Oruka Therapeutics, Inc. - Common stock, $0.001 Par Value (ORKA) Institutional Ownership

13F Institutional Holders and Ownership History from Q3 2024 to Q4 2025

Type / Class
Equity / Common stock, $0.001 Par Value
Symbol
ORKA on Nasdaq
Shares outstanding
48,355,928
Price per share
$30.31
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
18,666,392
Total reported value
$565,820,621
% of total 13F portfolios
0%
Share change
+4,235,564
Value change
+$129,093,371
Number of holders
89
Price from insider filings
$30.31
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of Oruka Therapeutics, Inc. - Common stock, $0.001 Par Value (ORKA) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Fairmount Funds Management LLC 20% 0% $161,971,372 +$38,464,806 11,162,741 +31% Fairmount Funds Management LLC 17 Sep 2025
Venrock Healthcare Capital Partners III, L.P. 9.9% -11% $94,411,973 +$14,637,703 4,909,619 +18% Venrock Healthcare Capital Partners III, L.P. 30 Sep 2025
BlackRock, Inc. 6.6% +42% $96,248,890 +$29,642,149 3,175,483 +45% BlackRock, Inc. 31 Dec 2025
VIKING GLOBAL INVESTORS LP 5.5% $38,693,672 2,666,690 VIKING GLOBAL INVESTORS LP 17 Sep 2025
VANGUARD GROUP INC 5.1% $74,366,494 2,453,530 The Vanguard Group 31 Dec 2025
Deep Track Capital, LP 4.5% -12% $65,515,368 +$8,023,966 2,161,510 +14% Deep Track Capital, LP 31 Dec 2025
RTW INVESTMENTS, LP 5.2% $20,429,314 1,945,649 RTW Investments, LP 31 Mar 2025

As of 31 Dec 2025, 89 institutional investors reported holding 18,666,392 shares of Oruka Therapeutics, Inc. - Common stock, $0.001 Par Value (ORKA). This represents 39% of the company’s total 48,355,928 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of Oruka Therapeutics, Inc. - Common stock, $0.001 Par Value (ORKA) together control 37% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
BlackRock, Inc. 7.3% 3,539,415 +61% 0% $107,279,669
VANGUARD GROUP INC 5.1% 2,453,530 +38% 0% $74,366,494
Deep Track Capital, LP 4.5% 2,161,510 -19% 1.5% $65,515,368
Remedium Capital Partners, LLC 3.2% 1,552,414 0% 28% $47,054,000
STATE STREET CORP 2.9% 1,383,847 +112% 0% $41,944,403
GEODE CAPITAL MANAGEMENT, LLC 1.9% 942,507 +37% 0% $28,574,387
FRANKLIN RESOURCES INC 1.9% 938,421 -12% 0.01% $28,443,541
Affinity Asset Advisors, LLC 1.7% 802,342 -16% 1.7% $24,318,986
Avidity Partners Management LP 1.4% 660,424 0% 5.8% $20,017,451
Synergy Asset Management, LLC 0.95% 458,946 1.4% $13,910,653
SR One Capital Management, LP 0.89% 430,330 0% 1.8% $13,043,302
Candriam S.C.A. 0.83% 400,509 +9.1% 0.06% $12,139,945
CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.68% 329,496 +33% 0% $9,987,024
UBS Group AG 0.56% 271,013 +213% 0% $8,214,404
Soleus Capital Management, L.P. 0.39% 190,000 0.24% $5,758,900
BARCLAYS PLC 0.36% 173,329 +82% 0% $5,253,602
Moody Aldrich Partners LLC 0.26% 126,812 0.72% $3,843,672
MORGAN STANLEY 0.25% 122,198 -9.4% 0% $3,703,822
DEUTSCHE BANK AG\ 0.25% 119,329 +439% 0% $3,616,862
Kalehua Capital Management LLC 0.25% 118,524 0% 3.6% $3,592,462
Bank of New York Mellon Corp 0.24% 114,173 +62% 0% $3,460,584
Alyeska Investment Group, L.P. 0.21% 100,000 0.01% $3,031,000
GOLDMAN SACHS GROUP INC 0.19% 92,995 +370% 0% $2,818,678
Nuveen, LLC 0.18% 86,347 +145% 0% $2,617,178
Secure Asset Management, LLC 0.17% 81,664 0.39% $2,475,247

Institutional Holders of Oruka Therapeutics, Inc. - Common stock, $0.001 Par Value (ORKA) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 18,666,392 $565,820,621 +$129,093,371 $30.31 89
2025 Q3 45,557,412 $875,823,009 +$220,884,566 $19.23 104
2025 Q2 34,429,035 $385,950,468 +$30,431,109 $11.21 81
2025 Q1 31,776,517 $326,087,518 -$21,453,560 $10.26 70
2024 Q4 31,038,311 $606,624,310 +$125,781,752 $19.39 66
2024 Q3 24,559,501 $604,174,991 +$603,646,384 $24.51 41