Insider Transactions Reported by 17 Insiders of TALPHERA, INC.

Symbol: TLPH on Nasdaq
Location: San Mateo, CA

Key facts

TLPH - TALPHERA, INC. has 17 insiders with reported activity on this page.
Net insider value flow over the last year: +$304,001.
Recent transaction rows are available for direct filing-level review.

Change

Buy value: $304,001; sell value: $0.
Net share flow: +433,674.

Research use

This page gives a plain-language issuer insider context before you inspect transaction-level evidence.
Use the filing links below to verify timestamps, codes, and ownership impacts directly from SEC forms.

Evidence

Filed on Form 4

Issuer insider activity is sourced from SEC Forms 3, 4, and 5.

See Original Filing

Insider trading overview

Last 12 months

Net insider flow leans to buying over the last 12 months. Net value: +$304,001.

Buys

$304,001

Shares: 433,674

Insiders: 4

Sells

Shares: 0

Insiders: 0

Net

+$304,001

Shares: +433,674

Insiders: 4

Window (months)	Buy shares	Buy $	Sell $	Net $
0-3	213,310	$125,000	$0	+$125,000
3-6	220,364	$179,002	$0	+$179,002
6-9	0	$0	$0	$0
9-12	0	$0	$0	$0

TALPHERA, INC. executives and other stock owners filed with the SEC include:

Name	Relationship	Holdings Value	Past Year Net Change	Change %	Valuation	Report Date
Nantahala Capital Management, LLC	Other*, 10%+ Owner	$6,733,702			Mixed	13 Mar 2026
CorMedix Inc.	10%+ Owner	$3,909,090			Mixed	07 Sep 2025
Vincent J. Angotti	CHIEF EXECUTIVE OFFICER, Director	$901,474	+$210,587	+30%	Mixed	02 Apr 2026
Mark G. Edwards	Director	$189,877			Mixed	17 Jun 2021
Raffi Asadorian	Chief Financial Officer	$172,029	+$36,554	+27%	Mixed	02 Apr 2026
Shakil Aslam	Chief Medical Officer	$82,004	+$28,431	+53%	Mixed	20 May 2026
Badri N. Dasu	Chief Engineering Officer	$81,441	+$28,431	+54%	Mixed	02 Apr 2026
Pamela P. Palmer	Chief Medical Officer	$65,064			Mixed	03 Mar 2024
Adrian Adams	Director	$15,703			Mixed	23 Oct 2025
Marina Bozilenko	Director	$8,068			Mixed	23 Oct 2025
Mark A. Wan	Director	$7,900			Mixed	23 Oct 2025
Stephen J. Hoffman	Director	$7,900			Mixed	23 Oct 2025
Jill Marie Broadfoot	Director	$7,622			Mixed	23 Oct 2025
Abhinav Jain	Director	$6,520			Mixed	23 Oct 2025
Joseph Todisco	Director	$5,821			Mixed	15 Oct 2025
Howard B. Rosen	Director	$3,847			Mixed	10 Oct 2023
Richard Afable	Director	$1,794			Mixed	10 Oct 2023

Top shareholders of TALPHERA, INC. (13F + 13D/G + 3/4/5)

Grouped by holder across the latest SEC ownership disclosures. Ownership % is shown only when it is directly reported or safely comparable across share classes.

Methodology: rows are grouped by holder and ranked first by SEC-reported ownership % when it is safely comparable, then by disclosed holdings value. — indicates unavailable or non-comparable values; "mixed-class rows" means the latest filing spans non-comparable classes.

