Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME)
CUSIP: 98985Y108
Q4 2025 13F Holders as of 31 Dec 2025
- Type / Class
- Equity / Common Stock, $0.00001 par value per share
- Shares outstanding
- 73,603,315
- Total 13F shares
- 71,441,303
- Share change
- -2,172,328
- Total reported value
- $1,881,059,421
- Put/Call ratio
- 38%
- Price per share
- $26.33
- Number of holders
- 205
- Value change
- -$32,229,794
- Number of buys
- 112
- Number of sells
- 80
Quarterly Holders Quick Answers
What is CUSIP 98985Y108?
CUSIP 98985Y108 identifies ZYME - Zymeworks Inc. - Common Stock, $0.00001 par value per share in SEC institutional holdings data.
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Recent filing periods for CUSIP 98985Y108:
Top shareholders of ZYME - Zymeworks Inc. - Common Stock, $0.00001 par value per share (13F + 13D/G + 3/4/5)
Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.
Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.
| Holder | Source | Role / Reporting | Ownership % | Shares | Holdings Value | 12M Net Δ | As of | Details |
|---|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC |
13D/G
3/4/5
13F
|
Director, 10%+ Owner · Company |
31%
|
22,970,388
|
$420,817,508 | $0 | 16 Nov 2025 | |
| Oleg Nodelman |
3/4/5
|
Director, 10%+ Owner |
—
class O/S missing
|
15,720,161
|
$218,112,518 | — | 17 Feb 2025 | |
| Rubric Capital Management LP |
13D/G
13F
|
Company |
7.7%
|
5,750,000
|
$153,065,000 | $0 | 31 Dec 2025 | |
| BlackRock, Inc. |
13F
13D/G
|
Company |
4.8%
from 13D/G
|
3,989,533
|
$68,141,224 | — | 30 Sep 2025 | |
| MORGAN STANLEY |
13F
13D/G
|
Company |
3.4%
from 13D/G
|
3,984,585
|
$68,056,714 | — | 30 Sep 2025 | |
| BIOTECHNOLOGY VALUE FUND L P |
13D/G
|
BVF PARTNERS L P/IL |
5.2%
|
3,938,641
|
$67,271,988 | $0 | 30 Sep 2025 | |
| BVF INC/IL |
13F
|
Company |
5.4%
|
3,938,641
|
$67,271,988 | — | 30 Sep 2025 | |
| Redmile Group, LLC |
13D/G
3/4/5
13F
|
10%+ Owner · Company |
4.9%
|
3,705,750
|
$63,294,210 | -$7,598,499 | 30 Sep 2025 | |
| VANGUARD GROUP INC |
13F
|
Company |
2.9%
|
2,154,434
|
$36,797,732 | — | 30 Sep 2025 | |
| PERCEPTIVE ADVISORS LLC |
13F
|
Company |
2.8%
|
2,090,663
|
$35,708,524 | — | 30 Sep 2025 | |
| Vestal Point Capital, LP |
13F
|
Company |
2.4%
|
1,765,000
|
$30,146,200 | — | 30 Sep 2025 | |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
13F
|
Company |
2.3%
|
1,710,463
|
$29,214,708 | — | 30 Sep 2025 | |
| Blackstone Inc. |
13F
|
Company |
2.2%
|
1,616,290
|
$27,606,233 | — | 30 Sep 2025 | |
| DEUTSCHE BANK AG\ |
13F
|
Company |
2.1%
|
1,544,898
|
$26,386,859 | — | 30 Sep 2025 | |
| Assenagon Asset Management S.A. |
13F
|
Company |
1.8%
|
1,326,774
|
$22,661,300 | — | 30 Sep 2025 | |
| DIMENSIONAL FUND ADVISORS LP |
13F
|
Company |
1.6%
|
1,190,838
|
$20,340,605 | — | 30 Sep 2025 | |
| Nextech Invest, Ltd. |
13F
|
Company |
1.5%
|
1,113,946
|
$19,026,198 | — | 30 Sep 2025 | |
| MILLENNIUM MANAGEMENT LLC |
13F
|
Company |
1.5%
|
1,104,813
|
$18,870,206 | — | 30 Sep 2025 | |
| TANG CAPITAL MANAGEMENT LLC |
13F
|
Company |
1.5%
|
1,100,000
|
$18,788,000 | — | 30 Sep 2025 | |
| STATE STREET CORP |
13F
|
Company |
1.5%
|
1,081,189
|
$18,466,708 | — | 30 Sep 2025 | |
| Prosight Management, LP |
13F
|
Company |
1%
|
749,611
|
$12,803,356 | — | 30 Sep 2025 | |
| GEODE CAPITAL MANAGEMENT, LLC |
13F
|
Company |
0.92%
|
678,636
|
$11,590,695 | — | 30 Sep 2025 | |
| Nuveen, LLC |
13F
|
Company |
0.77%
|
565,385
|
$9,656,776 | — | 30 Sep 2025 | |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
13F
|
Company |
0.77%
|
564,000
|
$9,633,120 | — | 30 Sep 2025 | |
| GOLDMAN SACHS GROUP INC |
13F
|
Company |
0.6%
|
443,525
|
$7,575,407 | — | 30 Sep 2025 | |
| RENAISSANCE TECHNOLOGIES LLC |
