Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share (AMLX)

CUSIP: 03237H101

Q3 2025 13F Holders as of 30 Sep 2025

Type / Class
Equity / Common Stock, $0.0001 par value per share
Shares outstanding
110,465,093
Total 13F shares
109,720,694
Share change
+28,023,346
Total reported value
$1,491,122,082
Put/Call ratio
37%
Price per share
$13.59
Number of holders
168
Value change
+$396,029,872
Number of buys
99
Number of sells
67

Security key

03237H101

Report period

Q3 2025

Institutions

168

Top holders

10

Ownership snapshot

Top shareholders of AMLX - Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Lead holder
Point72 Asset Management,...
13D/G signal
Point72 Asset Management,...
Evidence rows
50
Latest as of
30 Sep 2025
13D/G 13F Lead comparable stake: 2.6% 13D/G row: Point72 Asset Management, L.P. Showing first 8 of 50 holder rows. Open remaining rows
Holder Evidence Ownership % Position 12M Net Δ As of
Point72 Asset Management, L.P.
13D/G 13F
Company
2.6%
$38,074,233
2,801,636 shares
-$26,039,432 30 Sep 2025
Panacea Innovation Ltd
13D/G
Panacea Venture Healthcare Fund II, L.P.
2.6%
$11,792,000
2,200,000 shares
$0 31 Dec 2024
ADAGE CAPITAL PARTNERS GP, L.L.C.
13F
Company
13F
8%
$56,408,000
8,800,000 shares
30 Jun 2025
PERCEPTIVE ADVISORS LLC
13F
Company
13F
7.2%
$50,654,160
7,902,365 shares
30 Jun 2025
TCG Crossover Management, LLC
13F
Company
13F
5.4%
$38,099,835
5,943,812 shares
30 Jun 2025
BlackRock, Inc.
13F
Company
13F
5%
$35,320,311
5,510,189 shares
30 Jun 2025
VANGUARD GROUP INC
13F
Company
13F
4.1%
$28,832,360
4,498,028 shares
30 Jun 2025
Saturn V Capital Management LP
13F
Company
13F
3%
$20,900,254
3,260,570 shares
30 Jun 2025
Show 42 additional holder rows in the full holder list
Holder Evidence Ownership % Position 12M Net Δ As of
FMR LLC
13F
Company
13F
2.8%
$19,537,802
3,048,019 shares
30 Jun 2025
Nantahala Capital Management, LLC
13F
Company
13F
2.7%
$18,809,536
2,934,405 shares
30 Jun 2025
683 Capital Management, LLC
13F
Company
13F
2%
$13,845,600
2,160,000 shares
30 Jun 2025
Almitas Capital LLC
13F
Company
13F
1.9%
$13,605,847
2,122,597 shares
30 Jun 2025
GREAT POINT PARTNERS LLC
13F
Company
13F
1.8%
$12,820,000
2,000,000 shares
30 Jun 2025
GEODE CAPITAL MANAGEMENT, LLC
13F
Company
13F
1.5%
$10,850,718
1,692,413 shares
30 Jun 2025
MILLENNIUM MANAGEMENT LLC
13F
Company
13F
1.4%
$9,692,292
1,512,058 shares
30 Jun 2025
GOLDMAN SACHS GROUP INC
13F
Company
13F
1.2%
$8,320,065
1,297,982 shares
30 Jun 2025
DRIEHAUS CAPITAL MANAGEMENT LLC
13F
Company
13F
1.1%
$8,108,631
1,264,997 shares
30 Jun 2025
UBS Group AG
13F
Company
13F
1.1%
$8,033,935
1,253,344 shares
30 Jun 2025
CITADEL ADVISORS LLC
13F
Company
13F
1.1%
$7,967,162
1,242,927 shares
30 Jun 2025
Boxer Capital Management, LLC
13F
Company
13F
1.1%
$7,852,250
1,225,000 shares
30 Jun 2025
ADAR1 Capital Management, LLC
13F
Company
13F
1.1%
$7,724,697
1,205,101 shares
30 Jun 2025
Woodline Partners LP
13F
Company
13F
1.1%
$7,693,859
1,200,290 shares
30 Jun 2025
Connor, Clark & Lunn Investment Management Ltd.
13F
Company
13F
1%
$7,400,249
