Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share (AMLX)

Q: What does CUSIP 03237H101 represent in this 13F holders report?

CUSIP 03237H101 is the security identifier for AMLX - Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share used to aggregate holder disclosures.

Q: How many institutions held AMLX - Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share in Q3 2025?

168 institutional investors reported AMLX - Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share for Q3 2025. Use the holders table for investor-level position and value details.

CUSIP: 03237H101

Q3 2025 13F Holders as of 30 Sep 2025

Security type / class: Equity / Common Stock, $0.0001 par value per share
Total 13F shares: 109,720,694
Total 13F value: $1,491,122,082
Share change: +28,023,346
Put/Call ratio: 37%
SEC-reported price per share: $13.59
Number of holders: 168
Value change: +$396,029,872
Number of buys: 99
Number of sells: 67
Shares outstanding: 110,465,093

Security key

03237H101

Report period

Q3 2025

Institutions

168

Top holders

AMLX full security history Ownership snapshot Full 13F holder table Newer quarter: Q4 2025 Previous quarter: Q2 2025 Amylyx Pharmaceuticals, Inc. SEC filings Amylyx Pharmaceuticals, Inc. company facts

Broader feeds

Latest 13F filings Latest 13D/G filings Investors directory

Reporting periods

Holder history for CUSIP 03237H101

Newer quarter: Q4 2025 Previous quarter: Q2 2025

Recent filing periods:

Q2 2026 Q1 2026 Q4 2025 Q3 2025 Q2 2025 Q1 2025 Q4 2024 Q3 2024

Ownership snapshot

Top reported holders of AMLX - Amylyx Pharmaceuticals, Inc. - Common Stock, $0.0001 par value per share (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Start with comparable ownership when available, then verify the linked 13F, 13D/G, or 3/4/5 evidence.

Comparable stake leader

Point72 Asset Management,...

Disclosed value leader

ADAGE CAPITAL PARTNERS GP...

Comparable rows

15/15

Latest evidence

30 Sep 2025

13D/G 13F Lead comparable stake: 2.6% 13D/G row: Point72 Asset Management, L.P. Showing 1-6 of 15 holder rows.

Quick read

Point72 Asset Management, L.P. leads the comparable SEC ownership view at 2.6%.

15 of 15 rows have a safely comparable ownership percentage. Use this as a filing-backed starting point, then open the detailed table for source links, reporting role, position value, share count, and filing date.

Open SEC evidence Opens Point72 Asset Management, L.P.'s linked filing trail.

Comparable ownership Top 5

Point72 Asset Management, L.P. 2.6%

Panacea Innovation Ltd 2.6%

ADAGE CAPITAL PARTNERS GP, L.L.C. 8%

PERCEPTIVE ADVISORS LLC 7.2%

TCG Crossover Management, LLC 5.4%

Ownership % is shown only when SEC disclosures are safely comparable across share classes.

Detailed SEC evidence table Showing 1-6 of 15 holder rows

Holder	Evidence	Ownership %	Position	12M Net Δ	As of
Point72 Asset Management, L.P.	13D/G 13F Company 13D/G 13F	2.6%	$38,074,233 2,801,636 shares	-$26,039,432	30 Sep 2025
Panacea Innovation Ltd	13D/G Panacea Venture Healthcare Fund II, L.P. 13D/G	2.6%	$11,792,000 2,200,000 shares	$0	31 Dec 2024
ADAGE CAPITAL PARTNERS GP, L.L.C.	13F Company 13F	8%	$56,408,000 8,800,000 shares	—	30 Jun 2025
PERCEPTIVE ADVISORS LLC	13F Company 13F	7.2%	$50,654,160 7,902,365 shares	—	30 Jun 2025
TCG Crossover Management, LLC	13F Company 13F	5.4%	$38,099,835 5,943,812 shares	—	30 Jun 2025
BlackRock, Inc.	13F Company 13F	5%	$35,320,311 5,510,189 shares	—	30 Jun 2025

How to read this table

Rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

13F holder rows

Institutional holders as of Q3 2025

Investor-level positions for this CUSIP, loaded as an interactive table.

Institutions

168

109,720,694

Rows available

168

Investor	Option	Weight %	Change %	SEC-reported value	* Price	Shares	Share Change	Activity	Report Period

^* SEC-reported price is the security price as of the portfolio date and can indicate the last known price at which the security was still held. The marker flags a reported price that did not pass the local price check.

Compare Q3 2025 vs Q2 2025 Across Filers

Q2 2025 holders

131

Q3 2025 holders

168

Holder diff

Investor	Q2 2025 Shares	Q3 2025 Shares	Share Diff	Share Chg %	Q2 2025 value	Q3 2025 value	Value change	Value Chg %

Trend: ostatnie 8 kwartałów (+ wybrane okresy porównania).

Quarterly Holders Trend

Quarterly Value Trend

Quarterly Shares Trend