Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share (ORKA)

Q: What does CUSIP 687604108 represent in this 13F holders report?

CUSIP 687604108 is the security identifier for ORKA - Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share used to aggregate holder disclosures.

Q: How many institutions held ORKA - Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share in Q4 2025?

143 institutional investors reported ORKA - Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share for Q4 2025. Use the holders table for investor-level position and value details.

CUSIP: 687604108

Q4 2025 13F Holders as of 31 Dec 2025

Type / Class: Equity / Common Stock, $0.001 par value per share
Shares outstanding: 50,314,906
Total 13F shares: 52,853,940
Share change: +5,589,327
Total reported value: $1,602,043,688
Put/Call ratio: 85%
Price per share: $30.31
Number of holders: 143
Value change: +$170,793,609
Number of buys: 93
Number of sells: 24

Quarterly Holders Quick Answers

What is CUSIP 687604108?
CUSIP 687604108 identifies ORKA - Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share in SEC institutional holdings data.

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Explore More Reporting Periods

Jump to adjacent filing periods for faster comparison and easier crawl discovery.

Newer quarter: Q1 2026
Previous quarter: Q3 2025

Recent filing periods for CUSIP 687604108:

Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024

Top shareholders of ORKA - Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked by the holder's primary source value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
FMR LLC	13F	Company	14%	7,257,621	$139,564,052	—	30 Sep 2025	13F
BlackRock, Inc.	13D/G 13F	Company	6.6%	3,175,483	$96,248,890	+$29,642,149	31 Dec 2025	13D/G 13F
Venrock Healthcare Capital Partners III, L.P.	13D/G 3/4/5	10%+ Owner	9.9%	4,909,619	$94,411,973	+$14,637,703	30 Sep 2025	13D/G 3/4/5
VR Adviser, LLC	13F	Company	8.2%	4,148,428	$79,774,270	—	30 Sep 2025	13F
Fairmount Funds Management LLC	13F 3/4/5	Company · Director, 10%+ Owner	7.4%	3,705,262	$71,252,188	—	30 Sep 2025	13F 3/4/5
Deep Track Capital, LP	13D/G 13F	Company	4.5%	2,161,510	$65,515,368	+$8,023,966	31 Dec 2025	13D/G 13F
RTW INVESTMENTS, LP	13D/G 13F	Company	4.3%	2,058,148	$62,382,466	+$3,409,845	31 Dec 2025	13D/G 13F
VIKING GLOBAL INVESTORS LP	13F	Company	5.3%	2,666,690	$51,280,449	—	30 Sep 2025	13F
VANGUARD GROUP INC	13F	Company	3.5%	1,776,665	$34,165,268	—	30 Sep 2025	13F
Commodore Capital LP	13F	Company	3.5%	1,753,054	$33,711,228	—	30 Sep 2025	13F
BRAIDWELL LP	13F	Company	2.7%	1,382,350	$26,582,591	—	30 Sep 2025	13F
Avoro Capital Advisors LLC	13F	Company	2.6%	1,333,340	$25,640,128	—	30 Sep 2025	13F
PERCEPTIVE ADVISORS LLC	13F	Company	2.5%	1,268,021	$24,384,044	—	30 Sep 2025	13F
Funicular Funds, LP	3/4/5	Other*, 10%+ Owner	— mixed-class rows	9,179,356 mixed-class rows	$22,903,390	—	15 Dec 2022	3/4/5
FRANKLIN RESOURCES INC	13F	Company	2.1%	1,065,782	$20,494,988	—	30 Sep 2025	13F
Point72 Asset Management, L.P.	13F	Company	2.1%	1,037,002	$19,941,548	—	30 Sep 2025	13F
Polar Capital Holdings Plc	13F	Company	2.1%	1,032,307	$19,851,264	—	30 Sep 2025	13F
Affinity Asset Advisors, LLC	13F	Company	1.9%	959,180	$18,445,031	—	30 Sep 2025	13F
MERCER GLOBAL ADVISORS INC /ADV	13F	Company	1.7%	852,411	$16,391,864	—	30 Sep 2025	13F
Blackstone Inc.	13F	Company	1.7%	850,400	$16,353,192	—	30 Sep 2025	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	1.4%	689,972	$13,271,325	—	30 Sep 2025	13F
Avidity Partners Management LP	13F	Company	1.3%	660,424	$12,699,954	—	30 Sep 2025	13F
STATE STREET CORP	13F	Company	1.3%	652,028	$12,538,498	—	30 Sep 2025	13F
PRICE T ROWE ASSOCIATES INC /MD/	13F	Company	1.2%	626,806	$12,054,000	—	30 Sep 2025	13F
Woodline Partners LP	13F	Company	1.1%	574,330	$11,044,366	—	30 Sep 2025	13F
Cormorant Asset Management, LP	13F	Company	1.1%	533,340	$10,256,128	—	30 Sep 2025	13F
Cable Car Capital, LP	13F	Company	0.99%	500,000	$9,615,000	—	30 Sep 2025	13F
SR ONE CAPITAL MANAGEMENT, LP	13F	Company	0.86%	430,330	$8,275,246	—	30 Sep 2025	13F
S.c.a. Candriam	13F	Individual	0.73%	366,994	$7,057,295	—	30 Sep 2025	13F
Funicular Fund, LP	3/4/5	Other*	— mixed-class rows	2,594,952 mixed-class rows	$6,451,130	—	23 May 2022	3/4/5
JANUS HENDERSON GROUP PLC	3/4/5	10%+ Owner	— class O/S missing	2,117,213	$6,302,520	—	16 Aug 2024	3/4/5
CITADEL ADVISORS LLC	13F	Company	0.63%	316,886	$6,093,717	—	30 Sep 2025	13F
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	13F	Company	0.49%	246,926	$4,748,387	—	30 Sep 2025	13F
NORTHERN TRUST CORP	13F	Company	0.44%	219,709	$4,225,004	—	30 Sep 2025	13F
GREAT POINT PARTNERS LLC	13F	Company	0.36%	183,330	$3,525,436	—	30 Sep 2025	13F
MORGAN STANLEY	13F	Company	0.27%	134,833	$2,592,838	—	30 Sep 2025	13F
D. E. Shaw & Co., Inc.	13F	Company	0.19%	95,417	$1,834,869	—	30 Sep 2025	13F
BARCLAYS PLC	13F	Company	0.19%	95,330	$1,833,196	—	30 Sep 2025	13F
WELLINGTON MANAGEMENT GROUP LLP	13F	Company	0.18%	91,094	$1,751,737	—	30 Sep 2025	13F
UBS Group AG	13F	Company	0.17%	86,560	$1,664,549	—	30 Sep 2025	13F
BANK OF AMERICA CORP /DE/	13F	Company	0.16%	78,995	$1,519,074	—	30 Sep 2025	13F
Aberdeen Group plc	13F	Company	0.15%	75,680	$1,455,326	—	30 Sep 2025	13F
B Group, Inc.	13F	Company	0.15%	75,000	$1,442,250	—	30 Sep 2025	13F
Resolute Capital Asset Partners LLC	13F	Company	0.15%	75,000	$1,442,250	—	30 Sep 2025	13F
Bank of New York Mellon Corp	13F	Company	0.14%	70,632	$1,358,254	—	30 Sep 2025	13F
Jefferies Financial Group Inc.	13F	Company	0.13%	64,991	$1,249,777	—	30 Sep 2025	13F
TORONTO DOMINION BANK	13F	Company	0.12%	58,332	$1,121,724	—	30 Sep 2025	13F
MANUFACTURERS LIFE INSURANCE COMPANY, THE	13F	Company	0.1%	51,908	$998,191	—	30 Sep 2025	13F
KENNEDY CAPITAL MANAGEMENT LLC	13F	Company	0.1%	48,266	$928,155	—	30 Sep 2025	13F
TD ASSET MANAGEMENT INC	13F	Company	0.09%	45,876	$882,195	—	30 Sep 2025	13F