1,154,485 shares
30 Jun 2025
STATE STREET CORP
13F
Company
13F
0.91%
$6,467,107
1,008,909 shares
30 Jun 2025
NORTHERN TRUST CORP
13F
Company
13F
0.74%
$5,257,251
820,164 shares
30 Jun 2025
Aberdeen Group plc
13F
Company
13F
0.67%
$4,734,791
738,657 shares
30 Jun 2025
PFM Health Sciences, LP
13F
Company
13F
0.66%
$4,693,761
732,256 shares
30 Jun 2025
Parkman Healthcare Partners LLC
13F
Company
13F
0.59%
$4,166,500
650,000 shares
30 Jun 2025
Schonfeld Strategic Advisors LLC
13F
Company
13F
0.59%
$4,143,699
646,443 shares
30 Jun 2025
DEUTSCHE BANK AG\
13F
Company
13F
0.56%
$3,954,451
616,919 shares
30 Jun 2025
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
13F
Company
13F
0.53%
$3,771,715
588,411 shares
30 Jun 2025
Invesco Ltd.
13F
Company
13F
0.53%
$3,761,920
586,883 shares
30 Jun 2025
ACADIAN ASSET MANAGEMENT LLC
13F
Company
13F
0.52%
$3,645,000
569,083 shares
30 Jun 2025
TWO SIGMA INVESTMENTS, LP
13F
Company
13F
0.51%
$3,582,203
558,846 shares
30 Jun 2025
Rock Springs Capital Management LP
13F
Company
13F
0.45%
$3,203,487
499,764 shares
30 Jun 2025
MORGAN STANLEY
13F
Company
13F
0.44%
$3,120,984
486,893 shares
30 Jun 2025
TWO SIGMA ADVISERS, LP
13F
Company
13F
0.43%
$3,012,700
470,000 shares
30 Jun 2025
BANK OF AMERICA CORP /DE/
13F
Company
13F
0.41%
$2,896,090
451,808 shares
30 Jun 2025
Qube Research & Technologies Ltd
13F
Company
13F
0.4%
$2,807,747
438,026 shares
30 Jun 2025
RENAISSANCE TECHNOLOGIES LLC
13F
Company
13F
0.36%
$2,539,642
396,200 shares
30 Jun 2025
DIMENSIONAL FUND ADVISORS LP
13F
Company
13F
0.34%
$2,395,083
373,739 shares
30 Jun 2025
ORBIMED ADVISORS LLC
13F
Company
13F
0.28%
$2,007,612
313,200 shares
30 Jun 2025
WELLINGTON MANAGEMENT GROUP LLP
13F
Company
13F
0.26%
$1,850,040
288,618 shares
30 Jun 2025
Alpha Wave Global, LP
13F
Company
13F
0.25%
$1,768,147
275,842 shares
30 Jun 2025
J. Goldman & Co LP
13F
Company
13F
0.23%
$1,657,626
258,600 shares
30 Jun 2025
Y-Intercept (Hong Kong) Ltd
13F
Company
13F
0.22%
$1,540,829
240,379 shares
30 Jun 2025
Tetragon Partners GP Ltd
13F
Company
13F
0.2%
$1,402,188
218,750 shares
30 Jun 2025
Aldebaran Capital, LLC
13F
Company
13F
0.2%
$1,396,271
217,827 shares
30 Jun 2025
FEDERATED HERMES, INC.
13F
Company
13F
0.18%
$1,307,191
203,930 shares
30 Jun 2025
JANE STREET GROUP, LLC
13F
Company
13F
0.17%
$1,198,580
186,986 shares
30 Jun 2025
How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q3 2025

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions
168
Shares
109,720,694
Rows loaded
169
Investor Option Weight % Change % Reported value * Price Shares Share Change Activity Report Period

* Reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. An asterisk next to the price means the price is likely invalid.

Compare Q3 2025 vs Q2 2025 Across Filers

Q2 2025 holders
131
Q3 2025 holders
168
Holder diff
37
Investor Q2 2025 Shares Q3 2025 Shares Share Diff Share Chg % Q2 2025 value Q3 2025 value Value change Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend
Quarterly Value Trend
Quarterly Shares Trend
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