,506 | -11% | 0.13% | $11,196,996 |
| Sumitomo Mitsui Trust Group, Inc. | 1.8% | 3,245,506 | -11% | 0.01% | $11,261,906 |
| Casdin Capital, LLC | 1.7% | 3,167,175 | 0% | 0.68% | $10,990,097 |
| Balyasny Asset Management L.P. | 1.7% | 3,124,362 | +6426% | 0.02% | $10,841,536 |
| Woodline Partners LP | 1.7% | 3,002,844 | +0.01% | 0.04% | $10,419,869 |
| GEODE CAPITAL MANAGEMENT, LLC | 1.4% | 2,628,429 | +49% | 0% | $9,123,032 |
| UBS Group AG | 1.3% | 2,440,583 | +701% | 0% | $8,468,823 |
| FMR LLC | 1.2% | 2,176,646 | -23% | 0% | $7,552,961 |
| MWG Caph Ltd | 0.99% | 1,792,210 | 0% | 8.6% | $6,218,969 |
| GOLDMAN SACHS GROUP INC | 0.97% | 1,755,768 | +327% | 0% | $6,092,515 |
| TWO SIGMA INVESTMENTS, LP | 0.9% | 1,629,324 | +264% | 0.01% | $5,653,754 |
| D. E. Shaw & Co., Inc. | 0.85% | 1,551,369 | -30% | 0% | $5,383,250 |
| FARALLON CAPITAL MANAGEMENT LLC | 0.68% | 1,240,843 | -74% | 0.02% | $4,305,725 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0.65% | 1,176,727 | +101% | 0.01% | $4,083,243 |
| MORGAN STANLEY | 0.64% | 1,169,898 | +60% | 0% | $4,059,547 |
| RENAISSANCE TECHNOLOGIES LLC | 0.63% | 1,149,159 | +1.3% | 0.01% | $3,987,582 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.52% | 936,815 | +63% | 0% | $3,250,748 |
| NORTHERN TRUST CORP | 0.46% | 842,153 | +39% | 0% | $2,922,271 |
| Greenwich Wealth Management LLC | 0.41% | 740,001 | +2.8% | 0.11% | $2,568,000 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2025 Q4 | 96,944,932 | $336,340,963 | +$437,407 | $3.47 | 179 |
| 2025 Q3 | 92,362,985 | $511,620,997 | +$186,859,815 | $5.54 | 166 |
| 2025 Q2 | 58,654,950 | $144,864,309 | -$2,708,584 | $2.47 | 118 |
| 2025 Q1 | 60,327,480 | $120,048,763 | -$9,144,075 | $1.99 | 121 |
| 2024 Q4 | 64,302,617 | $187,767,212 | -$16,411,951 | $2.92 | 128 |
| 2024 Q3 | 68,711,037 | $265,862,243 | -$1,687,770 | $3.87 | 113 |
| 2024 Q2 | 68,888,470 | $353,995,003 | +$8,574,594 | $5.14 | 119 |
| 2024 Q1 | 66,659,039 | $466,578,147 | +$125,445,462 | $7.00 | 112 |
| 2023 Q4 | 48,691,116 | $431,437,073 | -$10,408,984 | $8.86 | 102 |
| 2023 Q3 | 49,517,421 | $472,282,828 | +$28,502,950 | $9.54 | 82 |
| 2023 Q2 | 46,131,758 | $675,732,293 | +$67,078,075 | $14.65 | 77 |
| 2023 Q1 | 41,738,575 | $512,085,492 | +$2,897,210 | $12.30 | 73 |
| 2022 Q4 | 41,322,385 | $767,784,036 | +$767,085,261 | $18.58 | 65 |