13F
|
Company |
0.59%
|
431,700
|
$7,373,436 | — | 30 Sep 2025 | |
| JUPITER ASSET MANAGEMENT LTD |
13F
|
Company |
0.48%
|
350,660
|
$5,989,273 | — | 30 Sep 2025 | |
| NORTHERN TRUST CORP |
13F
|
Company |
0.47%
|
348,253
|
$5,948,161 | — | 30 Sep 2025 | |
| Granahan Investment Management, LLC |
13F
|
Company |
0.47%
|
345,331
|
$5,898,253 | — | 30 Sep 2025 | |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
13F
|
Company |
0.43%
|
313,753
|
$5,358,901 | — | 30 Sep 2025 | |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
13F
|
Company |
0.37%
|
272,797
|
$4,659,373 | — | 30 Sep 2025 | |
| Qube Research & Technologies Ltd |
13F
|
Company |
0.35%
|
255,002
|
$4,355,434 | — | 30 Sep 2025 | |
| Squarepoint Ops LLC |
13F
|
Company |
0.3%
|
219,948
|
$3,756,712 | — | 30 Sep 2025 | |
| Hillsdale Investment Management Inc. |
13F
|
Company |
0.29%
|
216,422
|
$3,696,488 | — | 30 Sep 2025 | |
| ALGERT GLOBAL LLC |
13F
|
Company |
0.28%
|
207,926
|
$3,551,000 | — | 30 Sep 2025 | |
| Samsara BioCapital, LLC |
13F
|
Company |
0.28%
|
207,901
|
$3,550,949 | — | 30 Sep 2025 | |
| CITADEL ADVISORS LLC |
13F
|
Company |
0.28%
|
206,858
|
$3,533,135 | — | 30 Sep 2025 | |
| PICTON MAHONEY ASSET MANAGEMENT |
13F
|
Company |
0.28%
|
206,322
|
$3,524,000 | — | 30 Sep 2025 | |
| BARCLAYS PLC |
13F
|
Company |
0.27%
|
199,023
|
$3,399,312 | — | 30 Sep 2025 | |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13F
|
Company |
0.26%
|
193,360
|
$3,302,589 | — | 30 Sep 2025 | |
| FEDERATED HERMES, INC. |
13F
|
Company |
0.25%
|
182,847
|
$3,123,027 | — | 30 Sep 2025 | |
| WELLS FARGO & COMPANY/MN |
13F
|
Company |
0.24%
|
176,634
|
$3,016,902 | — | 30 Sep 2025 | |
| WELLINGTON MANAGEMENT GROUP LLP |
13F
|
Company |
0.23%
|
168,685
|
$2,881,140 | — | 30 Sep 2025 | |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
13F
|
Company |
0.22%
|
161,486
|
$2,782,404 | — | 30 Sep 2025 | |
| Man Group plc |
13F
|
Company |
0.22%
|
158,616
|
$2,709,161 | — | 30 Sep 2025 | |
| AXA Investment Managers S.A. |
13F
|
Company |
0.22%
|
158,416
|
$2,705,745 | — | 30 Sep 2025 | |
| MARSHALL WACE, LLP |
13F
|
Company |
0.21%
|
154,858
|
$2,644,975 | — | 30 Sep 2025 | |
| AQR CAPITAL MANAGEMENT LLC |
13F
|
Company |
0.21%
|
152,632
|
$2,606,954 | — | 30 Sep 2025 | |
| KENNEDY CAPITAL MANAGEMENT LLC |
13F
|
Company |
0.2%
|
146,440
|
$2,501,195 | — | 30 Sep 2025 | |
| JANE STREET GROUP, LLC |
13F
|
Company |
0.2%
|
145,206
|
$2,480,119 | — | 30 Sep 2025 |
Institutional Holders of Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) as of Q4 2025
As of 31 Dec 2025,
Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME) was held by
205 institutional
shareholders
that filed Form 13F with the SEC.
Together, they reported ownership of
71,441,303 shares.
The largest 10 holders included
EcoR1 Capital, LLC, Rubric Capital Management LP, BlackRock, Inc., BVF INC/IL, PERCEPTIVE ADVISORS LLC, MORGAN STANLEY, VANGUARD GROUP INC, BNP PARIBAS ASSET MANAGEMENT Holding S.A., Siren, L.L.C., and DEUTSCHE BANK AG\.
This page lists
205
institutional shareholders reporting positions in this security
for the Q4 2025 filing period.
| Investor | Option | Weight % | Change % | Value $ | * Price | Shares | Share Change | Activity | Report Period |
|---|
Compare Q4 2025 vs Q3 2025 Across Filers
Q3 2025 holders
181
Q4 2025 holders
205
Holder diff
24
| Investor | Q3 2025 Shares | Q4 2025 Shares | Share Diff | Share Chg % | Q3 2025 Value $ | Q4 2025 Value $ | Value Diff $ | Value Chg % |
|---|
Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).
Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.
An asterisk sign (*) next to the price indicates that the price is likely invalid.