Institutional Holders of Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share (ORKA) as of Q4 2025

As of 31 Dec 2025, Oruka Therapeutics, Inc. - Common Stock, $0.001 par value per share (ORKA) was held by 143 institutional shareholders that filed Form 13F with the SEC. Together, they reported ownership of 52,853,940 shares. The largest 10 holders included FMR LLC, VR ADVISER, LLC, Fairmount Funds Management LLC, BlackRock, Inc., VIKING GLOBAL INVESTORS LP, VANGUARD GROUP INC, Deep Track Capital, LP, RTW INVESTMENTS, LP, Commodore Capital LP, and Paradigm Biocapital Advisors LP. This page lists 143 institutional shareholders reporting positions in this security for the Q4 2025 filing period.

Investor	Option	Weight %	Change %	Value $	* Price	Shares	Share Change	Activity	Report Period

Compare Q4 2025 vs Q3 2025 Across Filers

Q3 2025 holders

104

Q4 2025 holders

143

Holder diff

Investor	Q3 2025 Shares	Q4 2025 Shares	Share Diff	Share Chg %	Q3 2025 Value $	Q4 2025 Value $	Value Diff $	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend

* Reported Price is the price of the security as of the portfolio date. This value is significant in that it is the last known price at which the security was still held.
An asterisk sign (*) next to the price indicates that the price is likely invalid.