Operating Margin of Karyopharm Therapeutics Inc. from 31 Dec 2016 to 31 Dec 2025

Taxonomy & unit
ratio: %
Description
The operating margin measures the profit a company makes on a dollar of sales after accounting for the direct costs involved in earning those revenues.
Summary
Karyopharm Therapeutics Inc. quarterly and annual Operating Margin in % history and change rate from 31 Dec 2016 to 31 Dec 2025.
  • Karyopharm Therapeutics Inc. Operating Margin for the quarter ending 31 Dec 2025 was -62%, a 24% increase year-over-year.
  • Karyopharm Therapeutics Inc. annual Operating Margin for 2025 was -62%, a 24% increase from 2024.
  • Karyopharm Therapeutics Inc. annual Operating Margin for 2024 was -82%, a 7.3% increase from 2023.
  • Karyopharm Therapeutics Inc. annual Operating Margin for 2023 was -89%, a 2% increase from 2022.
Operating Margin, Quarterly (%)
Operating Margin, YoY Quarterly Change (%)
Operating Margin, Annual (%)
Operating Margin, YoY Annual Change (%)

Karyopharm Therapeutics Inc. Quarterly Operating Margin (%)

Period Value YoY Chg Change % Start Date End Date
Q4 2025 -62% +20% +24% 01 Oct 2025 31 Dec 2025
Q3 2025 -73% +12% +14% 01 Jul 2025 30 Sep 2025
Q2 2025 -84% +6% +6.6% 01 Apr 2025 30 Jun 2025
Q1 2025 -84% +11% +11% 01 Jan 2025 31 Mar 2025
Q4 2024 -82% +6.5% +7.3% 01 Oct 2024 31 Dec 2024
Q3 2024 -85% +1.2% +1.4% 01 Jul 2024 30 Sep 2024
Q2 2024 -90% -4.2% -4.8% 01 Apr 2024 30 Jun 2024
Q1 2024 -94% -0.73% -0.78% 01 Jan 2024 31 Mar 2024
Q4 2023 -89% +1.8% +2% 01 Oct 2023 31 Dec 2023
Q3 2023 -86% -62% -250% 01 Jul 2023 30 Sep 2023
Q2 2023 -86% -56% -190% 01 Apr 2023 30 Jun 2023
Q1 2023 -94% -59% -172% 01 Jan 2023 31 Mar 2023
Q4 2022 -91% -44% -93% 01 Oct 2022 31 Dec 2022
Q3 2022 -25% +129% +84% 01 Jul 2022 30 Sep 2022
Q2 2022 -30% +152% +84% 01 Apr 2022 30 Jun 2022
Q1 2022 -34% +122% +78% 01 Jan 2022 31 Mar 2022
Q4 2021 -47% +112% +71% 01 Oct 2021 31 Dec 2021
Q3 2021 -154% +42% +21% 01 Jul 2021 30 Sep 2021
Q2 2021 -181% +24% +12% 01 Apr 2021 30 Jun 2021
Q1 2021 -156% +135% +46% 01 Jan 2021 31 Mar 2021
Q4 2020 -159% +304% +66% 01 Oct 2020 31 Dec 2020
Q3 2020 -195% +689% +78% 01 Jul 2020 30 Sep 2020
Q2 2020 -205% +1907% +90% 01 Apr 2020 30 Jun 2020
Q1 2020 -292% +713% +71% 01 Jan 2020 31 Mar 2020
Q4 2019 -463% +130% +22% 01 Oct 2019 31 Dec 2019
Q3 2019 -885% 01 Jul 2019 30 Sep 2019
Q2 2019 -2113% 01 Apr 2019 30 Jun 2019
Q1 2019 -1005% 01 Jan 2019 31 Mar 2019
Q4 2018 -593% 01 Oct 2018 31 Dec 2018

Karyopharm Therapeutics Inc. Annual Operating Margin (%)

Period Value YoY Chg Change % Start Date End Date
2025 -62% +20% +24% 01 Jan 2025 31 Dec 2025
2024 -82% +6.5% +7.3% 01 Jan 2024 31 Dec 2024
2023 -89% +1.8% +2% 01 Jan 2023 31 Dec 2023
2022 -91% -44% -93% 01 Jan 2022 31 Dec 2022
2021 -47% +112% +71% 01 Jan 2021 31 Dec 2021
2020 -159% +304% +66% 01 Jan 2020 31 Dec 2020
2019 -463% +130% +22% 01 Jan 2019 31 Dec 2019
2018 -593% +7540% +93% 01 Jan 2018 31 Dec 2018
2017 -8133% +63771% +89% 01 Jan 2017 31 Dec 2017
2016 -71904% 01 Jan 2016 31 Dec 2016
* An asterisk sign (*) next to the value indicates that the value is likely invalid.