| Name | Ownership | Shares Owned | sole voting power | shared voting power | Signature | Title | CIK |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 14% | 15,252,867 | 0 | 15,252,867 | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001055951 |
| ORBIMED CAPITAL GP VI LLC | 14% | 14,809,075 | 0 | 14,809,075 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC (ORBIMED ADVISORS LLC, its managing member) | 0001682115 |
| OrbiMed Genesis GP LLC | 0.4% | 443,792 | 0 | 443,792 | /s/ Carl L. Gordon | Carl L. Gordon/Member of OrbiMed Advisors LLC (ORBIMED ADVISORS LLC, its managing member) | 0001808744 |
| ORBIMED CAPITAL LLC | 0.3% | 265,625 | 265,625 | 0 | /s/ Carl L. Gordon | Carl L. Gordon/Member | 0001157524 |