TALPHERA, INC. - Common Stock (TLPH) Institutional Ownership

13F Institutional Holders and Ownership History from Q4 2022 to Q4 2025

Type / Class
Equity / Common Stock
Symbol
TLPH on Nasdaq
Shares outstanding
46,283,356
Price per share
$0.99
All holders as of 31 Dec 2025
Q4 2025
Total 13F shares
20,869,642
Total reported value
$23,791,546
% of total 13F portfolios
0%
Share change
+1,756,450
Value change
+$2,013,982
Number of holders
38
Price from insider filings
$0.99
Reported Shares, Excluding Options vs Price
Reported Value, Excluding Options
Total Investors

Significant Owners of TALPHERA, INC. - Common Stock (TLPH) based on Schedule 13D/G filings

Filer Ownership Change % Holdings Value Net Change Nb Shares Change % Reporting Name Report Period
Rosalind Advisors, Inc. 9.9% 0% $13,545,483 -$830,679 13,150,954 -5.8% Rosalind Advisors, Inc. 31 Dec 2025
CorMedix Inc. 20% $3,909,091 9,090,909 CorMedix Inc. 07 Sep 2025
HIRSCHMAN ORIN 9.8% +1% $5,127,652 +$227,653 4,661,502 +4.6% Orin Hirschman 31 Dec 2025
Rock Springs Capital Management LP 7.9% $1,543,350 3,589,186 Rock Springs Capital Management LP 10 Sep 2025
LYTTON LAURENCE W 5.9% -26% $2,812,640 -$932,815 2,730,718 -25% LYTTON LAURENCE W 31 Dec 2025
Nantahala Capital Management, LLC 12% $976,334 1,992,519 Nantahala Capital Management, LLC 31 Mar 2025

As of 31 Dec 2025, 38 institutional investors reported holding 20,869,642 shares of TALPHERA, INC. - Common Stock (TLPH). This represents 45% of the company’s total 46,283,356 outstanding shares.

Top 25 Institutional Shareholders

The largest institutional shareholders of TALPHERA, INC. - Common Stock (TLPH) together control 45% of the company’s outstanding shares — a level of ownership often associated with strong institutional conviction and long‑term capital commitment.

Institution Ownership % Shares Held Share Change % Portfolio % Holdings Value
AIGH Capital Management LLC 10% 4,661,502 +4.6% 1.6% $5,314,112
Rock Springs Capital Management LP 7.8% 3,589,186 0% 0.21% $4,091,672
Rosalind Advisors, Inc. 7.7% 3,579,273 -18% 1.6% $4,080,371
Nantahala Capital Management, LLC 7.5% 3,492,519 0% 0.24% $3,981,472
Empery Asset Management, LP 2.9% 1,333,497 0% 1.3% $1,520,187
Bleichroeder LP 1.9% 881,166 0% 0.18% $1,004,529
VANGUARD GROUP INC 1.4% 663,677 +132% 0% $756,593
Dauntless Investment Group, LLC 1.3% 579,320 +479% 2.6% $660,425
CANTOR FITZGERALD, L. P. 1.2% 577,490 0.02% $658,339
GEODE CAPITAL MANAGEMENT, LLC 0.74% 342,987 +107% 0% $391,071
RENAISSANCE TECHNOLOGIES LLC 0.56% 257,380 +413% 0% $293,413
DIADEMA PARTNERS LP 0.3% 136,923 0.09% $156,092
BlackRock, Inc. 0.2% 91,548 0% 0% $104,365
SIMPLEX TRADING, LLC 0.19% 85,799 +6893% 0% $97,810
JANE STREET GROUP, LLC 0.18% 84,938 0% $96,830
Values First Advisors, Inc. 0.18% 81,208 -17% 0.05% $92,577
CITADEL ADVISORS LLC 0.17% 76,445 0% $87,147
Mariner, LLC 0.13% 58,000 +132% 0% $66,120
GROUP ONE TRADING LLC 0.12% 57,173 +88% 0% $65,177
SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.12% 56,432 0% $64,332
NORTHERN TRUST CORP 0.11% 52,580 +383% 0% $59,941
Persistent Asset Partners Ltd 0.08% 36,630 0.02% $41,758
TWO SIGMA INVESTMENTS, LP 0.05% 24,588 0% $28,030
STATE STREET CORP 0.05% 22,182 0% 0% $25,287
GSA CAPITAL PARTNERS LLP 0.05% 20,973 0% $24,000

Institutional Holders of TALPHERA, INC. - Common Stock (TLPH) across Reporting Periods

Period Reported Shares, Excl. Options Value, Excl. Options Value Change Price (Median) Investors
2025 Q4 20,869,642 $23,791,546 +$2,013,982 $1.14 38
2025 Q3 17,779,695 $15,882,401 +$11,174,625 $0.89 34
2025 Q2 5,282,528 $2,434,944 -$116,912 $0.46 31
2025 Q1 5,523,842 $2,735,875 +$712,867 $0.50 32
2024 Q4 4,078,353 $2,137,345 -$64,684 $0.52 34
2024 Q3 4,175,439 $3,577,199 -$153,646 $0.86 28
2024 Q2 4,348,102 $3,869,606 -$74,576 $0.89 29
2024 Q1 4,424,333 $4,557,026 +$722,371 $1.03 31
2023 Q4 4,001,941 $2,941,200 -$1,080 $0.74 31
2023 Q3 3,249,391 $1,884,806 +$1,252,404 $0.58 29
2023 Q2 1,055,164 $1,170,342 +$18,838 $1.11 25
2023 Q1 1,096,573 $720,947 -$934,994 $0.66 30
2022 Q4 1,452,729 $3,282,858 +$3,282,858 $2.26 32