RTW INVESTMENTS, LP - 23 Feb 2026 SCHEDULE 13D/A Report for ORCHESTRA BIOMED HOLDINGS, INC. Common Stock, par value $0.0001 per share (OBIO)

Filing Manager: RTW INVESTMENTS, LP
Reporting Manager: RTW Investments, LP
Security: ORCHESTRA BIOMED HOLDINGS, INC. Common Stock, par value $0.0001 per share
Symbol: OBIO
Shares outstanding: 60,621,452 shares
Disclosed Ownership: 11,942,426 shares
Ownership: 20%
Form type: SCHEDULE 13D/A
Filing time: 25 Feb 2026, 16:28:40 UTC
Date of event: 23 Feb 2026
Previous filing: 06 Aug 2025
Next filing: 29 Apr 2026
SEC: View on sec.gov

Key filing fact

RTW INVESTMENTS, LP disclosed 20% ownership in ORCHESTRA BIOMED HOLDINGS, INC. Common Stock, par value $0.0001 per share (OBIO) on 23 Feb 2026.

Key facts

RTW INVESTMENTS, LP filed SCHEDULE 13D/A for ORCHESTRA BIOMED HOLDINGS, INC. Common Stock, par value $0.0001 per share (OBIO).
Disclosed ownership: 20%.
Date of event: 23 Feb 2026.

This page explains what this Schedule 13D/13G filing tells you before manager-level rows.
You can verify ownership claims directly against the original SEC filing.

Backed by Schedule 13D/13G

Beneficial ownership values are sourced from the original SEC Schedule 13D/13G filing.

Reporting persons

Names, ownership, voting power, signatures, titles, and CIKs as disclosed in this Schedule 13D/G filing.

Name	Ownership	Shares Owned	shared voting power	Signature	Title	CIK
RTW Investments, LP	20%	11,942,426	11,942,426	/s/ Roderick Wong, M.D.	Roderick Wong, M.D., Managing Partner	0001493215
RTW Master Fund, Ltd.	10%	5,820,930	5,820,930	/s/ Darshan Patel	Darshan Patel, Director	0001493219
RTW Innovation Master Fund, Ltd.	8.4%	4,931,727	4,931,727	/s/ Darshan Patel	Darshan Patel, Director	0001776733
Roderick Wong	20%	11,942,426	11,942,426	/s/ Roderick Wong, M.D.	Roderick Wong, M.D.	0001493280

CIK / CUSIP context first

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