Latest Period
Q4 2025
Security Snapshot
INSMED Inc - Common Stock (INSM) Institutional Ownership
CUSIP: 457669307
13F Institutional Holders and Ownership History from Q1 2014 to Q1 2026
Institutions Reporting
669
Shares (Excl. Options)
212,471,045
Price
$174.04
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- Type / Class
- Equity / Common Stock
- Symbol
- INSM on Nasdaq
- Shares outstanding
- 215,634,700
- Price per share
- $160.18
- All holders as of 31 Dec 2025
- Q4 2025
- Total 13F shares
- 212,471,045
- Total reported value
- $36,986,833,117
- % of total 13F portfolios
- 0.03%
- Share change
- -26,576
- Value change
- +$197,646,332
- Number of holders
- 669
- Price from insider filings
- $160.18
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors
Quick Takeaways
- INSM - INSMED Inc - Common Stock is tracked under CUSIP 457669307.
- 669 institutions reported positions in Q4 2025.
- 5 significant owners is listed from Schedule 13D/13G reporting.
What Changed
- Holder count moved from 669 to 183 between Q4 2025 and Q1 2026.
- Reported value moved from $36,986,833,117 to $884,670,672.
Why This Matters
- You can quickly see who holds this security, then open quarter and manager detail pages for full evidence.
- 13F and Schedule 13D/13G sections are kept together so you can cross-check institutional and beneficial ownership context.
Source Evidence
Source: SEC Form 13F
Open SEC Evidence
Latest holder context comes from 669 institutions filings for Q4 2025.
Investment Quick Answers
What is CUSIP 457669307?
CUSIP 457669307 identifies INSM - INSMED Inc - Common Stock in SEC 13F datasets.
Where can I see the latest institutional holders?
Review the Q4 2025 holders report and the ownership history table below.
Next ownership checks
Use the next link that matches the question you still need to answer about this security.
- Latest 13F filings when you want to inspect fresh institutional portfolio moves.
- Latest Schedule 13D/13G reports when you need large-owner changes outside the 13F cycle.
- All institutional ownership pages to compare this security with other holder-history pages.
Recent Quarterly Holder Reports
Open recent reporting periods for CUSIP 457669307:
Significant Owners of INSMED Inc - Common Stock (INSM) based on Schedule 13D/G filings
| Filer | Ownership | Change % | Holdings Value | Net Change | Nb Shares | Change % | Reporting Name | Report Period |
|---|---|---|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 11% | +36% | $2,827,801,936 | +$964,491,533 | 23,014,584 | +52% | JPMORGAN CHASE & CO. | 29 Aug 2025 |
| Darwin Global Management, Ltd. | 9.7% | +13% | $2,946,076,654 | +$728,614,275 | 20,457,445 | +33% | Darwin Global Management, Ltd. | 30 Sep 2025 |
| BlackRock, Inc. | 6.6% | +30% | $2,457,696,288 | +$764,349,568 | 14,121,445 | +45% | BlackRock, Inc. | 31 Dec 2025 |
| VANGUARD CAPITAL MANAGEMENT LLC | 5.3% | $1,882,915,303 | 11,514,893 | Vanguard Capital Management | 31 Mar 2026 | |||
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.3% | -43% | $998,278,616 | -$619,088,189 | 6,932,009 | -38% | T. Rowe Price Associates, Inc. | 30 Sep 2025 |
As of 31 Dec 2025, 669 institutional investors reported holding 212,471,045 shares of INSMED Inc - Common Stock (INSM). This represents 99% of the company’s total 215,634,700 outstanding shares.
Top 25 Institutional Shareholders
The largest institutional shareholders of INSMED Inc - Common Stock (INSM) together control 72% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.
