| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 13.8% | -6.67% | $570M | -$33.8M | 8.58M | -5.6% | BlackRock, Inc. | 30 Sep 2025 |
| Farallon Capital Partners, L.P. | 9.99% | $265M | 5.96M | Dapice Joshua J. | 31 Dec 2024 | |||
| STATE STREET CORP | 5.2% | +20% | $170M | $26.6M | 3.21M | +18.5% | STATE STREET CORPORATION | 30 Jun 2025 |
| BIOTECHNOLOGY VALUE FUND L P | 4.1% | -22% | $170M | -$43.2M | 2.56M | -20.2% | BVF PARTNERS L P/IL | 30 Sep 2025 |
| Deep Track Capital, LP | 2.76% | -50.6% | $114M | -$102M | 1.72M | -47.2% | Deep Track Capital, LP | 30 Sep 2025 |
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Change | Price | Investors |
|---|---|---|---|---|---|
| 2025 Q3 | 70.7M | $4.7B | +$3.94M | $66.43 | 272 |
| 2025 Q2 | 71M | $3.92B | +$345M | $55.27 | 273 |
| 2025 Q1 | 65M | $3.14B | +$116M | $48.36 | 273 |
| 2024 Q4 | 63.3M | $2.44B | +$44.2M | $38.60 | 240 |
| 2024 Q3 | 61.6M | $2.77B | -$40.5M | $45.00 | 238 |
| 2024 Q2 | 59.1M | $2.05B | -$15.1M | $34.65 | 187 |
| 2024 Q1 | 59.7M | $1.73B | +$80.4M | $28.93 | 183 |
| 2023 Q4 | 57.5M | $1.32B | +$12.2M | $22.93 | 155 |
| 2023 Q3 | 56.7M | $946M | -$53.3M | $16.68 | 142 |
| 2023 Q2 | 56.7M | $1.57B | +$105M | $27.62 | 163 |
| 2023 Q1 | 53.2M | $1.22B | +$180M | $23.00 | 135 |
| 2022 Q4 | 49M | $535M | +$12.4M | $10.91 | 135 |
| 2022 Q3 | 47.3M | $399M | -$50.1M | $8.43 | 129 |
| 2022 Q2 | 53.4M | $422M | -$73.7M | $7.91 | 125 |
| 2022 Q1 | 50.3M | $1.19B | -$6.17M | $23.68 | 136 |
| 2021 Q4 | 49.2M | $1.68B | +$93.5M | $34.20 | 144 |
| 2021 Q3 | 46.2M | $819M | -$247M | $17.72 | 126 |
| 2021 Q2 | 48M | $2.15B | +$180M | $44.88 | 136 |
| 2021 Q1 | 44.2M | $1.14B | +$27.8M | $25.90 | 124 |
| 2020 Q4 | 43M | $867M | +$98.8M | $20.16 | 124 |
| 2020 Q3 | 37.2M | $727M | +$62.1M | $19.55 | 91 |
| 2020 Q2 | 34M | $601M | +$210M | $17.66 | 82 |
| 2020 Q1 | 23.4M | $165M | +$1.23M | $7.06 | 75 |
| 2019 Q4 | 23.2M | $164M | +$7.87M | $7.05 | 79 |
| 2019 Q3 | 18.9M | $228M | +$20.6M | $12.01 | 74 |
| 2019 Q2 | 17.2M | $208M | +$26M | $12.11 | 66 |
| 2019 Q1 | 15.1M | $189M | +$21.7M | $12.57 | 64 |
| 2018 Q4 | 13.9M | $93.2M | -$9.99M | $6.73 | 62 |
| 2018 Q3 | 16M | $165M | +$26.8M | $10.29 | 60 |
| 2018 Q2 | 13.9M | $93.6M | +$10.9M | $6.72 | 68 |
| 2018 Q1 | 11.9M | $103M | -$12M | $8.59 | 67 |
| 2017 Q4 | 11.8M | $246M | +$77.2M | $20.80 | 64 |
| 2017 Q3 | 8.13M | $144M | +$619K | $17.67 | 41 |
| 2017 Q2 | 8.12M | $91.8M | -$277K | $11.31 | 40 |
| 2017 Q1 | 8.01M | $103M | +$4.47M | $12.81 | 39 |
| 2016 Q4 | 7.98M | $175M | +$2.37M | $21.99 | 38 |
| 2016 Q3 | 6.9M | $145M | +$145M | $21.13 | 34 |