Holder	Source	Role / Reporting	Ownership %	Shares	Holdings Value	12M Net Δ	As of	Details
CorMedix Inc.	13D/G 3/4/5	10%+ Owner	20%	9,090,909	$3,909,091	$0	07 Sep 2025	13D/G 3/4/5
Nantahala Capital Management, LLC	3/4/5 13D/G 13F	Other*, 10%+ Owner · Company	12% from 13D/G	18,822,267	$6,733,702	—	13 Mar 2026	3/4/5 13D/G 13F
Rosalind Advisors, Inc.	13D/G 13F	Company	9.9%	13,150,954	$13,545,483	-$830,679	31 Dec 2025	13D/G 13F
Orin Hirschman	13D/G	—	9.8%	4,661,502	$5,127,652	+$227,653	31 Dec 2025	13D/G
Rock Springs Capital Management LP	13F 13D/G	Company	7.9% from 13D/G	3,589,186	$2,680,763	—	31 Mar 2026	13F 13D/G
Laurence W. Lytton	13D/G	LYTTON LAURENCE W	2.5%	1,246,444	$1,009,620	-$1,202,262	31 Mar 2026	13D/G
AIGH Capital Management LLC	13F	Company	9.3%	4,661,502	$3,481,676	—	31 Mar 2026	13F
Bleichroeder LP	13F	Company	2.6%	1,307,787	$976,786	—	31 Mar 2026	13F
CANTOR FITZGERALD, L. P.	13F	Individual	1.8%	887,481	$662,860	—	31 Mar 2026	13F
Empery Asset Management, LP	13F	Company	1.2%	590,481	$441,030	—	31 Mar 2026	13F
Caption Management, LLC	13F	Company	1.1%	561,820	$419,623	—	31 Mar 2026	13F
Almitas Capital LLC	13F	Company	0.94%	467,152	$348,916	—	31 Mar 2026	13F
VANGUARD CAPITAL MANAGEMENT LLC	13F	Company	0.89%	441,611	$329,883	—	31 Mar 2026	13F
Dauntless Investment Group, LLC	13F	Company	0.87%	435,234	$325,076	—	31 Mar 2026	13F
GEODE CAPITAL MANAGEMENT, LLC	13F	Company	0.84%	419,980	$313,728	—	31 Mar 2026	13F
Shay Capital LLC	13F	Company	0.5%	250,083	$186,787	—	31 Mar 2026	13F
RENAISSANCE TECHNOLOGIES LLC	13F	Company	0.48%	237,755	$177,579	—	31 Mar 2026	13F
VANGUARD FIDUCIARY TRUST CO	13F	Company	0.39%	192,405	$143,727	—	31 Mar 2026	13F
DIADEMA PARTNERS LP	13F	Company	0.31%	153,563	$114,696	—	31 Mar 2026	13F
CITADEL ADVISORS LLC	13F	Company	0.21%	106,151	$79,284	—	31 Mar 2026	13F
Mariner, LLC	13F	Company	0.2%	100,000	$74,690	—	31 Mar 2026	13F
GSA CAPITAL PARTNERS LLP	13F	Company	0.19%	93,788	$70,000	—	31 Mar 2026	13F
BlackRock, Inc.	13F	Company	0.18%	91,548	$68,377	—	31 Mar 2026	13F
NORTHERN TRUST CORP	13F	Company	0.18%	88,296	$65,948	—	31 Mar 2026	13F
Values First Advisors, Inc.	13F	Company	0.16%	81,517	$60,885	—	31 Mar 2026	13F
SUSQUEHANNA INTERNATIONAL GROUP, LLP	13F	Company	0.1%	50,616	$37,805	—	31 Mar 2026	13F
Persistent Asset Partners Ltd	13F	Company	0.08%	38,968	$29,105	—	31 Mar 2026	13F
Vanguard Global Advisers, LLC	13F	Company	0.06%	29,661	$22,157	—	31 Mar 2026	13F
XTX Topco Ltd	13F	Company	0.05%	25,747	$19,230	—	31 Mar 2026	13F
STATE STREET CORP	13F	Company	0.04%	22,182	$16,568	—	31 Mar 2026	13F
AlphaCore Capital LLC	13F	Company	0.04%	20,670	$15,438	—	31 Mar 2026	13F
HRT FINANCIAL LP	13F	Company	0.04%	19,090	$14,000	—	31 Mar 2026	13F
TWO SIGMA SECURITIES, LLC	13F	Company	0.04%	18,663	$13,939	—	31 Mar 2026	13F
UBS Group AG	13F	Company	0.03%	13,824	$10,326	—	31 Mar 2026	13F
Onyx Bridge Wealth Group LLC	13F	Company	0.02%	11,500	$8,589	—	31 Mar 2026	13F
GROUP ONE TRADING LLC	13F	Company	0.01%	6,676	$4,986	—	31 Mar 2026	13F
MAI Capital Management	13F	Company	0.01%	3,314	$2,476	—	31 Mar 2026	13F
Tower Research Capital LLC (TRC)	13F	Company	0%	1,145	$855	—	31 Mar 2026	13F
WELLS FARGO & COMPANY/MN	13F	Company	0%	983	$734	—	31 Mar 2026	13F
OSAIC HOLDINGS, INC.	13F	Company	0%	285	$213	—	31 Mar 2026	13F
Silicon Valley Capital Partners	13F	Company	0%	137	$102	—	31 Mar 2026	13F
BNP PARIBAS FINANCIAL MARKETS	13F	Company	0%	136	$102	—	31 Mar 2026	13F
SBI Securities Co., Ltd.	13F	Company	0%	113	$84	—	31 Mar 2026	13F
Arax Advisory Partners	13F	Company	0%	81	$61	—	31 Mar 2026	13F
FMR LLC	13F	Company	0%	50	$37	—	31 Mar 2026	13F
Larson Financial Group LLC	13F	Company	0%	30	$22	—	31 Mar 2026	13F
Dogwood Wealth Management LLC	13F	Company	0%	10	$7	—	31 Mar 2026	13F
MORGAN STANLEY	13F	Company	0%	10	$7	—	31 Mar 2026	13F
Vincent J. Angotti	3/4/5	CHIEF EXECUTIVE OFFICER, Director	— mixed-class rows	1,384,767 mixed-class rows	$901,474	+$210,587	02 Apr 2026	3/4/5
Mark G. Edwards	3/4/5	Director	— mixed-class rows	281,250 mixed-class rows	$189,877	—	17 Jun 2021	3/4/5

Recent Insider Transactions by Companies or Individuals for TALPHERA, INC.