| Institution | Ownership % | Shares Held | Share Change % | Portfolio % | Holdings Value |
|---|---|---|---|---|---|
| JPMORGAN CHASE & CO | 11% | 23,199,512 | +0.66% | 0.27% | $4,037,643,311 |
| VANGUARD GROUP INC | 9.8% | 21,076,344 | +5.7% | 0.05% | $3,668,126,910 |
| Darwin Global Management, Ltd. | 9.7% | 20,933,277 | +2.3% | 74% | $3,644,274,193 |
| BlackRock, Inc. | 7% | 15,065,052 | +22% | 0.04% | $2,621,921,693 |
| FMR LLC | 4.6% | 9,927,936 | +8.1% | 0.09% | $1,727,857,942 |
| BAKER BROS. ADVISORS LP | 3.1% | 6,592,746 | -1.7% | 6.7% | $1,147,401,514 |
| STATE STREET CORP | 2.4% | 5,201,744 | +31% | 0.03% | $905,311,526 |
| Capital International Investors | 2.4% | 5,151,671 | -32% | 0.14% | $896,597,082 |
| Artisan Partners Limited Partnership | 2.2% | 4,843,749 | -1.9% | 1.3% | $843,006,016 |
| RTW INVESTMENTS, LP | 2.2% | 4,842,879 | +57% | 8.4% | $842,854,661 |
| D. E. Shaw & Co., Inc. | 2% | 4,350,995 | -23% | 0.58% | $757,247,170 |
| GEODE CAPITAL MANAGEMENT, LLC | 2% | 4,299,052 | +14% | 0.05% | $751,935,864 |
| Orbis Allan Gray Ltd | 1.9% | 4,179,957 | +29% | 3% | $727,479,716 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.9% | 4,039,466 | -42% | 0.08% | $703,030,000 |
| NORGES BANK | 1.3% | 2,910,971 | 0.05% | $506,625,393 | |
| FRANKLIN RESOURCES INC | 1.3% | 2,755,536 | +29% | 0.12% | $479,573,482 |
| Invesco Ltd. | 1.3% | 2,726,857 | +36% | 0.07% | $474,582,256 |
| AMERIPRISE FINANCIAL INC | 0.91% | 1,968,857 | -28% | 0.08% | $342,660,797 |
| UBS Group AG | 0.87% | 1,867,635 | +13% | 0.06% | $325,043,194 |
| BANK OF AMERICA CORP /DE/ | 0.8% | 1,725,681 | +7.7% | 0.02% | $300,337,528 |
| MORGAN STANLEY | 0.76% | 1,631,905 | +69% | 0.02% | $284,017,140 |
| Duquesne Family Office LLC | 0.69% | 1,481,752 | -39% | 6.1% | $257,884,000 |
| Bank of New York Mellon Corp | 0.64% | 1,390,042 | +22% | 0.04% | $241,922,940 |
| MILLENNIUM MANAGEMENT LLC | 0.61% | 1,311,654 | -44% | 0.16% | $228,280,262 |
| Castle Hook Partners LP | 0.58% | 1,253,568 | +15% | 3.1% | $218,170,975 |
Institutional Holders of INSMED Inc - Common Stock (INSM) across Reporting Periods
| Period | Reported Shares, Excl. Options | Value, Excl. Options | Value Change | Price (Median) | Investors |
|---|---|---|---|---|---|
| 2026 Q1 | 5,421,298 | $884,670,672 | +$5,764,516 | $163.52 | 183 |
| 2025 Q4 | 212,471,045 | $36,986,833,117 | +$197,646,332 | $174.04 | 669 |
| 2025 Q3 | 210,868,315 | $30,324,118,550 | +$447,494,143 | $144.01 | 563 |
| 2025 Q2 | 210,375,071 | $21,148,644,502 | +$1,358,877,009 | $100.64 | 513 |
| 2025 Q1 | 197,789,205 | $15,117,195,698 | +$439,219,800 | $76.29 | 436 |
| 2024 Q4 | 192,544,545 | $13,293,875,240 | +$244,780,319 | $69.04 | 434 |
| 2024 Q3 | 188,054,494 | $13,732,893,406 | +$900,536,797 | $73.00 | 411 |
| 2024 Q2 | 175,240,601 | $11,740,766,805 | +$1,771,359,793 | $67.00 | 375 |
| 2024 Q1 | 149,761,616 | $4,062,731,615 | -$1,104,814 | $27.13 | 284 |
