Zymeworks Inc. - Common Stock, $0.00001 par value per share (ZYME)

CUSIP: 98985Y108

Q4 2025 13F Holders as of 31 Dec 2025

Security type / class
Equity / Common Stock, $0.00001 par value per share
Total 13F shares
71,450,392
Total 13F value
$1,881,298,833
Holder snapshot 6 visible 7 signals
Share change
-2,172,328
Put/Call ratio
38%
SEC-reported price per share
$26.33
Number of holders
208
Value change
-$32,229,794
Number of buys
112
Open additional details 1 more signal available
Number of sells
80
Security identity Names, identifiers, and filing context for this profile. 1 source field
Shares outstanding
73,761,855

Security key

98985Y108

Report period

Q4 2025

Institutions

208

Top holders

10

ZYME full security history Ownership snapshot Full 13F holder table Newer quarter: Q1 2026 Previous quarter: Q3 2025 Zymeworks Inc. SEC filings Zymeworks Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Ownership snapshot

Top reported holders of ZYME - Zymeworks Inc. - Common Stock, $0.00001 par value per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader
EcoR1 Capital, LLC
Disclosed value leader
EcoR1 Capital, LLC
Comparable rows
15/15
Latest evidence
16 Nov 2025
13D/G 3/4/5 13F Lead comparable stake: 31% 13D/G row: EcoR1 Capital, LLC Showing 1-6 of 15 holder rows.

Quick read

EcoR1 Capital, LLC leads the comparable SEC ownership view at 31%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens EcoR1 Capital, LLC's linked filing trail.
Comparable ownership Top 5
EcoR1 Capital, LLC 31%
BIOTECHNOLOGY VALUE FUND L P 5.2%
Redmile Group, LLC 4.9%
BlackRock, Inc. 4.8%
MORGAN STANLEY 3.4%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows
Holder Evidence Ownership % Position 12M Net Δ As of
EcoR1 Capital, LLC
13D/G 3/4/5 13F
Director, 10%+ Owner · Company
13D/G 3/4/5 13F
31%
$420,817,508
22,970,388 shares
 $0 16 Nov 2025
BIOTECHNOLOGY VALUE FUND L P
13D/G
BVF PARTNERS L P/IL
13D/G
5.2%
$67,271,988
3,938,641 shares
 $0 30 Sep 2025
Redmile Group, LLC
13D/G 3/4/5 13F
10%+ Owner · Company
13D/G 3/4/5 13F
4.9%
$63,294,210
3,705,750 shares
 -$7,598,499 30 Sep 2025
BlackRock, Inc.
13F 13D/G
Company
13F 13D/G
4.8%
from 13D/G
$68,141,224
3,989,533 shares
 — 30 Sep 2025
MORGAN STANLEY
13F 13D/G
Company
13F 13D/G
3.4%
from 13D/G
$68,056,714
3,984,585 shares
 — 30 Sep 2025
Rubric Capital Management LP
13F
Company
13F
6.4%
$80,456,211
4,710,551 shares
 — 30 Sep 2025
How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q4 2025

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions
208
Shares
71,450,392
Rows available
208
Investor Option Weight % Change % SEC-reported value * Price Shares Share Change Activity Report Period

* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q4 2025 vs Q3 2025 Across Filers

Q3 2025 holders
181
Q4 2025 holders
208
Holder diff
27
Investor Q3 2025 Shares Q4 2025 Shares Share Diff Share Chg % Q3 2025 value Q4 2025 value Value change Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
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