Showing up to 300 most recent insider transactions from the last 12 months.

Insider	Symbol	Class	Transaction	%	Value $	* Price $	Shares	Shares Owned	Date	Ownership
Shakil Aslam	TLPH	Common Stock	Tax liability	-5.57%			-4,518	76,542	20 May 2026	Direct
Vincent J. Angotti	TLPH	Common Stock	Tax liability	-1.24%			-9,938	790,767	02 Apr 2026	Direct
Raffi Asadorian	TLPH	Common Stock	Tax liability	-2.77%			-2,444	85,879	02 Apr 2026	Direct
Shakil Aslam	TLPH	Common Stock	Tax liability	-2.55%			-2,118	81,060	02 Apr 2026	Direct
Badri N. Dasu	TLPH	Common Stock	Tax liability	-3.31%			-2,444	71,440	02 Apr 2026	Direct
Vincent J. Angotti	TLPH	Common Stock	Purchase	36.3%	$125,000	$0.5860	213,310	800,705	13 Mar 2026	Direct
Nantahala Capital Management, LLC	TLPH	Pre-Funded Warrants	Award	29.3%			4,266,211	18,822,267	13 Mar 2026	See Footnote
Vincent J. Angotti	TLPH	Common Stock	Tax liability	-1.63%			-9,559	577,395	14 Feb 2026	Direct
Badri N. Dasu	TLPH	Common Stock	Tax liability	-3.08%			-2,346	73,884	14 Feb 2026	Direct
Raffi Asadorian	TLPH	Common Stock	Tax liability	-3.21%			-2,933	88,323	14 Feb 2026	Direct
Vincent J. Angotti	TLPH	Common Stock	Purchase	21.9%	$85,587	$0.8123	105,364	586,954	12 Feb 2026	Direct
Vincent J. Angotti	TLPH	Stock Option (Right to Buy)	Award				594,000	594,000	12 Feb 2026	Direct
Shakil Aslam	TLPH	Common Stock	Purchase	72.6%	$28,430	$0.8123	35,000	83,178	12 Feb 2026	Direct
Shakil Aslam	TLPH	Stock Option (Right to Buy)	Award				205,000	205,000	12 Feb 2026	Direct
Badri N. Dasu	TLPH	Common Stock	Purchase	84.9%	$28,430	$0.8123	35,000	76,230	12 Feb 2026	Direct
Badri N. Dasu	TLPH	Stock Option (Right to Buy)	Award				200,000	200,000	12 Feb 2026	Direct
Raffi Asadorian	TLPH	Commom Stock	Purchase	97.3%	$36,554	$0.8123	45,000	91,256	12 Feb 2026	Direct
Raffi Asadorian	TLPH	Stock Option (Right to Buy)	Award				260,000	260,000	12 Feb 2026	Direct
Vincent J. Angotti	TLPH	Common Stock	Tax liability	-0.66%			-3,179	481,590	10 Feb 2026	Direct
Badri N. Dasu	TLPH	Common Stock	Tax liability	-1.86%			-781	41,230	10 Feb 2026	Direct
Raffi Asadorian	TLPH	Common Stock	Tax liability	-2.03%			-958	46,256	10 Feb 2026	Direct
Stephen J. Hoffman	TLPH	Common Stock	Award	92.9%			4,267	8,859	23 Oct 2025	Direct
Stephen J. Hoffman	TLPH	Stock Option (Right to Buy)	Award				25,600	25,600	23 Oct 2025	Direct
Mark A. Wan	TLPH	Common Stock	Award	92.9%			4,267	8,859	23 Oct 2025	Direct
Mark A. Wan	TLPH	Stock Option (Right to Buy)	Award				25,600	25,600	23 Oct 2025	Direct
Marina Bozilenko	TLPH	Common Stock	Award	89.3%			4,267	9,047	23 Oct 2025	Direct
Marina Bozilenko	TLPH	Stock Option (Right to Buy)	Award				25,600	25,600	23 Oct 2025	Direct
Jill Marie Broadfoot	TLPH	Common Stock	Award	99.7%			4,267	8,547	23 Oct 2025	Direct
Jill Marie Broadfoot	TLPH	Stock Option (Right to Buy)	Award				25,600	25,600	23 Oct 2025	Direct
Adrian Adams	TLPH	Common Stock	Award	32%			4,267	17,609	23 Oct 2025	Direct
Adrian Adams	TLPH	Stock Option (Right to Buy)	Award				25,600	25,600	23 Oct 2025	Direct
Abhinav Jain	TLPH	Common Stock	Award	140.1%			4,267	7,312	23 Oct 2025	Direct
Abhinav Jain	TLPH	Stock Option (Right to Buy)	Award				25,600	25,600	23 Oct 2025	Direct
Joseph Todisco	TLPH	Common Stock	Award				6,397	6,397	15 Oct 2025	Direct
Joseph Todisco	TLPH	Director Stock Option (right to buy)	Award				38,381	38,381	15 Oct 2025	Direct

* An asterisk sign (*) next to the price indicates that the price is likely invalid.