| 2023 Q4 | 149,731,871 | $4,640,473,667 | +$24,712,854 | $30.99 | 269 |
| 2023 Q3 | 147,357,091 | $3,720,846,962 | +$68,976,618 | $25.25 | 249 |
| 2023 Q2 | 146,401,839 | $3,087,320,690 | +$30,211,671 | $21.10 | 221 |
| 2023 Q1 | 145,487,988 | $2,479,157,946 | +$29,238,110 | $17.05 | 229 |
| 2022 Q4 | 143,724,717 | $2,870,747,315 | +$305,150,296 | $19.98 | 224 |
| 2022 Q3 | 127,521,278 | $2,746,157,362 | -$212,666,313 | $21.54 | 229 |
| 2022 Q2 | 129,190,615 | $2,547,619,834 | +$40,332,207 | $19.72 | 200 |
| 2022 Q1 | 126,479,239 | $2,971,923,265 | +$75,140,734 | $23.50 | 211 |
| 2021 Q4 | 123,318,469 | $3,358,792,092 | -$21,477,249 | $27.24 | 201 |
| 2021 Q3 | 123,374,100 | $3,397,087,163 | +$40,469,427 | $27.54 | 184 |
| 2021 Q2 | 121,478,330 | $3,456,376,124 | +$431,176,988 | $28.46 | 194 |
| 2021 Q1 | 106,602,088 | $3,631,335,192 | -$6,653,428 | $34.06 | 194 |
| 2020 Q4 | 107,580,874 | $3,581,395,788 | -$44,371,673 | $33.29 | 202 |
| 2020 Q3 | 108,714,504 | $3,495,053,137 | -$56,966,505 | $32.14 | 195 |
| 2020 Q2 | 110,715,810 | $3,045,474,894 | +$374,929,259 | $27.54 | 183 |
| 2020 Q1 | 97,643,990 | $1,563,236,817 | -$41,156,048 | $16.03 | 159 |
| 2019 Q4 | 98,329,079 | $2,348,053,229 | -$38,855,319 | $23.88 | 169 |
| 2019 Q3 | 99,035,921 | $1,747,100,746 | -$518,153,737 | $17.64 | 153 |
| 2019 Q2 | 126,395,360 | $3,235,565,096 | +$1,146,114,720 | $25.60 | 165 |
| 2019 Q1 | 82,194,605 | $2,389,348,616 | -$1,132,072 | $29.07 | 151 |
| 2018 Q4 | 82,419,564 | $1,081,320,258 | -$9,481,669 | $13.12 | 120 |
| 2018 Q3 | 80,880,640 | $1,635,485,434 | -$43,612,626 | $20.22 | 120 |
| 2018 Q2 | 82,447,822 | $1,949,876,562 | +$16,668,558 | $23.65 | 125 |
| 2018 Q1 | 81,818,840 | $1,842,516,409 | +$127,505,884 | $22.52 | 125 |
| 2017 Q4 | 75,871,275 | $2,365,660,554 | +$39,137,828 | $31.18 | 125 |
| 2017 Q3 | 73,705,883 | $2,300,049,892 | +$548,691,894 | $31.21 | 142 |
| 2017 Q2 | 56,526,187 | $969,760,710 | +$39,905,047 | $17.16 | 110 |
| 2017 Q1 | 56,998,661 | $998,026,125 | +$70,030,475 | $17.51 | 97 |
| 2016 Q4 | 57,799,199 | $764,693,750 | +$2,353,629 | $13.23 | 96 |
| 2016 Q3 | 57,474,912 | $834,201,194 | +$19,054,121 | $14.52 | 93 |
| 2016 Q2 | 56,451,131 | $556,714,141 | -$8,091,952 | $9.86 | 103 |
| 2016 Q1 | 57,022,278 | $722,305,325 | -$13,027,221 | $12.67 | 97 |
| 2015 Q4 | 56,887,745 | $1,032,792,029 | -$19,917 | $18.15 | 111 |
| 2015 Q3 | 56,767,734 | $1,053,879,972 | +$35,530,012 | $18.57 | 117 |
| 2015 Q2 | 54,410,404 | $1,328,450,938 | +$21,929,946 | $24.42 | 115 |
| 2015 Q1 | 53,709,876 | $1,117,417,187 | +$261,082,690 | $20.80 | 117 |
| 2014 Q4 | 41,928,477 | $648,686,215 | +$11,193,962 | $15.47 | 94 |
| 2014 Q3 | 41,271,273 | $538,679,902 | +$115,361,476 | $13.05 | 99 |
| 2014 Q2 | 31,011,972 | $619,318,286 | +$3,350,731 | $19.98 | 102 |
| 2014 Q1 | 30,157,438 | $573,214,840 | +$41,465,686 | $19.04 | 108 |